Samarakoon Rohan相关文献与解析，生知库 | 链接生命科学的每一步

SERPINE1: Role in Cholangiocarcinoma Progression and a Therapeutic Target in the Desmoplastic Microenvironment

SERPINE1：在胆管癌进展中的作用以及促纤维增生微环境中的治疗靶点

Czekay, Ralf-Peter; Higgins, Craig E; Aydin, Hasan Basri; Samarakoon, Rohan; Subasi, Nusret Bekir; Higgins, Stephen P; Lee, Hwajeong; Higgins, Paul J

胆管癌

Emerging Role of Hippo-YAP (Yes-Associated Protein)/TAZ (Transcriptional Coactivator with PDZ-Binding Motif) Pathway Dysregulation in Renal Cell Carcinoma Progression

Hippo-YAP（Yes相关蛋白）/TAZ（具有PDZ结合基序的转录共激活因子）通路失调在肾细胞癌进展中的新兴作用

期刊:Cancers

影响因子:4.4

doi:10.3390/cancers16152758

Mondal, Varsha; Higgins, Paul J; Samarakoon, Rohan

Downstream Targets of VHL/HIF-α Signaling in Renal Clear Cell Carcinoma Progression: Mechanisms and Therapeutic Relevance

肾透明细胞癌进展中VHL/HIF-α信号通路下游靶点：机制及治疗意义

期刊:Cancers

影响因子:4.4

doi:10.3390/cancers15041316

Mazumder, Sonia; Higgins, Paul J; Samarakoon, Rohan

Mineralocorticoid Receptor-Associated Mechanisms in Diabetic Kidney Disease and Clinical Significance of Mineralocorticoid Receptor Antagonists

糖尿病肾病中盐皮质激素受体相关机制及盐皮质激素受体拮抗剂的临床意义

期刊:American Journal of Nephrology

影响因子:3.2

doi:10.1159/000528783

Mende, Christian W; Samarakoon, Rohan; Higgins, Paul J

Emerging role of tumor suppressor p53 in acute and chronic kidney diseases

肿瘤抑制因子p53在急性和慢性肾脏疾病中的新兴作用

期刊:Cellular and Molecular Life Sciences

影响因子:6.2

doi:10.1007/s00018-022-04505-w

Overstreet, Jessica M; Gifford, Cody C; Tang, Jiaqi; Higgins, Paul J; Samarakoon, Rohan

Potential renal stem/progenitor cells identified by in vivo lineage tracing

通过体内谱系追踪鉴定出潜在的肾脏干/祖细胞

期刊:

影响因子:

doi:10.1152/ajprenal.00326.2021

Zhang, Wenzheng; Gao, Chao; Tsilosani, Akaki; Samarakoon, Rohan; Plews, Robert; Higgins, Paul J

细胞生物学

发表日期：2022

文献求助收藏

Increased mitochondrial calcium uptake and concomitant mitochondrial activity by presenilin loss promotes mTORC1 signaling to drive neurodegeneration

早老素缺失导致线粒体钙摄取增加和线粒体活性增强，进而促进 mTORC1 信号通路，驱动神经退行性变。

期刊:Aging Cell

影响因子:7.1

doi:10.1111/acel.13472

Ryan, Kerry C; Ashkavand, Zahra; Sarasija, Shaarika; Laboy, Jocelyn T; Samarakoon, Rohan; Norman, Kenneth R

The Genomic Response to TGF-β1 Dictates Failed Repair and Progression of Fibrotic Disease in the Obstructed Kidney

基因组对TGF-β1的反应决定了梗阻肾脏中纤维化疾病的修复失败和进展

期刊:Frontiers in Cell and Developmental Biology

影响因子:4.3

doi:10.3389/fcell.2021.678524

Higgins, Craig E; Tang, Jiaqi; Higgins, Stephen P; Gifford, Cody C; Mian, Badar M; Jones, David M; Zhang, Wenzheng; Costello, Angelica; Conti, David J; Samarakoon, Rohan; Higgins, Paul J

TGF-β1-p53 cooperativity regulates a profibrotic genomic program in the kidney: molecular mechanisms and clinical implications

TGF-β1-p53协同作用调控肾脏促纤维化基因组程序：分子机制和临床意义

期刊:FASEB Journal

影响因子:4.2

doi:10.1096/fj.201900943R

Higgins, Craig E; Tang, Jiaqi; Mian, Badar M; Higgins, Stephen P; Gifford, Cody C; Conti, David J; Meldrum, Kirstan K; Samarakoon, Rohan; Higgins, Paul J

Involvement of c-Myc/WWP1/TRIM65 Axis in Renal Fibrosis.

c-Myc/WWP1/TRIM65轴参与肾纤维化。

SERPINE1: Role in Cholangiocarcinoma Progression and a Therapeutic Target in the Desmoplastic Microenvironment

SERPINE1：在胆管癌进展中的作用以及促纤维增生微环境中的治疗靶点

Emerging Role of Hippo-YAP (Yes-Associated Protein)/TAZ (Transcriptional Coactivator with PDZ-Binding Motif) Pathway Dysregulation in Renal Cell Carcinoma Progression

Hippo-YAP（Yes相关蛋白）/TAZ（具有PDZ结合基序的转录共激活因子）通路失调在肾细胞癌进展中的新兴作用

Downstream Targets of VHL/HIF-α Signaling in Renal Clear Cell Carcinoma Progression: Mechanisms and Therapeutic Relevance

肾透明细胞癌进展中VHL/HIF-α信号通路下游靶点：机制及治疗意义

Mineralocorticoid Receptor-Associated Mechanisms in Diabetic Kidney Disease and Clinical Significance of Mineralocorticoid Receptor Antagonists

糖尿病肾病中盐皮质激素受体相关机制及盐皮质激素受体拮抗剂的临床意义

Emerging role of tumor suppressor p53 in acute and chronic kidney diseases

肿瘤抑制因子p53在急性和慢性肾脏疾病中的新兴作用

Potential renal stem/progenitor cells identified by in vivo lineage tracing

通过体内谱系追踪鉴定出潜在的肾脏干/祖细胞

Increased mitochondrial calcium uptake and concomitant mitochondrial activity by presenilin loss promotes mTORC1 signaling to drive neurodegeneration

早老素缺失导致线粒体钙摄取增加和线粒体活性增强，进而促进 mTORC1 信号通路，驱动神经退行性变。

The Genomic Response to TGF-β1 Dictates Failed Repair and Progression of Fibrotic Disease in the Obstructed Kidney

基因组对TGF-β1的反应决定了梗阻肾脏中纤维化疾病的修复失败和进展

TGF-β1-p53 cooperativity regulates a profibrotic genomic program in the kidney: molecular mechanisms and clinical implications

TGF-β1-p53协同作用调控肾脏促纤维化基因组程序：分子机制和临床意义