Azilsartan as a novel anti-ferriptotic agent via the upregulation of the Nrf2/HO-1/SLC7A11/GPX4 axis and downregulation of inflammatory pathways in folic acid-induced acute kidney injury in male mice
阿齐沙坦作为一种新型抗铁死亡药物,可通过上调 Nrf2/HO-1/SLC7A11/GPX4 轴和下调炎症通路,在叶酸诱导的雄性小鼠急性肾损伤中发挥作用。
期刊:Toxicology Reports
影响因子:
doi:10.1016/j.toxrep.2026.102204
Shihab, Elaf Mahmood; Abbas, Saba Naseer; Shareef, Saja Majeed; Hasan, Rana Jawad; Alsaraf, Khulood Majid; Fawzi, Hayder Adnan
炎症
炎症/感染
信号转导
铁死亡
GPX4
肾损伤
毒理研究