日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Multiomics and machine-learning identify novel transcriptional and mutational signatures in amyotrophic lateral sclerosis

多组学和机器学习识别肌萎缩侧索硬化症中的新转录和突变特征

Alberto Catanese, Sandeep Rajkumar, Daniel Sommer, Pegah Masrori, Nicole Hersmus, Philip Van Damme, Simon Witzel, Albert Ludolph, Ritchie Ho, Tobias M Boeckers, Medhanie Mulaw

Integrative proteomics highlight presynaptic alterations and c-Jun misactivation as convergent pathomechanisms in ALS

整合蛋白质组学强调突触前改变和 c-Jun 失活是 ALS 中的收敛病理机制

Amr Aly #, Zsofia I Laszlo #, Sandeep Rajkumar, Tugba Demir, Nicole Hindley, Douglas J Lamont, Johannes Lehmann, Mira Seidel, Daniel Sommer, Mirita Franz-Wachtel, Francesca Barletta, Simon Heumos, Stefan Czemmel, Edor Kabashi, Albert Ludolph, Tobias M Boeckers, Christopher M Henstridge, Alberto Cata

Fast and efficient synaptosome isolation and post-synaptic density enrichment from hiPSC-motor neurons by biochemical sub-cellular fractionation

通过生化亚细胞分离从 hiPSC 运动神经元中快速有效地分离突触体并富集突触后密度

Sandeep Rajkumar, Tobias M Böckers, Alberto Catanese

Propranolol reduces the accumulation of cytotoxic aggregates in C9orf72-ALS/FTD in vitro models

普萘洛尔可减少 C9orf72-ALS/FTD 体外模型中细胞毒性聚集体的积累

Mira Seidel, Sandeep Rajkumar, Christina Steffke, Vivien Noeth, Shreya Agarwal, Kevin Roger, Joanna Lipecka, Albert Ludolph, Chiara Ida Guerrera, Tobias Boeckers, Alberto Catanese

Aging-Dependent Altered Transcriptional Programs Underlie Activity Impairments in Human C9orf72-Mutant Motor Neurons

衰老依赖性转录程序改变是人类 C9orf72 突变运动神经元活动受损的原因

Daniel Sommer, Sandeep Rajkumar, Mira Seidel, Amr Aly, Albert Ludolph, Ritchie Ho, Tobias M Boeckers, Alberto Catanese

Synaptic disruption and CREB-regulated transcription are restored by K+ channel blockers in ALS

在肌萎缩侧索硬化症(ALS)中,钾离子通道阻滞剂可以恢复突触功能紊乱和CREB调控的转录。

Alberto Catanese ,Sandeep Rajkumar ,Daniel Sommer ,Dennis Freisem ,Alexander Wirth ,Amr Aly ,David Massa-López ,Andrea Olivieri ,Federica Torelli ,Valentin Ioannidis ,Joanna Lipecka ,Ida Chiara Guerrera ,Daniel Zytnicki ,Albert Ludolph ,Edor Kabashi ,Medhanie A Mulaw ,Francesco Roselli ,Tobias M Böckers

GDF15 promotes simultaneous astrocyte remodeling and tight junction strengthening at the blood-brain barrier

GDF15 促进血脑屏障上的星形胶质细胞重塑和紧密连接强化

Victoria A Malik, Franziska Zajicek, Laura A Mittmann, Johannes Klaus, Sandra Unterseer, Sandeep Rajkumar, Benno Pütz, Jan M Deussing, Inga D Neumann, Rainer Rupprecht, Barbara Di Benedetto