Farnesyltransferase inhibitor LB42708 disables oncogenic RAS signaling and overcomes gefitinib resistance in NSCLC via FTase α-subunit and RAS degradation.
法尼基转移酶抑制剂 LB42708 通过 FTase α 亚基和 RAS 降解来抑制致癌 RAS 信号传导，从而克服 NSCLC 中的吉非替尼耐药性。
期刊:Cell Communication and Signaling
影响因子:8.9
doi:10.1186/s12964-026-02798-z
Luo Guancong, Li Dexuan, Peng Jun, Liu Rongsheng, Meng Yajing, Ward Richard, Zhang Yangyang, Zhang Xinyu, Cui Fengxian, Wang Jiwei, Yang Xiuyu, Chen Mo, Xu Yanjun, Chen Sheng, Jiang Wenyu, Zhang Le, Li Yurong, Yang Yang, Xiang Cheng, Guo Xiaoxi, Dai Jiameng, Sang Jun, Xu Tian-Rui, An Su
