日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Bespoke library docking for 5-HT2A receptor agonists with antidepressant activity

针对具有抗抑郁活性的5-HT2A受体激动剂的定制化化合物库对接

Anat Levit Kaplan #,Danielle N Confair #,Kuglae Kim #,Ximena Barros-Álvarez #,Ramona M Rodriguiz,Ying Yang,Oh Sang Kweon,Tao Che,John D McCorvy,David N Kamber,James P Phelan,Luan Carvalho Martins,Vladimir M Pogorelov,Jeffrey F DiBerto,Samuel T Slocum,Xi-Ping Huang,Jain Manish Kumar,Michael J Robertson,Ouliana Panova,Alpay B Seven,Autumn Q Wetsel,William C Wetsel,John J Irwin,Georgios Skiniotis,Brian K Shoichet,Bryan L Roth,Jonathan A Ellman

Structure, function and pharmacology of human itch GPCRs

人类瘙痒 GPCR 的结构、功能和药理学

Can Cao #, Hye Jin Kang #, Isha Singh, He Chen, Chengwei Zhang, Wenlei Ye, Byron W Hayes, Jing Liu, Ryan H Gumpper, Brian J Bender, Samuel T Slocum, Brian E Krumm, Katherine Lansu, John D McCorvy, Wesley K Kroeze, Justin G English, Jeffrey F DiBerto, Reid H J Olsen, Xi-Ping Huang, Shicheng Zhang, Yo

Oxidative Metabolism as a Modulator of Kratom's Biological Actions

氧化代谢作为 Kratom 生物作用的调节剂

Soumen Chakraborty, Rajendra Uprety, Samuel T Slocum, Takeshi Irie, Valerie Le Rouzic, Xiaohai Li, Lisa L Wilson, Brittany Scouller, Amy F Alder, Andrew C Kruegel, Michael Ansonoff, Andras Varadi, Shainnel O Eans, Amanda Hunkele, Abdullah Allaoa, Sanjay Kalra, Jin Xu, Ying Xian Pan, John Pintar, Bro

Controlling opioid receptor functional selectivity by targeting distinct subpockets of the orthosteric site

通过靶向正位点的不同亚区来控制阿片受体功能选择性

Rajendra Uprety #, Tao Che #, Saheem A Zaidi #, Steven G Grinnell, Balázs R Varga, Abdelfattah Faouzi, Samuel T Slocum, Abdullah Allaoa, András Varadi, Melissa Nelson, Sarah M Bernhard, Elizaveta Kulko, Valerie Le Rouzic, Shainnel O Eans, Chloe A Simons, Amanda Hunkele, Joan Subrath, Ying Xian Pan, 

Deschloroclozapine, a potent and selective chemogenetic actuator enables rapid neuronal and behavioral modulations in mice and monkeys

去氯氯氮平是一种强效且选择性的化学遗传致动器,能够快速调节小鼠和猴子的神经元和行为

Yuji Nagai #, Naohisa Miyakawa #, Hiroyuki Takuwa, Yukiko Hori, Kei Oyama, Bin Ji, Manami Takahashi, Xi-Ping Huang, Samuel T Slocum, Jeffrey F DiBerto, Yan Xiong, Takuya Urushihata, Toshiyuki Hirabayashi, Atsushi Fujimoto, Koki Mimura, Justin G English, Jing Liu, Ken-Ichi Inoue, Katsushi Kumata, Chi

Structural basis of ligand recognition at the human MT1 melatonin receptor

人类 MT1 褪黑激素受体配体识别的结构基础

Benjamin Stauch #, Linda C Johansson #, John D McCorvy, Nilkanth Patel, Gye Won Han, Xi-Ping Huang, Cornelius Gati, Alexander Batyuk, Samuel T Slocum, Andrii Ishchenko, Wolfgang Brehm, Thomas A White, Nairie Michaelian, Caleb Madsen, Lan Zhu, Thomas D Grant, Jessica M Grandner, Anna Shiriaeva, Reid

XFEL structures of the human MT2 melatonin receptor reveal the basis of subtype selectivity

人类 MT2 褪黑激素受体的 XFEL 结构揭示了亚型选择性的基础

Linda C Johansson #, Benjamin Stauch #, John D McCorvy, Gye Won Han, Nilkanth Patel, Xi-Ping Huang, Alexander Batyuk, Cornelius Gati, Samuel T Slocum, Chufeng Li, Jessica M Grandner, Shuming Hao, Reid H J Olsen, Alexandra R Tribo, Sahba Zaare, Lan Zhu, Nadia A Zatsepin, Uwe Weierstall, Saïd Yous, Ra