日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Distinct immune cell infiltration patterns in pancreatic ductal adenocarcinoma (PDAC) exhibit divergent immune cell selection and immunosuppressive mechanisms

胰腺导管腺癌 (PDAC) 中不同的免疫细胞浸润模式表现出不同的免疫细胞选择和免疫抑制机制。

Shivan Sivakumar # ,Ashwin Jainarayanan # ,Edward Arbe-Barnes # ,Piyush Kumar Sharma # ,Maire Ni Leathlobhair # ,Sakina Amin # ,David J Reiss # ,Lara Heij ,Samarth Hegde ,Assaf Magen ,Felicia Tucci ,Bo Sun ,Shihong Wu ,Nithishwer Mouroug Anand ,Hubert Slawinski ,Santiago Revale ,Isar Nassiri ,Jonathon Webber ,Gerard D Hoeltzel ,Adam E Frampton ,Georg Wiltberger ,Ulf Neumann ,Philip Charlton ,Laura Spiers ,Tim Elliott ,Maria Wang ,Suzana Couto ,Thomas Lila ,Pallavur V Sivakumar ,Alexander V Ratushny ,Mark R Middleton ,Dimitra Peppa ,Benjamin Fairfax ,Miriam Merad ,Michael L Dustin ,Enas Abu-Shah ,Rachael Bashford-Rogers

An IL-4 signalling axis in bone marrow drives pro-tumorigenic myelopoiesis

骨髓中的IL-4信号通路驱动促肿瘤髓系造血

Nelson M LaMarche ,Samarth Hegde # ,Matthew D Park # ,Barbara B Maier ,Leanna Troncoso ,Jessica Le Berichel ,Pauline Hamon ,Meriem Belabed ,Raphaël Mattiuz ,Clotilde Hennequin ,Theodore Chin ,Amanda M Reid ,Iván Reyes-Torres ,Erika Nemeth ,Ruiyuan Zhang ,Oakley C Olson ,Deborah B Doroshow ,Nicholas C Rohs ,Jorge E Gomez ,Rajwanth Veluswamy ,Nicole Hall ,Nicholas Venturini ,Florent Ginhoux ,Zhaoyuan Liu ,Mark Buckup ,Igor Figueiredo ,Vladimir Roudko ,Kensuke Miyake ,Hajime Karasuyama ,Edgar Gonzalez-Kozlova ,Sacha Gnjatic ,Emmanuelle Passegué ,Seunghee Kim-Schulze ,Brian D Brown ,Fred R Hirsch ,Brian S Kim ,Thomas U Marron ,Miriam Merad

Myeloid progenitor dysregulation fuels immunosuppressive macrophages in tumors

髓系祖细胞失调促进肿瘤中的免疫抑制巨噬细胞

Samarth Hegde, Bruno Giotti, Brian Y Soong, Laszlo Halasz, Jessica Le Berichel, Assaf Magen, Benoit Kloeckner, Raphaël Mattiuz, Matthew D Park, Adam Marks, Meriem Belabed, Pauline Hamon, Theodore Chin, Leanna Troncoso, Juliana J Lee, Dughan Ahimovic, Michael Bale, Grace Chung, Darwin D'souza, Krista

Intratumoral dendritic cell-CD4+ T helper cell niches enable CD8+ T cell differentiation following PD-1 blockade in hepatocellular carcinoma

肝细胞癌中,肿瘤内树突状细胞-CD4+ T辅助细胞微环境可促进PD-1阻断后CD8+ T细胞的分化。

Assaf Magen #,Pauline Hamon #,Nathalie Fiaschi,Brian Y Soong,Matthew D Park,Raphaël Mattiuz,Etienne Humblin,Leanna Troncoso,Darwin D'souza,Travis Dawson,Joel Kim,Steven Hamel,Mark Buckup,Christie Chang,Alexandra Tabachnikova,Hara Schwartz,Nausicaa Malissen,Yonit Lavin,Alessandra Soares-Schanoski,Bruno Giotti,Samarth Hegde,Giorgio Ioannou,Edgar Gonzalez-Kozlova,Clotilde Hennequin,Jessica Le Berichel,Zhen Zhao,Stephen C Ward,Isabel Fiel,Baijun Kou,Michael Dobosz,Lianjie Li,Christina Adler,Min Ni,Yi Wei,Wei Wang,Gurinder S Atwal,Kunal Kundu,Kamil J Cygan,Alexander M Tsankov,Adeeb Rahman,Colles Price,Nicolas Fernandez,Jiang He,Namita T Gupta,Seunghee Kim-Schulze,Sacha Gnjatic,Ephraim Kenigsberg,Raquel P Deering,Myron Schwartz,Thomas U Marron #,Gavin Thurston #,Alice O Kamphorst #,Miriam Merad #

TREM2 macrophages drive NK cell paucity and dysfunction in lung cancer

TREM2 巨噬细胞导致肺癌中的 NK 细胞缺乏和功能障碍

Matthew D Park #, Ivan Reyes-Torres #, Jessica LeBerichel, Pauline Hamon, Nelson M LaMarche, Samarth Hegde, Meriem Belabed, Leanna Troncoso, John A Grout, Assaf Magen, Etienne Humblin, Achuth Nair, Martina Molgora, Jinchao Hou, Jenna H Newman, Adam M Farkas, Andrew M Leader, Travis Dawson, Darwin D'

Dendritic Cell Paucity Leads to Dysfunctional Immune Surveillance in Pancreatic Cancer

树突状细胞缺乏导致胰腺癌免疫监视功能障碍

Samarth Hegde ,Varintra E Krisnawan ,Brett H Herzog ,Chong Zuo ,Marcus A Breden ,Brett L Knolhoff ,Graham D Hogg ,Jack P Tang ,John M Baer ,Cedric Mpoy ,Kyung Bae Lee ,Katherine A Alexander ,Buck E Rogers ,Kenneth M Murphy ,William G Hawkins ,Ryan C Fields ,Carl J DeSelm ,Julie K Schwarz ,David G DeNardo

Development of resistance to FAK inhibition in pancreatic cancer is linked to stromal depletion

胰腺癌对 FAK 抑制的耐药性发展与基质耗竭有关

Hong Jiang #, Xiuting Liu #, Brett L Knolhoff, Samarth Hegde, Kyung Bae Lee, Hongmei Jiang, Ryan C Fields, Jonathan A Pachter, Kian-Huat Lim, David G DeNardo

Targeting focal adhesion kinase renders pancreatic cancers responsive to checkpoint immunotherapy

靶向粘着斑激酶使胰腺癌对检查点免疫疗法产生反应

Hong Jiang, Samarth Hegde, Brett L Knolhoff, Yu Zhu, John M Herndon, Melissa A Meyer, Timothy M Nywening, William G Hawkins, Irina M Shapiro, David T Weaver, Jonathan A Pachter, Andrea Wang-Gillam, David G DeNardo

Sterile Inflammation Enhances ECM Degradation in Integrin β1 KO Embryonic Skin

无菌性炎症增强整合素 β1 KO 胚胎皮肤中的 ECM 降解

Ambika S Kurbet, Samarth Hegde, Oindrila Bhattacharjee, Srujan Marepally, Praveen K Vemula, Srikala Raghavan