日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Real-Time Optical Control of CB1 Receptor Signaling In Vitro with Tethered Photoswitchable (-)-trans-Δ(9)-Tetrahydrocannabinol Derivatives

利用系链光开关(-)-反式-Δ(9)-四氢大麻酚衍生物对体外CB1受体信号传导进行实时光学控制

Garza, Sarahi J; Kicin, Bilal; Sarott, Roman C; Pfaff, Patrick; Kosar, Miroslav; Weishaar, Tatum; Schnacke, Paul; Lobingier, Braden T; Carreira, Erick M; Frank, James A

Rewiring the Fusion Oncoprotein EWSR1::FLI1 in Ewing Sarcoma with Bivalent Small Molecules.

利用二价小分子对尤文氏肉瘤中的融合癌蛋白 EWSR1::FLI1 进行重新连接。

Bond Michael J, Golden Ryan P, DiGiovanni Giulia, Howard Briana, Sarott Roman C, Karim Basel A, Gourisankar Sai, Alexe Gabriela, Ross Kenneth, Jones Hannah M, Dwyer Brendan G, Gray Nathanael S, Stegmaier Kimberly

Development of Potent and Selective CK1α Molecular Glue Degraders.

高效选择性CK1α分子胶降解剂的开发。

Geng Qixiang, Jiang Zixuan, Byun Woong Sub, Donovan Katherine A, Zhuang Zhe, Jiang Fen, Jones Hannah M, Razumkov Hlib, Tang Michelle T, Sarott Roman C, Fischer Eric S, Corsello Steven M, Hinshaw Stephen M, Gray Nathanael S

A universal cannabinoid CB1 and CB2 receptor TR-FRET kinetic ligand-binding assay.

一种通用的大麻素 CB1 和 CB2 受体 TR-FRET 动力学配体结合测定法

Borrega-Roman Leire, Hoare Bradley L, Kosar Miroslav, Sarott Roman C, Patej Kacper J, Bouma Jara, Scott-Dennis Morgan, Koers Eline J, Gazzi Thais, Mach Leonard, Barrondo Sergio, Sallés Joan, Guba Wolfgang, Kusznir Eric, Nazaré Marc, Rufer Arne C, Grether Uwe, Heitman Laura H, Carreira Erick M, Sykes David A, Veprintsev Dmitry B

Rewiring the fusion oncoprotein EWS/FLI1 in Ewing sarcoma with bivalent small molecules

利用二价小分子对尤文氏肉瘤中的融合癌蛋白 EWS/FLI1 进行重新连接

Bond, Michael J; Golden, Ryan P; DiGiovanni, Giulia; Howard, Briana; Sarott, Roman C; Karim, Basel A; Gourisankar, Sai; Alexe, Gabriela; Ross, Kenneth; Gray, Nathanael S; Stegmaier, Kimberly

A Bivalent Molecular Glue Linking Lysine Acetyltransferases to Oncogene-induced Cell Death.

将赖氨酸乙酰转移酶与癌基因诱导的细胞死亡联系起来的二价分子胶

Nix Meredith N, Gourisankar Sai, Sarott Roman C, Dwyer Brendan G, Nettles Sabin A, Martinez Michael M, Abuzaid Hind, Yang Haopeng, Wang Yanlan, Simanauskaite Juste M, Romero Bryan A, Jones Hannah M, Krokhotin Andrey, Lowensohn Tara N, Chen Lei, Low Cara, Davis Mark M, Fernandez Daniel, Zhang Tinghu, Green Michael R, Hinshaw Stephen M, Gray Nathanael S, Crabtree Gerald R

Relocalizing transcriptional kinases to activate apoptosis.

重新定位转录激酶以激活细胞凋亡

Sarott Roman C, Gourisankar Sai, Karim Basel, Nettles Sabin, Yang Haopeng, Dwyer Brendan G, Simanauskaite Juste M, Tse Jason, Abuzaid Hind, Krokhotin Andrey, Zhang Tinghu, Hinshaw Stephen M, Green Michael R, Crabtree Gerald R, Gray Nathanael S

Discovery of CRBN-Dependent WEE1 Molecular Glue Degraders from a Multicomponent Combinatorial Library

从多组分组合库中发现 CRBN 依赖性 WEE1 分子胶降解剂

Razumkov, Hlib; Jiang, Zixuan; Baek, Kheewoong; You, Inchul; Geng, Qixiang; Donovan, Katherine A; Tang, Michelle T; Metivier, Rebecca J; Mageed, Nada; Seo, Pooreum; Li, Zhengnian; Byun, Woong Sub; Hinshaw, Stephen M; Sarott, Roman C; Fischer, Eric S; Gray, Nathanael S

Flipping the GPCR Switch: Structure-Based Development of Selective Cannabinoid Receptor 2 Inverse Agonists

翻转GPCR开关:基于结构的选择性大麻素受体2反向激动剂的开发

Kosar, Miroslav; Sarott, Roman C; Sykes, David A; Viray, Alexander E G; Vitale, Rosa Maria; Tomašević, Nataša; Li, Xiaoting; Ganzoni, Rudolf L Z; Kicin, Bilal; Reichert, Lisa; Patej, Kacper J; Gómez-Bouzó, Uxía; Guba, Wolfgang; McCormick, Peter J; Hua, Tian; Gruber, Christian W; Veprintsev, Dmitry B; Frank, James A; Grether, Uwe; Carreira, Erick M

Activating p53(Y220C) with a Mutant-Specific Small Molecule.

用突变体特异性小分子激活p53(Y220C)

Zhu Xijun, Byun Woong Sub, Pieńkowska Dominika Ewa, Nguyen Kha The, Gerhartz Jan, Geng Qixiang, Qiu Tian, Zhong Jianing, Jiang Zixuan, Wang Mengxiong, Sarott Roman C, Hinshaw Stephen M, Zhang Tinghu, Attardi Laura D, Nowak Radosław P, Gray Nathanael S