日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Biotransformation of the Novel Myeloperoxidase Inhibitor AZD4831 in Preclinical Species and Humans

新型髓过氧化物酶抑制剂AZD4831在临床前动物和人体内的生物转化

Jurva, Ulrik; Weidolf, Lars; Sandinge, Ann-Sofie; Leandersson, Carina; Ekdahl, Anja; Li, Xue-Qing; Antonsson, Thomas; Sundell, Johan; Westerlund, Kristina; Amilon, Carl; Inghardt, Tord; Gopaul, V Sashi

Ancestral Sequence Reconstruction of a Cytochrome P450 Family Involved in Chemical Defense Reveals the Functional Evolution of a Promiscuous, Xenobiotic-Metabolizing Enzyme in Vertebrates

参与化学防御的细胞色素P450家族的祖先序列重建揭示了脊椎动物中一种具有广泛底物特异性、能代谢外源物质的酶的功能进化

Harris, Kurt L; Thomson, Raine E S; Gumulya, Yosephine; Foley, Gabriel; Carrera-Pacheco, Saskya E; Syed, Parnayan; Janosik, Tomasz; Sandinge, Ann-Sofie; Andersson, Shalini; Jurva, Ulrik; Bodén, Mikael; Gillam, Elizabeth M J

Inhibition of SGLT2 Preserves Function and Promotes Proliferation of Human Islets Cells In Vivo in Diabetic Mice

抑制 SGLT2 可保留糖尿病小鼠体内人类胰岛细胞的功能并促进其增殖

Daniel Karlsson, Andrea Ahnmark, Alan Sabirsh, Anne-Christine Andréasson, Peter Gennemark, Ann-Sofie Sandinge, Lihua Chen, Björn Tyrberg, Daniel Lindén, Maria Sörhede Winzell

Functionalized lipid nanoparticles for subcutaneous administration of mRNA to achieve systemic exposures of a therapeutic protein

用于皮下注射mRNA以实现治疗性蛋白全身暴露的功能化脂质纳米颗粒

Davies, Nigel; Hovdal, Daniel; Edmunds, Nicholas; Nordberg, Peter; Dahlén, Anders; Dabkowska, Aleksandra; Arteta, Marianna Yanez; Radulescu, Aurel; Kjellman, Tomas; Höijer, Andreas; Seeliger, Frank; Holmedal, Elin; Andihn, Elisabeth; Bergenhem, Nils; Sandinge, Ann-Sofie; Johansson, Camilla; Hultin, Leif; Johansson, Marie; Lindqvist, Johnny; Björsson, Liselotte; Jing, Yujia; Bartesaghi, Stefano; Lindfors, Lennart; Andersson, Shalini

Quantification of unbound concentration of ticagrelor in plasma as a proof of mechanism biomarker of the reversal agent, MEDI2452

定量分析血浆中替格瑞洛的游离浓度,作为逆转剂 MEDI2452 作用机制的生物标志物证明

Ann-Sofie Sandinge, Annika Janefeldt, Susanne Pehrsson, Sven Nylander

Unraveling the pharmacokinetic interaction of ticagrelor and MEDI2452 (Ticagrelor antidote) by mathematical modeling

利用数学模型揭示替格瑞洛与MEDI2452(替格瑞洛解毒剂)的药代动力学相互作用

Almquist, J; Penney, M; Pehrsson, S; Sandinge, A-S; Janefeldt, A; Maqbool, S; Madalli, S; Goodman, J; Nylander, S; Gennemark, P