日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A phase Ib study evaluating the recommended phase II dose, safety, tolerability, and efficacy of mivavotinib in combination with nivolumab in advanced solid tumors

一项 Ib 期研究评估了 mivavotinib 与 nivolumab 联合治疗晚期实体瘤的 II 期推荐剂量、安全性、耐受性和疗效。

Juric, Dejan; Barve, Minal; Vaishampayan, Ulka; Roda, Desamparados; Calvo, Aitana; Jañez, Noelia Martinez; Trigo, Jose; Greystoke, Alastair; Harvey, R Donald; Olszanski, Anthony J; Opyrchal, Mateusz; Spira, Alexander; Thistlethwaite, Fiona; Jiménez, Begoña; Sappal, Jessica Huck; Kannan, Karuppiah; Riley, Jason; Li, Cheryl; Li, Cong; Gregory, Richard C; Miao, Harry; Wang, Shining

Evaluation of Protein Kinase cAMP-Activated Catalytic Subunit Alpha as a Therapeutic Target for Fibrolamellar Carcinoma

评估蛋白激酶 cAMP 活化催化亚基 α 作为纤维板层癌治疗靶点

Stefanie S Schalm, Erin O'Hearn, Kevin Wilson, Timothy P LaBranche, Grace Silva, Zhuo Zhang, Lucian DiPietro, Neil Bifulco, Richard Woessner, Nicolas Stransky, Darshan Sappal, Robert Campbell, Riadh Lobbardi, Michael Palmer, Joseph Kim, Chaoyang Ye, Marion Dorsch, Christoph Lengauer, Timothy Guzi, V

A CDC7 inhibitor sensitizes DNA-damaging chemotherapies by suppressing homologous recombination repair to delay DNA damage recovery

CDC7 抑制剂通过抑制同源重组修复来延缓 DNA 损伤恢复,从而增强 DNA 损伤化疗的敏感性

Kenichi Iwai, Tadahiro Nambu, Yukie Kashima, Jie Yu, Kurt Eng, Kazumasa Miyamoto, Kazuyo Kakoi, Masamitsu Gotou, Toshiyuki Takeuchi, Akifumi Kogame, Jessica Sappal, Saomi Murai, Hiroshi Haeno, Shun-Ichiro Kageyama, Osamu Kurasawa, Huifeng Niu, Karuppiah Kannan, Akihiro Ohashi

Brown seaweed (AquaArom) supplementation increases food intake and improves growth, antioxidant status and resistance to temperature stress in Atlantic salmon, Salmo salar

补充褐藻(AquaArom)可增加大西洋鲑(Salmo salar)的摄食量,并改善其生长、抗氧化能力和对温度胁迫的抵抗力。

Kamunde, Collins; Sappal, Ravinder; Melegy, Tarek Mostafa

A small-molecule inhibitor of the ubiquitin activating enzyme for cancer treatment

用于癌症治疗的泛素活化酶小分子抑制剂

Marc L Hyer, Michael A Milhollen, Jeff Ciavarri, Paul Fleming, Tary Traore, Darshan Sappal, Jessica Huck, Judy Shi, James Gavin, Jim Brownell, Yu Yang, Bradley Stringer, Robert Griffin, Frank Bruzzese, Teresa Soucy, Jennifer Duffy, Claudia Rabino, Jessica Riceberg, Kara Hoar, Anya Lublinsky, Saurabh

Spleen Tyrosine Kinase Inhibitor TAK-659 Prevents Splenomegaly and Tumor Development in a Murine Model of Epstein-Barr Virus-Associated Lymphoma

脾脏酪氨酸激酶抑制剂 TAK-659 可预防小鼠 Epstein-Barr 病毒相关淋巴瘤模型中的脾肿大和肿瘤发展

Osman Cen, Karuppiah Kannan, Jessica Huck Sappal, Jie Yu, Mengkun Zhang, Muzaffer Arikan, Ali Ucur, Duran Ustek, Yeter Cen, Leo Gordon, Richard Longnecker

IFN-γ orchestrates tumor elimination, tumor dormancy, tumor escape, and progression

IFN-γ 调控肿瘤清除、肿瘤休眠、肿瘤逃逸和肿瘤进展。

Aqbi, Hussein F; Wallace, Matthew; Sappal, Samay; Payne, Kyle K; Manjili, Masoud H

Nedd8-activating enzyme inhibitor MLN4924 provides synergy with mitomycin C through interactions with ATR, BRCA1/BRCA2, and chromatin dynamics pathways

Nedd8 活化酶抑制剂 MLN4924 通过与 ATR、BRCA1/BRCA2 和染色质动力学通路相互作用,与丝裂霉素 C 产生协同作用

Khristofer Garcia, Jonathan L Blank, David C Bouck, Xiaozhen J Liu, Darshan S Sappal, Greg Hather, Katherine Cosmopoulos, Michael P Thomas, Mike Kuranda, Michael D Pickard, Ray Liu, Syamala Bandi, Peter G Smith, Eric S Lightcap

Characterization of a new series of non-covalent proteasome inhibitors with exquisite potency and selectivity for the 20S beta5-subunit

对一系列新型非共价蛋白酶体抑制剂进行表征,这些抑制剂对 20S β5 亚基具有极高的效力和选择性。

Blackburn, Christopher; Gigstad, Kenneth M; Hales, Paul; Garcia, Khristofer; Jones, Matthew; Bruzzese, Frank J; Barrett, Cynthia; Liu, Jane X; Soucy, Teresa A; Sappal, Darshan S; Bump, Nancy; Olhava, Edward J; Fleming, Paul; Dick, Lawrence R; Tsu, Christopher; Sintchak, Michael D; Blank, Jonathan L

Endogenous spartin (SPG20) is recruited to endosomes and lipid droplets and interacts with the ubiquitin E3 ligases AIP4 and AIP5

内源性斯巴汀(SPG20)被募集到内体和脂滴中,并与泛素E3连接酶AIP4和AIP5相互作用。

Bastea, Ligia I; Döppler, Heike; Pearce, Sarah E; Durand, Nisha; Spratley, Samantha J; Storz, Peter; Nordin, N; Guskov, A; Phua, T; Sahaf, N; Xia, Y; Lu, S; Eshaghi, H; Eshaghi, S; O'Leary, B; Rao, S K; Plaxton, W C; Blackburn, C; Gigstad, K M; Hales, P; Garcia, K; Jones, M; Bruzzese, F J; Barrett, C; Liu, J X; Soucy, T A; Sappal, D S; Bump, N; Olhava, E J; Fleming, P; Dick, L R; Tsu, C; Sintchak, M D; Blank, J L; Nomikos, M; Elgmati, K; Theodoridou, M; Calver, B L; Cumbes, B; Nounesis, G; Swann, K; Lai, F A; Brand, M D; Nicholls, D G; Edwards, T L; Clowes, V E; Tsang, H T H; Connell, J W; Sanderson, C M; Luzio, J P; Reid, E