日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Small Molecule Kinase Inhibitors with In Vitro β-Hematin Formation and Plasmodium falciparum Protein Kinase G Inhibitory Activity Identified Using Machine Learning

利用机器学习鉴定出具有体外β-血红素形成活性和恶性疟原虫蛋白激酶G抑制活性的小分子激酶抑制剂

期刊:ChemMedChem
影响因子:3.4
doi:10.1002/cmdc.202500756
Thibaud, Jessica L; Salomane, Nicolaas; Harries, Sarah; Wicht, Kathryn J; Coulson, Lauren B; Kuter, David; Chibale, Kelly; de Villiers, Katherine A
信号转导
发表日期：2026
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Targeting Aurora Kinases as Essential Cell-Cycle Regulators to Deliver Multi-Stage Antimalarials Against Plasmodium Falciparum

以 Aurora 激酶为关键细胞周期调节因子，开发针对恶性疟原虫的多阶段抗疟药物

期刊:Angewandte Chemie-International Edition
影响因子:16.9
doi:10.1002/anie.202518493
Langeveld, Henrico; Maepa, Keletso; Maree, Marché; Thibaud, Jessica L; Salomane, Nicolaas; Bridgwater, Rosie; Famodimu, Mufuliat T; Godoy, Luiz C; Pasaje, Charisse Flerida A; Boonyalai, Nonlawat; de Souza, Mariana Laureano; Fong, Justin; Rabie, Tayla; van der Watt, Mariëtte; Theart, Rensu P; Ghidelli-Disse, Sonja; Niles, Jacquin C; Lee, Marcus C S; Winzeler, Elizabeth A; Delves, Michael J; Chibale, Kelly; Wicht, Kathryn J; Coulson, Lauren B; Birkholtz, Lyn-Marié
信号转导
细胞生物学
发表日期：2025
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Medicinal Chemistry Progression of Sapanisertib, the Anticancer and Dual Plasmodium Phosphatidylinositol 4-Kinase Beta and cGMP-Dependent Protein Kinase Inhibitor, for Malaria

Sapanisertib（一种抗癌药物和双重疟原虫磷脂酰肌醇 4-激酶 β 和 cGMP 依赖性蛋白激酶抑制剂，用于治疗疟疾）的药物化学进展

期刊:Journal of Medicinal Chemistry
影响因子:6.8
doi:10.1021/acs.jmedchem.4c02799
Gachuhi, Samuel; Kamunya, Stephanie; Fienberg, Stephen; Wambua, Lynn; Salomane, Nicolaas; Mayoka, Godfrey; Taylor, Dale; Coertzen, Dina; van der Watt, Mariette; Reader, Janette; Birkholtz, Lyn-Marié; Wittlin, Sergio; Krugmann, Liezl; Coulson, Lauren B; Chibale, Kelly
肿瘤
疟疾
肿瘤免疫
信号转导
微生物学
发表日期：2025
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Optimization of 2,8-Diaryl-1,5-naphthyridines as Plasmodium falciparum Phosphatidylinositol 4-Kinase Inhibitors with Improved ADME Profiles and In Vivo Efficacy

优化 2,8-二芳基-1,5-萘啶类化合物作为恶性疟原虫磷脂酰肌醇 4-激酶抑制剂，以改善其 ADME 特性和体内疗效

期刊:Journal of Medicinal Chemistry
影响因子:6.8
doi:10.1021/acs.jmedchem.5c02248
Dziwornu, Godwin A; Seanego, Donald; Fienberg, Stephen; Sypu, Venkata S; Salomane, Nicolaas; Krugmann, Liezl; Taylor, Dale; Masike, Keabetswe; Njoroge, Mathew; Boonyalai, Nonlawat; Lee, Marcus C S; Godoy, Luiz C; Pasaje, Charisse Flerida; Niles, Jacquin C; Basarab, Gregory S; Coulson, Lauren B; Ghorpade, Sandeep R; Chibale, Kelly
信号转导
发表日期：2025
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The impact of Iso-mukaadial acetate on Plasmodium falciparum transcriptional gene regulation

异粘菌素乙酸酯对恶性疟原虫转录基因调控的影响

期刊:Scientific Reports
影响因子:3.9
doi:10.1038/s41598-025-26347-9
Salomane, Nicolaas; Mafuna, Thendo; Allie, Farhahna; Mahlangu, Jabu Sam; van Zyl, Robyn Lyenne; Pooe, Ofentse; Simelane, Mthokozisi
信号转导
发表日期：2025
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2,8-Disubstituted-1,5-naphthyridines as Dual Inhibitors of Plasmodium falciparum Phosphatidylinositol-4-kinase and Hemozoin Formation with In Vivo Efficacy

2,8-二取代-1,5-萘啶作为恶性疟原虫磷脂酰肌醇-4-激酶和疟色素形成的双重抑制剂，具有体内功效

期刊:Journal of Medicinal Chemistry
影响因子:6.8
doi:10.1021/acs.jmedchem.4c01154
Godwin Akpeko Dziwornu, Donald Seanego, Stephen Fienberg, Monica Clements, Jasmin Ferreira, Venkata S Sypu, Sauvik Samanta, Ashlyn D Bhana, Constance M Korkor, Larnelle F Garnie, Nicole Teixeira, Kathryn J Wicht, Dale Taylor, Ronald Olckers, Mathew Njoroge, Liezl Gibhard, Nicolaas Salomane, Sergio W
信号转导
发表日期：2024
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Iso-mukaadial acetate and ursolic acid acetate inhibit the chaperone activity of Plasmodium falciparum heat shock protein 70-1

异木果酸乙酸酯和熊果酸乙酸酯抑制恶性疟原虫热休克蛋白70-1的伴侣活性

期刊:Cell Stress & Chaperones
影响因子:3.3
doi:10.1007/s12192-021-01212-6
Nicolaas Salomane, Ofentse J Pooe, Mthokozisi B C Simelane
发表日期：2021
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