日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Retraction for Atractylenolide I enhances responsiveness to immune checkpoint blockade therapy by activating tumor antigen presentation

撤回研究表明，白术内酯I通过激活肿瘤抗原呈递增强对免疫检查点阻断疗法的反应。

期刊:Journal of Clinical Investigation
影响因子:13.6
doi:10.1172/JCI202473
Xu, Hanchen; Van der Jeught, Kevin; Zhou, Zhuolong; Zhang, Lu; Yu, Tao; Sun, Yifan; Li, Yujing; Wan, Changlin; So, Ka Man; Liu, Degang; Frieden, Michael; Fang, Yuanzhang; Mosley, Amber L; He, Xiaoming; Zhang, Xinna; Sandusky, George E; Liu, Yunlong; Meroueh, Samy O; Zhang, Chi; Wijeratne, Aruna B; Huang, Cheng; Ji, Guang; Lu, Xiongbin
肿瘤
肿瘤免疫
免疫/内分泌
发表日期：2026
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Degradation of the TEAD•YAP/TAZ Transcription Factor Complex by Heterobifunctional Small Molecules that Bind to the TEAD Allosteric Lipid Pocket.

异双功能小分子与 TEAD 变构脂质口袋结合，导致 TEAD•YAP/TAZ 转录因子复合物降解。

期刊:
影响因子:
doi:10.64898/2026.01.09.698724
Yeh I-Ju, Ghozayel Mona K, Bum-Erdene Khuchtumur, Meroueh Samy O
YAP
TAZ
发表日期：2026
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Small-Molecule KRAS Inhibitors by Tyrosine Covalent Bond Formation

通过酪氨酸共价键形成的小分子KRAS抑制剂

期刊:ChemMedChem
影响因子:3.6
doi:10.1002/cmdc.202400624.
Alexander D Landgraf ,Robert Brenner ,Mona K Ghozayel ,Khuchtumur Bum-Erdene ,Giovanni Gonzalez-Gutierrez ,Samy O Meroueh
信号转导
KRAS
发表日期：2025
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Exploring Covalent Bond Formation at Tyr-82 for Inhibition of Ral GTPase Activation

探索Tyr-82位点共价键形成对Ral GTPase活化的抑制作用

期刊:ChemMedChem
影响因子:3.6
doi:10.1002/cmdc.202300272
Alexander D Landgraf ,I-Ju Yeh ,Mona K Ghozayel ,Khuchtumur Bum-Erdene ,Giovanni Gonzalez-Gutierrez ,Samy O Meroueh
发表日期：2023
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Covalent Fragment Screening Identifies Rgl2 RalGEF Cysteine for Targeted Covalent Inhibition of Ral GTPase Activation

共价片段筛选鉴定出Rgl2 RalGEF半胱氨酸残基，用于靶向共价抑制Ral GTP酶的激活

期刊:ChemMedChem
影响因子:3.4
doi:10.1002/cmdc.202100750
Bum-Erdene, Khuchtumur; Ghozayel, Mona K; Xu, David; Meroueh, Samy O
发表日期：2022
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Atractylenolide I enhances responsiveness to immune checkpoint blockade therapy by activating tumor antigen presentation

阿特拉斯内酯I通过激活肿瘤抗原呈递增强对免疫检查点阻断疗法的反应性。

期刊:Journal of Clinical Investigation
影响因子:13.3
doi:10.1172/JCI146832
Hanchen Xu ，Kevin Van der Jeught ，Zhuolong Zhou ，Lu Zhang ，Tao Yu ，Yifan Sun ，Yujing Li ，Changlin Wan ，Ka Man So ，Degang Liu ，Michael Frieden ，Yuanzhang Fang ，Amber L Mosley ，Xiaoming He ，Xinna Zhang ，George E Sandusky ，Yunlong Liu ，Samy O Meroueh ，Chi Zhang ，Aruna B Wijeratne ，Cheng Huang ，Guang Ji ，Xiongbin Lu
免疫/内分泌
肿瘤免疫
肿瘤
发表日期：2021
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Small-molecule covalent bond formation at tyrosine creates a binding site and inhibits activation of Ral GTPases.

小分子共价键在酪氨酸处形成结合位点，抑制 Ral GTP 酶的活化

期刊:Proceedings of the National Academy of Sciences of the United States of America
影响因子:9.1
doi:10.1073/pnas.1913654117
Bum-Erdene Khuchtumur, Liu Degang, Gonzalez-Gutierrez Giovanni, Ghozayel Mona K, Xu David, Meroueh Samy O
信号转导
发表日期：2020
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Phenotypic Screening of Chemical Libraries Enriched by Molecular Docking to Multiple Targets Selected from Glioblastoma Genomic Data

通过分子对接富集的化学文库的表型筛选，筛选从胶质母细胞瘤基因组数据中选择的多个靶点

期刊:ACS Chemical Biology
影响因子:3.5
doi:10.1021/acschembio.0c00078
David Xu, Donghui Zhou, Khuchtumur Bum-Erdene, Barbara J Bailey, Kamakshi Sishtla, Sheng Liu, Jun Wan, Uma K Aryal, Jonathan A Lee, Clark D Wells, Melissa L Fishel, Timothy W Corson, Karen E Pollok, Samy O Meroueh
免疫
细胞生物学
胶质细胞
发表日期：2020
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Chemical Space Overlap with Critical Protein-Protein Interface Residues in Commercial and Specialized Small-Molecule Libraries

商业和专业小分子库中与关键蛋白质-蛋白质界面残基的化学空间重叠

期刊:ChemMedChem
影响因子:3.4
doi:10.1002/cmdc.201800537
Si, Yubing; Xu, David; Bum-Erdene, Khuchtumur; Ghozayel, Mona K; Yang, Baocheng; Clemons, Paul A; Meroueh, Samy O
发表日期：2019
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Small-molecule CaVα1⋅CaVβ antagonist suppresses neuronal voltage-gated calcium-channel trafficking

小分子 CaVα1⋅CaVβ 拮抗剂抑制神经元电压门控钙通道运输

期刊:Proceedings of the National Academy of Sciences of the United States of America
影响因子:
doi:10.1073/pnas.1813157115
Xingjuan Chen, Degang Liu, Donghui Zhou, Yubing Si, David Xu, Christopher W Stamatkin, Mona K Ghozayel, Matthew S Ripsch, Alexander G Obukhov, Fletcher A White, Samy O Meroueh
神经
发表日期：2018
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