日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Drug-resistant EGFR mutations promote lung cancer by stabilizing interfaces in ligand-free kinase-active EGFR oligomers

耐药性EGFR突变通过稳定无配体激酶活性EGFR寡聚体中的界面来促进肺癌的发生。

R Sumanth Iyer # ,Sarah R Needham # ,Ioannis Galdadas # ,Benjamin M Davis # ,Selene K Roberts # ,Rico C H Man ,Laura C Zanetti-Domingues ,David T Clarke ,Gilbert O Fruhwirth ,Peter J Parker ,Daniel J Rolfe ,Francesco L Gervasio ,Marisa L Martin-Fernandez

The use of NADH anisotropy to investigate mitochondrial cristae alignment

利用 NADH 各向异性研究线粒体嵴排列

Holly E Smith, Alasdair M Mackenzie, Chloe Seddon, Rhys Mould, Ifi Kalampouka, Partha Malakar, Sarah R Needham, Konstantinos Beis, Jimmy D Bell, Alistair Nunn, Stanley W Botchway

Directly imaging the localisation and photosensitization properties of the pan-mTOR inhibitor, AZD2014, in living cancer cells

直接成像泛 mTOR 抑制剂 AZD2014 在活癌细胞中的定位和光敏特性

Abdullah R Ahmed, Alessia Candeo, Sofia D'Abrantes, Sarah R Needham, Rahul B Yadav, Stanley W Botchway, Anthony W Parker

Solid immersion microscopy images cells under cryogenic conditions with 12 nm resolution

固体浸没显微镜在低温条件下以 12 纳米分辨率对细胞进行成像

Lin Wang, Benji Bateman, Laura C Zanetti-Domingues, Amy N Moores, Sam Astbury, Christopher Spindloe, Michele C Darrow, Maria Romano, Sarah R Needham, Konstantinos Beis, Daniel J Rolfe, David T Clarke, Marisa L Martin-Fernandez

Super-resolution Microscopy at Cryogenic Temperatures Using Solid Immersion Lenses

使用固体浸没透镜的低温超分辨率显微镜

Benji C Bateman, Laura C Zanetti-Domingues, Amy N Moores, Sarah R Needham, Daniel J Rolfe, Lin Wang, David T Clarke, Marisa L Martin-Fernandez

The architecture of EGFR's basal complexes reveals autoinhibition mechanisms in dimers and oligomers

EGFR 基底复合物的结构揭示了二聚体和低聚物中的自身抑制机制

Laura C Zanetti-Domingues, Dimitrios Korovesis, Sarah R Needham, Christopher J Tynan, Shiori Sagawa, Selene K Roberts, Antonija Kuzmanic, Elena Ortiz-Zapater, Purvi Jain, Rob C Roovers, Alireza Lajevardipour, Paul M P van Bergen En Henegouwen, George Santis, Andrew H A Clayton, David T Clarke, Franc

Affimer proteins are versatile and renewable affinity reagents

亲和蛋白是一种多功能且可再生的亲和试剂

Christian Tiede, Robert Bedford, Sophie J Heseltine, Gina Smith, Imeshi Wijetunga, Rebecca Ross, Danah AlQallaf, Ashley Pe Roberts, Alexander Balls, Alistair Curd, Ruth E Hughes, Heather Martin, Sarah R Needham, Laura C Zanetti-Domingues, Yashar Sadigh, Thomas P Peacock, Anna A Tang, Naomi Gibson, H

EGFR oligomerization organizes kinase-active dimers into competent signalling platforms

EGFR寡聚化将激酶活性二聚体组织成有效的信号传导平台

Sarah R Needham, Selene K Roberts, Anton Arkhipov, Venkatesh P Mysore, Christopher J Tynan, Laura C Zanetti-Domingues, Eric T Kim, Valeria Losasso, Dimitrios Korovesis, Michael Hirsch, Daniel J Rolfe, David T Clarke, Martyn D Winn, Alireza Lajevardipour, Andrew H A Clayton, Linda J Pike, Michela Per