日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Precision modeling of tumor antigen-specific T-cell responses in humanized mice for preclinical assessment of cancer immunotherapies

利用人源化小鼠进行肿瘤抗原特异性T细胞反应的精确建模,用于癌症免疫疗法的临床前评估

Gebhardt, Samuel; Le Clech, Marine; Höllbacher, Barbara; Brunner, Sarah; Varol, Ahmet; Lang, Simone; Jenni, Silvia; Briner, Stefanie; Yángüez, Emilio; Hüsser, Tamara; Domocos, Ioana; Tauscher, Ria; Eckmann, Jan; Münz, Christian; Sam, Johannes

Pathological insights of human CD34+ hematopoietic stem cell-engrafted NSG mice: Implications for the safety assessment of cancer immunotherapy drugs

人CD34+造血干细胞移植NSG小鼠的病理学见解:对癌症免疫治疗药物安全性评估的启示

Giusti, Anna Maria; Sam, Johannes; Colombetti, Sara; Veiga, Inês Berenguer; Monné Rodríguez, Josep M

Preclinical advances in glofitamab combinations: a new frontier for non-Hodgkin lymphoma

glofitamab联合疗法的临床前进展:非霍奇金淋巴瘤治疗的新前沿

Sam, Johannes; Leclercq-Cohen, Gabrielle; Gebhardt, Samuel; Surowka, Marlena; Herter, Sylvia; Lechner, Katharina; Relf, James; Briner, Stefanie; Varol, Ahmet; Appelt, Birte; Domocos, Ioana; Nicolini, Valeria; Bez, Miriam; Bommer, Esther; Jenni, Silvia; Schoenle, Anne; Le Clech, Marine; Colombetti, Sara; Klein, Christian; Umaña, Pablo; Lundberg, Pontus; Korfi, Koorosh; Bottos, Alessia; Bacac, Marina

Humanization of CD47 enables development of functional human neutrophils via postirradiation remodeling of the bone marrow

CD47 的人源化可通过骨髓照射后重塑促进功能性人中性粒细胞的发育。

Sefik, Esen; Philbrick, William; Zhang, Fengrui; Agrawal, Kriti; Van Lee, Brian; Sam, Johannes; Karatepe, Kutay; Zheng, Yunjiang; Liang, Kaixin; Peng, Sophia; Mirza, Haris; Rangavajhula, Athreya; Simon, Perrine; Arun, Neha; Babu, Priyanka; Eynon, Elizabeth; Chiorazzi, Michael; Shan, Liang; Halene, Stephanie; Luo, Hongbo R; Rongvaux, Anthony; Kluger, Yuval; Flavell, Richard A

Optimizing efficacy and safety of T cell bispecific antibodies: the interdependence of CD3 and tumor antigen binder affinities in FOLR1 and CEACAM5 2 + 1 TCBs

优化T细胞双特异性抗体的疗效和安全性:FOLR1和CEACAM5 2+1 TCB中CD3和肿瘤抗原结合亲和力的相互依赖性

Abdelmotaleb, Omar; Schneider, Anneliese; Waldhauer, Inja; Sam, Johannes; Hofer, Thomas; Lechmann, Martin; Freimoser-Grundschober, Anne; Giusti, Anna Maria; Essig, Katharina; Nikic, Tijana; Steinacher, Linda; Gassner, Christian; Märsch, Stephan; Bransi, Ali; Odermatt, Alex; Brünker, Peter; Colombetti, Sara; Klein, Christian

Chronic antigen stimulation in melanoma induces T cell exhaustion and limits efficacy of T cell bispecific therapies.

黑色素瘤中的慢性抗原刺激会导致 T 细胞耗竭,并限制 T 细胞双特异性疗法的疗效

Hutter-Karakoc Idil, Varypataki Eleni Maria, Neelakandhan Aparna, Lang Simone, Kramar Vesna, Varol Ahmet, Simons Sasha, Richard Marine, Pincha Mudita, Venetz Dario, Sam Johannes, Joller Nicole, Münz Christian, Umana Pablo, Klein Christian, Amann Maria

CEA-4-1BBL: CEACAM5-Targeted 4-1BB Ligand Fusion Proteins for Cis Co-Stimulation with CEA-TCB.

CEA-4-1BBL:靶向 CEACAM5 的 4-1BB 配体融合蛋白,用于与 CEA-TCB 进行顺式共刺激。

Claus Christina, Ferrara-Koller Claudia, Sam Johannes, Lang Sabine, Albrecht Rosmarie, Buser Regula B, Bommer Esther, Sala Grégory La, Nicolini Valeria G, Colombetti Sara, Bacac Marina, Umaña Pablo, Klein Christian

Innovations, challenges, and minimal information for standardization of humanized mice

人源化小鼠标准化方面的创新、挑战和信息匮乏

Stripecke, Renata; Münz, Christian; Schuringa, Jan Jacob; Bissig, Karl-Dimiter; Soper, Brian; Meeham, Terrence; Yao, Li-Chin; Di Santo, James P; Brehm, Michael; Rodriguez, Estefania; Wege, Anja Kathrin; Bonnet, Dominique; Guionaud, Silvia; Howard, Kristina E; Kitchen, Scott; Klein, Florian; Saeb-Parsy, Kourosh; Sam, Johannes; Sharma, Amar Deep; Trumpp, Andreas; Trusolino, Livio; Bult, Carol; Shultz, Leonard

Tumor-targeted 4-1BB agonists for combination with T cell bispecific antibodies as off-the-shelf therapy

靶向肿瘤的4-1BB激动剂与T细胞双特异性抗体联合使用,作为现成疗法

Claus, Christina; Ferrara, Claudia; Xu, Wei; Sam, Johannes; Lang, Sabine; Uhlenbrock, Franziska; Albrecht, Rosmarie; Herter, Sylvia; Schlenker, Ramona; Hüsser, Tamara; Diggelmann, Sarah; Challier, John; Mössner, Ekkehard; Hosse, Ralf J; Hofer, Thomas; Brünker, Peter; Joseph, Catherine; Benz, Jörg; Ringler, Philippe; Stahlberg, Henning; Lauer, Matthias; Perro, Mario; Chen, Stanford; Küttel, Christine; Bhavani Mohan, Preethi L; Nicolini, Valeria; Birk, Martina Carola; Ongaro, Amandine; Prince, Christophe; Gianotti, Reto; Dugan, Gregory; Whitlow, Christopher T; Solingapuram Sai, Kiran Kumar; Caudell, David L; Burgos-Rodriguez, Armando G; Cline, J Mark; Hettich, Michael; Ceppi, Maurizio; Giusti, Anna Maria; Crameri, Flavio; Driessen, Wouter; Morcos, Peter N; Freimoser-Grundschober, Anne; Levitsky, Victor; Amann, Maria; Grau-Richards, Sandra; von Hirschheydt, Thomas; Tournaviti, Stella; Mølhøj, Michael; Fauti, Tanja; Heinzelmann-Schwarz, Viola; Teichgräber, Volker; Colombetti, Sara; Bacac, Marina; Zippelius, Alfred; Klein, Christian; Umaña, Pablo