日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Decoding non-coding SNPs: systems genomics modelling dissects the heterogeneity of IBD

解码非编码SNP:系统基因组学建模剖析IBD的异质性

Módos, Dezső; Thomas, John P; Brooks-Warburton, Johanne; Poletti, Martina; Bohar, Balazs; Liu, Yufan; Madgwick, Matthew; Csabai, Luca; Kang, Wen-Xin; Alexander-Dann, Benjamin; Zoufir, Azedine; Sudhakar, Padhmanand; Cozzetto, Domenico; Fazekas, David; Samarajiwa, Shamith; Carding, Simon R; Powell, Nicholas; Verstockt, Bram; Bender, Andreas; Korcsmaros, Tamas

Identification of candidate causal variants and target genes at 41 breast cancer risk loci through differential allelic expression analysis

通过差异等位基因表达分析鉴定41个乳腺癌风险位点的候选致病变异和靶基因

Xavier, Joana M; Magno, Ramiro; Russell, Roslin; de Almeida, Bernardo P; Jacinta-Fernandes, Ana; Besouro-Duarte, André; Dunning, Mark; Samarajiwa, Shamith; O'Reilly, Martin; Maia, António M; Rocha, Cátia L; Rosli, Nordiana; Ponder, Bruce A J; Maia, Ana-Teresa

Early detection and diagnosis of cancer with interpretable machine learning to uncover cancer-specific DNA methylation patterns

利用可解释的机器学习技术早期检测和诊断癌症,以揭示癌症特异性DNA甲基化模式

Newsham, Izzy; Sendera, Marcin; Jammula, Sri Ganesh; Samarajiwa, Shamith A

Accurate detection of benign and malignant renal tumor subtypes with MethylBoostER: An epigenetic marker-driven learning framework

利用 MethylBoostER 准确检测良性和恶性肾肿瘤亚型:一种基于表观遗传标记的学习框架

Rossi, Sabrina H; Newsham, Izzy; Pita, Sara; Brennan, Kevin; Park, Gahee; Smith, Christopher G; Lach, Radoslaw P; Mitchell, Thomas; Huang, Junfan; Babbage, Anne; Warren, Anne Y; Leppert, John T; Stewart, Grant D; Gevaert, Olivier; Massie, Charles E; Samarajiwa, Shamith A

Genome co-amplification upregulates a mitotic gene network activity that predicts outcome and response to mitotic protein inhibitors in breast cancer

基因组共扩增上调有丝分裂基因网络活性,该网络可预测乳腺癌的预后和对有丝分裂蛋白抑制剂的反应。

Hu, Zhi; Mao, Jian-Hua; Curtis, Christina; Huang, Ge; Gu, Shenda; Heiser, Laura; Lenburg, Marc E; Korkola, James E; Bayani, Nora; Samarajiwa, Shamith; Seoane, Jose A; Dane, Mark A; Esch, Amanda; Feiler, Heidi S; Wang, Nicholas J; Hardwicke, Mary Ann; Laquerre, Sylvie; Jackson, Jeff; W Wood, Kenneth; Weber, Barbara; Spellman, Paul T; Aparicio, Samuel; Wooster, Richard; Caldas, Carlos; Gray, Joe W

Spatial coupling of mTOR and autophagy augments secretory phenotypes

mTOR与自噬的空间耦合增强了分泌表型

Narita, Masako; Young, Andrew R J; Arakawa, Satoko; Samarajiwa, Shamith A; Nakashima, Takayuki; Yoshida, Sei; Hong, Sungki; Berry, Lorraine S; Reichelt, Stefanie; Ferreira, Manuela; Tavaré, Simon; Inoki, Ken; Shimizu, Shigeomi; Narita, Masashi

HIV infection of dendritic cells subverts the IFN induction pathway via IRF-1 and inhibits type 1 IFN production.

HIV 感染树突状细胞会通过 IRF-1 破坏 IFN 诱导途径,抑制 1 型 IFN 的产生

Harman Andrew N, Lai Joey, Turville Stuart, Samarajiwa Shamith, Gray Lachlan, Marsden Valerie, Mercier Sarah K, Jones Kate, Nasr Najla, Rustagi Arjun, Cumming Helen, Donaghy Heather, Mak Johnson, Gale Michael Jr, Churchill Melissa, Hertzog Paul, Cunningham Anthony L