日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Discovery of IID432 for Chagas Disease: A Cyanotriazole Inhibitor of Trypanosoma cruzi Topoisomerase II Achieves Sterile Cure After Short-Term Treatment in a Chronic Infection Model

发现用于治疗恰加斯病的药物 IID432:一种氰基三唑类锥虫拓扑异构酶 II 抑制剂,在慢性感染模型中短期治疗后可实现完全治愈

René, Olivier; Saldivia, Manuel; Dauphinais, Maxime; Zhang, Lei; Hollingsworth, Scott A; Jiricek, Jan; Koester, Dennis C; Miller, Sarah L; Williams, Sarah L; Ng, Pearly S; Patra, Debjani; Jumani, Rajiv S; Baxley, Grace M; Osborne, Colin S; Chen, Ying-Bo; Chen, Yen-Liang; Cheung, Harry; Lakshminarayana, Suresh B; Galarneau, Jean-René; Diagana, Thierry T; Sarko, Christopher; Rao, Srinivasa P S

HaloPROTAC3 does not trigger the degradation of the halotagged parasitophorous vacuole membrane protein UIS4 during Plasmodium liver stage development.

HaloPROTAC3 在疟原虫肝期发育过程中不会引发带有 halotagged 标记的寄生虫空泡膜蛋白 UIS4 的降解

Lam Melanie, Probst Alexandra, Torres Laura, Lantigua Ashley A, Fishbaugher Matthew E, Kumar Jyothsna R, Saldivia Manuel, Torres Allison, Hegde Shreeya, Aleshnick Maya, Jennison Charlie, Roberson Sarah G H, Joyner Chester J, Vaughan Ashley M, Wilder Brandon K, Manneville Carole, Flannery Erika L, Marcellin David, Nyfeler Beat, Thiel Zacharias, Mikolajczak Sebastian A, Harupa Anke, Mitchell Gabriel

Third target of rapamycin complex negatively regulates development of quiescence in Trypanosoma brucei

雷帕霉素第三靶点复合物负调控布氏锥虫静止期的发育

Barquilla, Antonio; Saldivia, Manuel; Diaz, Rosario; Bart, Jean-Mathieu; Vidal, Isabel; Calvo, Enrique; Hall, Michael N; Navarro, Miguel