日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

TLR9-independent CD8+ T cell responses in hepatic AAV gene transfer through IL-1R1-MyD88 signaling

通过 IL-1R1-MyD88 信号传导在肝脏 AAV 基因转移中实现 TLR9 独立的 CD8+ T 细胞应答

Sandeep R P Kumar, Moanaro Biswas, Di Cao, Sreevani Arisa, Maite Muñoz-Melero, Anh K Lam, Annie R Piñeros, Reuben Kapur, Tsuneyasu Kaisho, Randal J Kaufman, Weidong Xiao, Dmitry M Shayakhmetov, Cox Terhorst, Ype P de Jong, Roland W Herzog

B cell focused transient immune suppression protocol for efficient AAV readministration to the liver

以 B 细胞为重点的瞬时免疫抑制方案可有效将 AAV 重新注射至肝脏

Jyoti Rana, Roland W Herzog, Maite Muñoz-Melero, Kentaro Yamada, Sandeep R P Kumar, Anh K Lam, David M Markusic, Dongsheng Duan, Cox Terhorst, Barry J Byrne, Manuela Corti, Moanaro Biswas

IL-15 blockade and rapamycin rescue multifactorial loss of factor VIII from AAV-transduced hepatocytes in hemophilia A mice

IL-15 阻断和雷帕霉素可挽救血友病 A 小鼠中 AAV 转导肝细胞中因子 VIII 的多因素损失

John S S Butterfield, Kentaro Yamada, Thais B Bertolini, Farooq Syed, Sandeep R P Kumar, Xin Li, Sreevani Arisa, Annie R Piñeros, Alejandro Tapia, Christopher A Rogers, Ning Li, Jyoti Rana, Moanaro Biswas, Cox Terhorst, Randal J Kaufman, Ype P de Jong, Roland W Herzog

Cas9-specific immune responses compromise local and systemic AAV CRISPR therapy in multiple dystrophic canine models

Cas9 特异性免疫反应影响多种营养不良犬模型中的局部和全身 AAV CRISPR 疗法

Chady H Hakim, Sandeep R P Kumar #, Dennis O Pérez-López #, Nalinda B Wasala, Dong Zhang, Yongping Yue, James Teixeira, Xiufang Pan, Keqing Zhang, Emily D Million, Christopher E Nelson, Samantha Metzger, Jin Han, Jacqueline A Louderman, Florian Schmidt, Feng Feng, Dirk Grimm, Bruce F Smith, Gang Yao

CAR- and TRuC-redirected regulatory T cells differ in capacity to control adaptive immunity to FVIII

CAR 和 TRuC 重定向的调节性 T 细胞在控制 FVIII 适应性免疫的能力方面有所不同

Jyoti Rana, Daniel J Perry, Sandeep R P Kumar, Maite Muñoz-Melero, Rania Saboungi, Todd M Brusko, Moanaro Biswas

Coagulation factor IX gene transfer to non-human primates using engineered AAV3 capsid and hepatic optimized expression cassette

使用工程化的 AAV3 衣壳和肝脏优化表达盒将凝血因子 IX 基因转移到非人类灵长类动物

Sandeep R P Kumar, Jun Xie, Shilang Hu, Jihye Ko, Qifeng Huang, Harrison C Brown, Alok Srivastava, David M Markusic, Christopher B Doering, H Trent Spencer, Arun Srivastava, Guangping Gao, Roland W Herzog

Role of Small Intestine and Gut Microbiome in Plant-Based Oral Tolerance for Hemophilia

小肠和肠道微生物群在血友病植物性口服耐受中的作用

Sandeep R P Kumar, Xiaomei Wang, Nagavardhini Avuthu, Thais B Bertolini, Cox Terhorst, Chittibabu Guda, Henry Daniell, Roland W Herzog

B Cell Depletion Eliminates FVIII Memory B Cells and Enhances AAV8-coF8 Immune Tolerance Induction When Combined With Rapamycin

细胞耗竭消除 FVIII 记忆 B 细胞并与雷帕霉素联合使用可增强 AAV8-coF8 免疫耐受诱导

Moanaro Biswas, Brett Palaschak, Sandeep R P Kumar, Jyoti Rana, David M Markusic

PB1-F2 Protein Does Not Impact the Virulence of Triple-Reassortant H3N2 Swine Influenza Virus in Pigs but Alters Pathogenicity and Transmission in Turkeys

PB1-F2 蛋白不影响三重配 H3N2 猪流感病毒在猪中的毒力,但会改变其在火鸡中的致病性和传播

Jagadeeswaran Deventhiran, Sandeep R P Kumar, Shobana Raghunath, Tanya Leroith, Subbiah Elankumaran