日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

MTBVAC induces superior antibody titers and IgG avidity compared to BCG vaccination in non-human primates

在非人灵长类动物中,与卡介苗相比,MTBVAC 可诱导更高的抗体滴度和 IgG 亲和力。

Peralta-Álvarez, Marco Polo; Downward, Keya; White, Andrew; Redondo Azema, Hugo; Sibley, Laura; Sarfas, Charlotte; Morrison, Alexandra; Dennis, Mike; Diaz-Santana, Delia; Harris, Stephanie A; Li, Shuailin; Puentes, Eugenia; Aguilo, Nacho; Martin, Carlos; Sharpe, Sally; McShane, Helen; Tanner, Rachel

Low-dose M.tb infection but not BCG or MTBVAC vaccination enhances heterologous antibody titres in non-human primates

低剂量结核分枝杆菌感染而非 BCG 或 MTBVAC 疫苗接种可增强非人类灵长类动物的异源抗体滴度

Marco Polo Peralta Alvarez, Holly Jones, Hugo Redondo Azema, Chloe Davis, Andrew D White, Charlotte Sarfas, Mike Dennis, Shuailin Li, Daniel Wright, Eugenia Puentes, Simon Kimuda, Sandra Belij-Rammerstorfer, Nacho Aguilo, Carlos Martin, Sally Sharpe, Helen McShane, Rachel Tanner

Immune cell population dynamics following neonatal BCG vaccination and aerosol BCG revaccination in rhesus macaques

恒河猴新生儿接种卡介苗及气溶胶卡介苗复种后免疫细胞群体动态变化

Sibley, Laura; Sarfas, Charlotte; Morrison, Alexandra L; Williams, Jessica; Gkolfinos, Konstantinos; Mabbutt, Adam; Eckworth, William; Lawrence, Steve; Dennis, Mike; White, Andrew; Sharpe, Sally

Intravenous BCG vaccination in non-human primates induces superior serum antibody titers with enhanced avidity and opsonizing capacity compared to the intradermal route

与皮内注射途径相比,非人灵长类动物静脉注射卡介苗可诱导产生更高滴度的血清抗体,且抗体具有更强的亲和力和调理能力。

Peralta Alvarez, Marco Polo; Downward, Keya; White, Andrew; Harris, Stephanie A; Satti, Iman; Li, Shuailin; Morrison, Alexandra; Sibley, Laura; Sarfas, Charlotte; Dennis, Mike; Azema, Hugo Redondo; Sharpe, Sally; McShane, Helen; Tanner, Rachel

Spore-FP1 tuberculosis mucosal vaccine candidate is highly protective in guinea pigs but fails to improve on BCG-conferred protection in non-human primates

Spore-FP1 结核病粘膜候选疫苗对豚鼠具有高度保护作用,但未能提高 BCG 对非人类灵长类动物的保护作用

Andrew D White, Andy C Tran, Laura Sibley, Charlotte Sarfas, Alexandra L Morrison, Steve Lawrence, Mike Dennis, Simon Clark, Sirine Zadi, Faye Lanni, Emma Rayner, Alastair Copland, Peter Hart, Gil Reynolds Diogo, Matthew J Paul, Miyoung Kim, Fergus Gleeson, Francisco J Salguero, Mahavir Singh, Matth

IV BCG Vaccination and Aerosol BCG Revaccination Induce Mycobacteria-Responsive γδ T Cells Associated with Protective Efficacy against M. tb Challenge

静脉注射 BCG 疫苗和气雾剂 BCG 再接种可诱导对分枝杆菌有反应性的 γδT 细胞,与抵抗结核分枝杆菌攻击的保护效力相关

Alexandra L Morrison, Charlotte Sarfas, Laura Sibley, Jessica Williams, Adam Mabbutt, Mike J Dennis, Steve Lawrence, Andrew D White, Mark Bodman-Smith, Sally A Sharpe

Influence of Aerosol Delivered BCG Vaccination on Immunological and Disease Parameters Following SARS-CoV-2 Challenge in Rhesus Macaques

气雾剂递送 BCG 疫苗对恒河猴感染 SARS-CoV-2 后免疫学和疾病参数的影响

Andrew D White, Laura Sibley, Charlotte Sarfas, Alexandra L Morrison, Kevin Bewley, Colin Churchward, Susan Fotheringham, Konstantinos Gkolfinos, Karen Gooch, Alastair Handley, Holly E Humphries, Laura Hunter, Chelsea Kennard, Stephanie Longet, Adam Mabbutt, Miriam Moffatt, Emma Rayner, Tom Tipton, 

Determination of the Pharmacokinetics and Pharmacodynamics of Isoniazid, Rifampicin, Pyrazinamide and Ethambutol in a Cross-Over Cynomolgus Macaque Model of Mycobacterium tuberculosis Infection

在交叉食蟹猴结核分枝杆菌感染模型中测定异烟肼、利福平、吡嗪酰胺和乙胺丁醇的药代动力学和药效学

Sibley, Laura; White, Andrew D; Sarfas, Charlotte; Gullick, Jennie; Gleeson, Fergus; Lanni, Faye; Clark, Simon; Rayner, Emma; Ferrer-Bazaga, Santiago; Ortega-Muro, Fatima; Alameda, Laura; Rullas, Joaquin; Sousa, Veronica; Martinez, Marisa; Angulo-Barturen, Inigo; Garcia, Adolfo; Vaquero, Juan José; Pertinez, Henry E; Davies, Geraint; Dennis, Mike; Williams, Ann; Sharpe, Sally

Identification of HLA-E Binding Mycobacterium tuberculosis-Derived Epitopes through Improved Prediction Models

通过改进的预测模型鉴定结核分枝杆菌衍生的HLA-E结合表位

Ruibal, Paula; Franken, Kees L M C; van Meijgaarden, Krista E; van Wolfswinkel, Marjolein; Derksen, Ian; Scheeren, Ferenc A; Janssen, George M C; van Veelen, Peter A; Sarfas, Charlotte; White, Andrew D; Sharpe, Sally A; Palmieri, Fabrizio; Petrone, Linda; Goletti, Delia; Abeel, Thomas; Ottenhoff, Tom H M; Joosten, Simone A

Bacillus Calmette-Guerin (BCG) induces superior anti-tumour responses by Vδ2+ T cells compared with the aminobisphosphonate drug zoledronic acid

与氨基双膦酸盐类药物唑来膦酸相比,卡介苗(BCG)能诱导Vδ2+ T细胞产生更强的抗肿瘤反应。

J Fenn ,L A Ridgley ,A White ,C Sarfas ,M Dennis ,A Dalgleish ,R Reljic ,S Sharpe ,M Bodman-Smith