日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

LRRK2 kinase activity regulates Parkinson's disease-relevant lipids at the lysosome

LRRK2激酶活性调节溶酶体中与帕金森病相关的脂质

Michael T Maloney # ,Xiang Wang # ,Rajarshi Ghosh ,Shan V Andrews ,Romeo Maciuca ,Shababa T Masoud ,Maayan Agam ,Richard M Caprioli ,Giuseppe Astarita ,Vitaliy V Bondar ,John Chen ,Chi-Lu Chiu ,Sonnet S Davis ,Audrey Cheuk-Nga Ho ,Hoang N Nguyen ,Nicholas E Propson ,Michelle L Reyzer ,Oliver B Davis ,Matthew C Deen ,Sha Zhu ,Gilbert Di Paolo ,David J Vocadlo ,Anthony A Estrada ,Javier de Vicente ,Joseph W Lewcock ,Annie Arguello ,Jung H Suh ,Sarah Huntwork-Rodriguez ,Anastasia G Henry

A leucine-rich repeat kinase 2 (LRRK2) pathway biomarker characterization study in patients with Parkinson's disease with and without LRRK2 mutations and healthy controls

针对患有和不患有 LRRK2 突变的帕金森病患者和健康对照者的富含亮氨酸重复激酶 2 (LRRK2) 通路生物标志物表征研究

Maurits F J M Vissers, Matthew D Troyer, Eva Thijssen, Diana R Pereira, Jules A A C Heuberger, Geert Jan Groeneveld, Sarah Huntwork-Rodriguez

Understanding LRRK2 kinase activity in preclinical models and human subjects through quantitative analysis of LRRK2 and pT73 Rab10

通过对 LRRK2 和 pT73 Rab10 进行定量分析,了解临床前模型和人体受试者中 LRRK2 激酶活性

Xiang Wang ,Elvira Negrou ,Michael T Maloney ,Vitaliy V Bondar ,Shan V Andrews ,Manuel Montalban ,Ceyda Llapashtica ,Romeo Maciuca ,Hoang Nguyen ,Hilda Solanoy ,Annie Arguello ,Laralynne Przybyla ,Nathan J Moerke ,Sarah Huntwork-Rodriguez ,Anastasia G Henry

Dual leucine zipper kinase-dependent PERK activation contributes to neuronal degeneration following insult

双亮氨酸拉链激酶依赖性 PERK 激活导致损伤后的神经元变性

Martin Larhammar, Sarah Huntwork-Rodriguez, Zhiyu Jiang, Hilda Solanoy, Arundhati Sengupta Ghosh, Bei Wang, Joshua S Kaminker, Kevin Huang, Jeffrey Eastham-Anderson, Michael Siu, Zora Modrusan, Madeline M Farley, Marc Tessier-Lavigne, Joseph W Lewcock, Trent A Watkins

The Ste20 Family Kinases MAP4K4, MINK1, and TNIK Converge to Regulate Stress-Induced JNK Signaling in Neurons

Ste20 家族激酶 MAP4K4、MINK1 和 TNIK 共同调节应激诱导的神经元 JNK 信号传导

Martin Larhammar, Sarah Huntwork-Rodriguez, York Rudhard, Arundhati Sengupta-Ghosh, Joseph W Lewcock

JNK-mediated phosphorylation of DLK suppresses its ubiquitination to promote neuronal apoptosis

JNK介导的DLK磷酸化抑制其泛素化从而促进神经元凋亡

Sarah Huntwork-Rodriguez, Bei Wang, Trent Watkins, Arundhati Sengupta Ghosh, Christine D Pozniak, Daisy Bustos, Kim Newton, Donald S Kirkpatrick, Joseph W Lewcock