日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Discovery of Lenacapavir: First-in-Class Twice-Yearly Capsid Inhibitor for HIV-1 Treatment and Pre-exposure Prophylaxis

发现莱那卡帕韦:首个用于 HIV-1 治疗和暴露前预防的每年两次给药的衣壳抑制剂

Canales, Eda; Tse, Winston; Schroeder, Scott D; Chou, Chien-Hung; Liu, Qi; Zhang, Jennifer; Lazerwith, Scott E; Morganelli, Philip; Saito, Roland D; Brizgys, Gediminas; Li, Jiayao; Wu, Qiaoyin; Graupe, Michael; Halcomb, Randall L; Desai, Manoj; Cannizzaro, Carina; Hu, Eric; Perry, Jason K; Villaseñor, Armando G; Somoza, John R; Ferrao, Ryan D; Swaminathan, S; Zheng, Jim; Lu, Bing; Mwangi, Judy; Wang, Kelly; Subramanian, Raju; Smith, Bill J; Rhodes, Gerry; Rowe, William; Sauer, Dorothea; Lad, Latesh; Papalia, Giuseppe A; Clancy, Sheila; Stepan, George J; Yu, Helen; Sakowicz, Roman; Shi, Bing; Carr, Gavin; Bam, Rujuta A; Tsai, Luong K; Singer, Eric; Hansen, Derek; Mulato, Andrew; Yant, Stephen R; Cihlar, Tomas; Link, John O

Biochemical characterization of recombinant influenza A polymerase heterotrimer complex: Polymerase activity and mechanisms of action of nucleotide analogs

重组甲型流感病毒聚合酶异源三聚体复合物的生化特性:聚合酶活性和核苷酸类似物的作用机制

Barauskas, Ona; Xing, Weimei; Aguayo, Esmeralda; Willkom, Madeleine; Sapre, Annapurna; Clarke, Michael; Birkus, Gabriel; Schultz, Brian E; Sakowicz, Roman; Kwon, HyockJoo; Feng, Joy Y

Biochemical characterization of recombinant influenza A polymerase heterotrimer complex: Endonuclease activity and evaluation of inhibitors.

重组甲型流感聚合酶异三聚体复合物的生化特性:核酸内切酶活性及抑制剂评价

Xing Weimei, Barauskas Ona, Kirschberg Thorsten, Niedziela-Majka Anita, Clarke Michael, Birkus Gabriel, Weissburg Perry, Liu Xiaohong, Schultz Brian E, Sakowicz Roman, Kwon HyockJoo, Feng Joy Y

GS-5806 inhibits pre- to postfusion conformational changes of the respiratory syncytial virus fusion protein

GS-5806抑制呼吸道合胞病毒融合蛋白从融合前到融合后的构象变化

Samuel, Dharmaraj; Xing, Weimei; Niedziela-Majka, Anita; Wong, Jinny S; Hung, Magdeleine; Brendza, Katherine M; Perron, Michel; Jordan, Robert; Sperandio, David; Liu, Xiaohong; Mackman, Richard; Sakowicz, Roman

Structural and regulatory elements of HCV NS5B polymerase--β-loop and C-terminal tail--are required for activity of allosteric thumb site II inhibitors

HCV NS5B聚合酶的结构和调控元件——β环和C端尾部——是变构拇指位点II抑制剂发挥活性所必需的。

Boyce, Sarah E; Tirunagari, Neeraj; Niedziela-Majka, Anita; Perry, Jason; Wong, Melanie; Kan, Elaine; Lagpacan, Leanna; Barauskas, Ona; Hung, Magdeleine; Fenaux, Martijn; Appleby, Todd; Watkins, William J; Schmitz, Uli; Sakowicz, Roman

Cardiac myosin activation: a potential therapeutic approach for systolic heart failure

心肌肌球蛋白激活:一种治疗收缩性心力衰竭的潜在方法

Malik, Fady I; Hartman, James J; Elias, Kathleen A; Morgan, Bradley P; Rodriguez, Hector; Brejc, Katjusa; Anderson, Robert L; Sueoka, Sandra H; Lee, Kenneth H; Finer, Jeffrey T; Sakowicz, Roman; Baliga, Ramesh; Cox, David R; Garard, Marc; Godinez, Guillermo; Kawas, Raja; Kraynack, Erica; Lenzi, David; Lu, Pu Ping; Muci, Alexander; Niu, Congrong; Qian, Xiangping; Pierce, Daniel W; Pokrovskii, Maria; Suehiro, Ion; Sylvester, Sheila; Tochimoto, Todd; Valdez, Corey; Wang, Wenyue; Katori, Tatsuo; Kass, David A; Shen, You-Tang; Vatner, Stephen F; Morgans, David J

Insight into the molecular mechanism of the multitasking kinesin-8 motor.

深入了解多功能驱动蛋白-8马达的分子机制

Peters Carsten, Brejc Katjuša, Belmont Lisa, Bodey Andrew J, Lee Yan, Yu Ming, Guo Jun, Sakowicz Roman, Hartman James, Moores Carolyn A

The macroscopic rate of nucleic acid translocation by hepatitis C virus helicase NS3h is dependent on both sugar and base moieties

丙型肝炎病毒解旋酶NS3h介导的核酸转位宏观速率取决于糖基和碱基部分。

Khaki, Ali R; Field, Cassandra; Malik, Shuja; Niedziela-Majka, Anita; Leavitt, Stephanie A; Wang, Ruth; Hung, Magdeleine; Sakowicz, Roman; Brendza, Katherine M; Fischer, Christopher J