Low-density lipoprotein receptor-deficient hepatocytes differentiated from induced pluripotent stem cells allow familial hypercholesterolemia modeling, CRISPR/Cas-mediated genetic correction, and productive hepatitis C virus infection
由诱导性多能干细胞分化而来的低密度脂蛋白受体缺陷型肝细胞可用于家族性高胆固醇血症建模、CRISPR/Cas 介导的基因校正以及丙型肝炎病毒的有效感染
期刊:Stem Cell Research
影响因子:7.1
doi:10.1186/s13287-019-1342-6
Jérôme Caron, Véronique Pène, Laia Tolosa, Maxime Villaret, Eléanor Luce, Angélique Fourrier, Jean-Marie Heslan, Samir Saheb, Eric Bruckert, María José Gómez-Lechón, Tuan Huy Nguyen, Arielle R Rosenberg, Anne Weber, Anne Dubart-Kupperschmitt
代谢
信号转导
免疫
发育与干细胞
微生物学
肝炎
干细胞
FCM
IF
IHC-P
WB
FETA
