日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Hepatic zonation determines tumorigenic potential of mutant β-catenin.

肝脏分区决定突变β-catenin的致瘤潜力。

Raven Alexander, Gilroy Kathryn, Jin Hu, Waldron Joseph A, Leslie Holly, Munro June, Hall Holly, Ridgway Rachel A, Ford Catriona A, Gulhan Doga C, Vlahov Nikola, Mills Megan L, Hartley Andrew, Anderson Eve, Bryson Sheila, Sphyris Nathalie, Müller Miryam, May Stephanie, Cadden Barbara, Nixon Colin, Waddell Scott H, Guest Rachel, Boulter Luke, Barker Nick, Clevers Hans, Zhu Hao, Ivaska Johanna, Strathdee Douglas, Miller Crispin J, Jamieson Nigel B, Bushell Martin, Park Peter J, Bird Thomas G, Sansom Owen J

Nucleophosmin supports WNT-driven hyperproliferation and tumor initiation

核磷蛋白支持WNT信号通路驱动的过度增殖和肿瘤起始

Kanellos, Georgios; Giacomelli, Chiara; Raven, Alexander; Vlahov, Nikola; Jin, Hu; Herviou, Pauline; Malla, Sudhir B; Nasreddin, Nadia; Centeno, Patricia P; Alexandrou, Constantinos; Gilroy, Kathryn; Baird, Rachel L; Pennel, Kathryn; Munro, June; Waldron, Joseph A; Hall, Holly; Officer-Jones, Leah; Bryson, Sheila; Strathdee, Douglas; Lilla, Sergio; Zanivan, Sara; Morrison, Vivienne; Nixon, Colin; Ridgway, Rachel A; Miller, Crispin; Knight, John R P; Campbell, Andrew D; Dunne, Philip D; Le Quesne, John; Edwards, Joanne; Park, Peter J; Bushell, Martin; Sansom, Owen J

SOX2 confers tumour permissiveness in a specific skin progenitor population.

SOX2 赋予特定皮肤祖细胞群肿瘤易感性。

Centeno Patricia P, Chester Christopher, Kanellos Georgios, Ford Catriona A, Cammareri Patrizia, Inman Gareth J, Jamieson Thomas, Ridgway Rachel A, Marais Richard, Campbell Andrew D, Sansom Owen J

Therapeutic manipulation and spatial quantification of the tumor microenvironment in colorectal cancer.

结直肠癌肿瘤微环境的治疗性调控和空间定量分析。

Mulholland-Illingworth Eoghan J, Moore Joshua W, Lin Muyang, Amirkhah Raheleh, Grzesiak Lucile, Ligeza Amelia, Bull Joshua A, Boen Joseph, Valbuena Gabriel N, Gillespie Michael A, Lannagan Tamsin R M, Gilroy Kathryn, Mills Megan L, Corry Shania M, Ridgway Rachel A, Belnoue-Davis Hayley L, Dunne Philip D, Sansom Owen J, Byrne Helen M, Leedham Simon J

Inhibiting translation elongation by reducing eIF5A activity induces feedback inhibition of initiation, limiting tumour cell proliferation.

通过降低 eIF5A 活性来抑制翻译延伸,可诱导起始的反馈抑制,从而限制肿瘤细胞增殖。

Sfakianos Aristeidis P, Raven Rebecca M, Smith Tom, Sun Xiao-Ming, Mulroney Thomas E, Pizzinga Mariavittoria, Dezi Veronica, Tenor Angela Rubio, Stoneley Mark, Cole Cameron H, Al-Doori Karam, Nur Hashim Ahmed, Pennie Rachel L, Powley Ian, Officer-Jones Leah, Sawarkar Ritwick, Turner Martin, MacFarlane Marion, Sansom Owen J, Bushell Martin, Le Quesne John, Harvey Robert F, Willis Anne E

Enterocyte-like differentiation defines metabolic gene signatures of CMS3 colorectal cancers and provides therapeutic vulnerability.

肠细胞样分化定义了 CMS3 结直肠癌的代谢基因特征,并提供了治疗靶点

Torang Arezo, Kirov Aleksandar B, Lammers Veerle, Cameron Kate, Wouters Valérie M, Jackstadt Rene F, Lannagan Tamsin R M, de Jong Joan H, Koster Jan, Sansom Owen, Medema Jan Paul

Epithelial GREMLIN1 disrupts intestinal epithelial-mesenchymal crosstalk to induce a wnt-dependent ectopic stem cell niche through stromal remodelling.

上皮细胞 GREMLIN1 通过基质重塑破坏肠道上皮-间质细胞间的相互作用,从而诱导 Wnt 依赖性异位干细胞微环境

Mulholland Eoghan J, Belnoue-Davis Hayley L, Valbuena Gabriel N, Gunduz Nuray, Ligeza Amelia, Lin Muyang, Biswas Sujata, Gil Vasquez Ester, Omwenga Sulochana, Nasreddin Nadia, Hodder Michael C, Wang Lai Mun, Ng Aik Seng, Jennings Elizabeth, Midwood Kim S, Dedi Neesha, Irshad Shazia, Ridgway Rachel A, Phesse Toby J, East James, Tomlinson Ian Pm, Davies Gareth Cg, Sansom Owen J, Leedham Simon J

Corrigendum to Mutant p53-associated myosin-X upregulation promotes breast cancer invasion and metastasis

更正:突变型p53相关肌球蛋白X上调促进乳腺癌侵袭和转移

Arjonen, Antti; Kaukonen, Riina; Mattila, Elina; Rouhi, Pegah; Högnäs, Gunilla; Sihto, Harri; Miller, Bryan W; Morton, Jennifer P; Bucher, Elmar; Taimen, Pekka; Virtakoivu, Reetta; Cao, Yihai; Sansom, Owen J; Joensuu, Heikki; Ivaska, Johanna

CDX2 downregulation regulates intrinsic WNT pathway activation, dictating metastasis in APC and CTNNB1 wildtype colorectal cancer.

CDX2 下调调节内在 WNT 通路激活,决定 APC 和 CTNNB1 野生型结直肠癌的转移

Wouters Valérie M, Helderman Roxan F C P A, Cameron Kate, van der Hooff Sander R, Torang Arezo, van den Bergh Saskia, Jackstadt Rene, Sansom Owen J, van Neerven Sanne M, Medema Jan Paul

Colon cancer cells evade drug action by enhancing drug metabolism.

结肠癌细胞通过增强药物代谢来逃避药物作用

Cong Bojie, Thakur Teena, Uribe Alejandro Huerta, Stamou Evangelia, Gopinath Sindhura, Sansom Owen, Maddocks Oliver, Cagan Ross