日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Selective ubiquitination of drug-like small molecules by the ubiquitin ligase HUWE1.

泛素连接酶 HUWE1 对药物样小分子进行选择性泛素化

Orth Barbara, Pohl Pavel, Aust Florian, Ji Yanlong, Seenivasan Ayshwarya, Dybkov Olexandr, Liang Xiaojun Julia, Bock Lars, Leidner Florian, Levantovsky Sophie, Schardey Patrick, Sander Pascal, Disch Nathanael J, Trautz Masanja L, Mizi Athanasia, Papantonis Argyris, Lenz Christof, Grubmüller Helmut, Steinchen Wieland, Behrends Christian, Urlaub Henning, Gehringer Matthias, Lorenz Sonja

Discovery of the First Highly Selective 1,4-dihydropyrido[3,4-b]pyrazin-3(2H)-one MKK4 Inhibitor.

发现首个高选择性 1,4-二氢吡啶并[3,4-b]吡嗪-3(2H)-酮 MKK4 抑制剂

Katzengruber Leon, Sander Pascal, Zwirner Stefan, Rasch Alexander, Eberlein Eric, Selig Roland, Albrecht Wolfgang, Zender Lars, Laufer Stefan A

MKK4 Inhibitors-Recent Development Status and Therapeutic Potential

MKK4抑制剂——最新进展及治疗潜力

Katzengruber, Leon; Sander, Pascal; Laufer, Stefan