日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Quantitative high-throughput screening identifies small-molecule modulators of Wnt/β-catenin signaling

定量高通量筛选鉴定Wnt/β-catenin信号通路的小分子调节剂

期刊:Frontiers in Pharmacology
影响因子:4.8
doi:10.3389/fphar.2026.1788041
Chen, Xing; Yang, Shu; Sakamuru, Srilatha; Sukhawanit, Chainarong; Wood, Savannah; Ooka, Masato; Huang, Ruili; Xia, Menghang
信号转导
Wnt/β-Catenin
发表日期：2026
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Profiling of Environmental Mixtures Containing Metals for Their Toxicity Pathways and Mechanism of Action

对含金属环境混合物的毒性途径和作用机制进行分析

期刊:Environmental Science & Technology
影响因子:11.3
doi:10.1021/acs.est.4c07995
Ooka, Masato; Zhao, Jinghua; Zhang, Li; Huang, Ruili; Sakamuru, Srilatha; TeKrony, Charlotte; Hsieh, Jui-Hua; Collins, Bradley J; Dunnick, June K; Dixon, Darlene; Xia, Menghang
毒理研究
发表日期：2025
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Expanded Tox21 biological assay panel for the prediction of drug-induced liver injury and cardiotoxicity

用于预测药物性肝损伤和心脏毒性的扩展型 Tox21 生物检测组合

期刊:Environmental Health Perspectives
影响因子:9.8
doi:10.1289/EHP16190
Xu, Tuan; Ooka, Masato; Zhao, Jinghua; Sakamuru, Srilatha; Ngan, Deborah K; Zhang, Li; Yang, Shu; Travers, Jameson; Xia, Menghang; Zhao, Tongan; Klumpp-Thomas, Carleen; Zhu, Hu; Hall, Mathew D; Ferguson, Stephen; Shaw, Natalie D; Reif, David M; Simeonov, Anton; Huang, Ruili
肝损伤
毒理研究
发表日期：2025
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Lessons learned from evaluating defined chemical mixtures in a high-throughput estrogen receptor assay system

从高通量雌激素受体检测系统中评估特定化学混合物所汲取的经验教训

期刊:Toxicological Sciences
影响因子:4.1
doi:10.1093/toxsci/kfaf020
Parham, Fred; Eccles, Kristin M; Rider, Cynthia V; Sakamuru, Srilatha; Xia, Menghang; Huang, Ruili; Tice, Raymond R; Dinse, Gregg E; DeVito, Michael J
信号转导
免疫/内分泌
发表日期：2025
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Application of cytochrome P450 enzyme assays to predict p53 inducers and AChE inhibitors that require metabolic activation

应用细胞色素P450酶活性测定预测需要代谢活化的p53诱导剂和AChE抑制剂

期刊:Toxicology and Applied Pharmacology
影响因子:3.4
doi:10.1016/j.taap.2025.117315
Ngan, Deborah K; Sakamuru, Srilatha; Zhao, Jinghua; Xia, Menghang; Ferguson, Stephen S; Reif, David M; Simeonov, Anton; Huang, Ruili
细胞生物学
代谢
发表日期：2025
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Systematic evaluation of Tox21 compounds that target β-adrenergic receptors and their role in cardiotoxicity

对靶向β-肾上腺素能受体的Tox21化合物及其在心脏毒性中的作用进行系统评价

期刊:Toxicology and Applied Pharmacology
影响因子:3.4
doi:10.1016/j.taap.2025.117567
Luo, Xi; Zhang, Li; Sakamuru, Srilatha; Adesina, Precious A; Zhao, Jinghua; Xia, Menghang; Xu, Tuan; Ngan, Deborah K; Travers, Jameson; Wood, Savannah; Sukhawanit, Ray; Garrison, Anthony; Klumpp-Thomas, Carleen; Ferguson, Stephen S; Zhu, Hu; Hall, Matthew D; Reif, David M; Huang, Ruili
信号转导
毒理研究
免疫/内分泌
发表日期：2025
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High-Throughput Screening to Advance In Vitro Toxicology: Accomplishments, Challenges, and Future Directions

高通量筛选在体外毒理学发展中的应用：成就、挑战与未来方向

期刊:Annual Review of Pharmacology and Toxicology
影响因子:13.1
doi:10.1146/annurev-pharmtox-112122-104310
Lynch, Caitlin; Sakamuru, Srilatha; Ooka, Masato; Huang, Ruili; Klumpp-Thomas, Carleen; Shinn, Paul; Gerhold, David; Rossoshek, Anna; Michael, Sam; Casey, Warren; Santillo, Michael F; Fitzpatrick, Suzanne; Thomas, Russell S; Simeonov, Anton; Xia, Menghang
发表日期：2024
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Use of Tox21 screening data to profile PFAS bioactivities on nuclear receptors, cellular stress pathways, and cytochrome p450 enzymes

利用 Tox21 筛选数据分析 PFAS 对核受体、细胞应激通路和细胞色素 P450 酶的生物活性

期刊:Journal of Hazardous materials
影响因子:11.3
doi:10.1016/j.jhazmat.2024.134642
Ooka, Masato; Sakamuru, Srilatha; Zhao, Jinghua; Qu, Yanyan; Fang, Yuhong; Tao, Dingyin; Huang, Ruili; Ferguson, Stephen; Reif, David; Simeonov, Anton; Xia, Menghang
信号转导
细胞生物学
FAS
发表日期：2024
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Identification of human pregnane X receptor antagonists utilizing a high-throughput screening platform

利用高通量筛选平台鉴定人孕烷X受体拮抗剂

期刊:Frontiers in Pharmacology
影响因子:4.8
doi:10.3389/fphar.2024.1448744
Lynch, Caitlin; Margolis, Ryan; Niebler, Jacob; Travers, Jameson; Sakamuru, Srilatha; Zhao, Tongan; Klumpp-Thomas, Carleen; Huang, Ruili; Xia, Menghang
信号转导
发表日期：2024
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Identification of Environmental Compounds That May Trigger Early Female Puberty by Activating Human GnRHR and KISS1R

鉴定可能通过激活人类 GnRHR 和 KISS1R 引发女性青春期提前的环境化合物

期刊:Endocrinology
影响因子:3.8
doi:10.1210/endocr/bqae103
Shu Yang, Li Zhang, Kamal Khan, Jameson Travers, Ruili Huang, Vukasin M Jovanovic, Rithvik Veeramachaneni, Srilatha Sakamuru, Carlos A Tristan, Erica E Davis, Carleen Klumpp-Thomas, Kristine L Witt, Anton Simeonov, Natalie D Shaw, Menghang Xia
信号转导
Human
发表日期：2024
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