Genome-wide analysis of ivermectin response by Onchocerca volvulus reveals that genetic drift and soft selective sweeps contribute to loss of drug sensitivity
对盘尾丝虫伊维菌素反应的全基因组分析表明,遗传漂变和软选择性清除是导致药物敏感性丧失的原因。
期刊:PLoS Neglected Tropical Diseases
影响因子:3.4
doi:10.1371/journal.pntd.0005816
Doyle, Stephen R; Bourguinat, Catherine; Nana-Djeunga, Hugues C; Kengne-Ouafo, Jonas A; Pion, Sébastien D S; Bopda, Jean; Kamgno, Joseph; Wanji, Samuel; Che, Hua; Kuesel, Annette C; Walker, Martin; Basáñez, Maria-Gloria; Boakye, Daniel A; Osei-Atweneboana, Mike Y; Boussinesq, Michel; Prichard, Roger K; Grant, Warwick N