Key mutations in the C-terminus of the HBV surface glycoprotein correlate with lower HBsAg levels in vivo, hinder HBsAg secretion in vitro and reduce HBsAg structural stability in the setting of HBeAg-negative chronic HBV genotype-D infection
乙型肝炎病毒表面糖蛋白C端关键突变与体内乙型肝炎表面抗原（HBsAg）水平降低相关，在体外抑制HBsAg分泌，并在HBeAg阴性慢性乙型肝炎病毒D基因型感染的情况下降低HBsAg的结构稳定性。
期刊:Emerging Microbes & Infections
影响因子:7.5
doi:10.1080/22221751.2020.1757998
Salpini, Romina; Battisti, Arianna; Piermatteo, Lorenzo; Carioti, Luca; Anastasiou, Olympia E; Gill, Upkar S; Di Carlo, Domenico; Colagrossi, Luna; Duca, Leonardo; Bertoli, Ada; La Rosa, Katia Yu; Fabeni, Lavinia; Iuvara, Alessandra; Malagnino, Vincenzo; Cerva, Carlotta; Lichtner, Miriam; Mastroianni, Claudio M; De Sanctis, Giuseppe Maria; Paoloni, Maurizio; Marignani, Massimo; Pasquazzi, Caterina; Iapadre, Nerio; Parruti, Giustino; Vecchiet, Jacopo; Sarmati, Loredana; Andreoni, Massimo; Angelico, Mario; Grelli, Sandro; T Kennedy, Patrick; Verheyen, Jens; Aquaro, Stefano; Silberstein, Francesca Ceccherini; Perno, Carlo Federico; Svicher, Valentina
