日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Autophagy is a novel pathway for neurofilament protein degradation in vivo

自噬是体内神经丝蛋白降解的一种新途径

Mala V Rao, Sandipkumar Darji, Philip H Stavrides, Chris N Goulbourne, Asok Kumar, Dun-Sheng Yang, Lang Yoo, James Peddy, Ju-Hyun Lee, Aidong Yuan, Ralph A Nixon

Lysosomal dysfunction in Down syndrome and Alzheimer mouse models is caused by v-ATPase inhibition by Tyr682-phosphorylated APP βCTF

唐氏综合征和阿尔茨海默氏症小鼠模型中的溶酶体功能障碍是由 Tyr682 磷酸化的 APP βCTF 抑制 v-ATPase 引起的

Eunju Im, Ying Jiang, Philip H Stavrides, Sandipkumar Darji, Hediye Erdjument-Bromage, Thomas A Neubert, Jun Yong Choi, Jerzy Wegiel, Ju-Hyun Lee, Ralph A Nixon

Preclinical and randomized clinical evaluation of the p38α kinase inhibitor neflamapimod for basal forebrain cholinergic degeneration

对 p38α 激酶抑制剂 neflamapimod 治疗基底前脑胆碱能变性的临床前和随机临床试验进行评估

Ying Jiang # ,John J Alam # ,Stephen N Gomperts ,Paul Maruff ,Afina W Lemstra ,Ursula A Germann ,Philip H Stavrides ,Sandipkumar Darji ,Sandeep Malampati ,James Peddy ,Cynthia Bleiwas ,Monika Pawlik ,Anna Pensalfini ,Dun-Sheng Yang ,Shivakumar Subbanna ,Balapal S Basavarajappa ,John F Smiley ,Amanda Gardner ,Kelly Blackburn ,Hui-May Chu ,Niels D Prins ,Charlotte E Teunissen ,John E Harrison ,Philip Scheltens ,Ralph A Nixon

Endosomal Dysfunction Induced by Directly Overactivating Rab5 Recapitulates Prodromal and Neurodegenerative Features of Alzheimer's Disease

直接过度激活 Rab5 引起的内体功能障碍重现了阿尔茨海默病的前驱症状和神经退行性特征

Anna Pensalfini, Seonil Kim, Shivakumar Subbanna, Cynthia Bleiwas, Chris N Goulbourne, Philip H Stavrides, Ying Jiang, Ju-Hyun Lee, Sandipkumar Darji, Monika Pawlik, Chunfeng Huo, James Peddy, Martin J Berg, John F Smiley, Balapal S Basavarajappa, Ralph A Nixon

β2-adrenergic Agonists Rescue Lysosome Acidification and Function in PSEN1 Deficiency by Reversing Defective ER-to-lysosome Delivery of ClC-7

β2-肾上腺素能激动剂通过逆转内质网到溶酶体的 ClC-7 传递缺陷来挽救 PSEN1 缺乏症中的溶酶体酸化和功能

Ju-Hyun Lee, Devin M Wolfe, Sandipkumar Darji, Mary Kate McBrayer, Daniel J Colacurcio, Asok Kumar, Philip Stavrides, Panaiyur S Mohan, Ralph A Nixon

mTOR hyperactivation in Down Syndrome underlies deficits in autophagy induction, autophagosome formation, and mitophagy

唐氏综合症中的 mTOR 过度激活是自噬诱导、自噬体形成和线粒体自噬缺陷的根本原因

Matteo Bordi, Sandipkumar Darji, Yutaka Sato, Marian Mellén, Martin J Berg, Asok Kumar, Ying Jiang, Ralph A Nixon

Lysosomal Dysfunction in Down Syndrome Is APP-Dependent and Mediated by APP-βCTF (C99)

唐氏综合症中的溶酶体功能障碍是 APP 依赖性的,并由 APP-βCTF (C99) 介导

Ying Jiang, Yutaka Sato, Eunju Im, Martin Berg, Matteo Bordi, Sandipkumar Darji, Asok Kumar, Panaiyur S Mohan, Urmi Bandyopadhyay, Antonio Diaz, Ana Maria Cuervo, Ralph A Nixon