日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Therapeutic targeting of chromatin alterations in leukemia and solid tumors

针对白血病和实体瘤染色质改变的治疗靶向治疗

Perner, Florian; Berg, Tobias; Sasca, Daniel; Mersiowsky, Sophie-Luise; Gadrey, Jayant Y; Thomas, Johanna; Kühn, Michael W M; Lübbert, Michael

Evidence of miR‐153‐3p association with Alzheimer's disease (AD) and the mechanism of miR‐153‐3p on critical proteins suggest a therapeutic and biomarker potential of miR‐153‐3p in AD and related dementias

miR-153-3p与阿尔茨海默病(AD)的关联证据以及miR-153-3p对关键蛋白的作用机制表明,miR-153-3p在AD及相关痴呆症中具有治疗和生物标志物方面的潜力。

Shah, Viral; Giotopoulos, George; Osaki, Hikari; Meyerhöfer, Markus; Meduri, Eshwar; Gallego-Crespo, Aaron; Behrendt, Malte A; Saura-Pañella, Maria; Tarkar, Aarti; Schubert, Benedict; Yun, Haiyang; Horton, Sarah J; Agrawal-Singh, Shuchi; Haehnel, Patricia S; Basheer, Faisal; Lugo, Dave; Eleftheriadou, Ioanna; Barbash, Olena; Dhar, Arindam; Kühn, Michael W M; Guezguez, Borhane; Theobald, Matthias; Kindler, Thomas; Gallipoli, Paolo; Yeh, Paul; Dawson, Mark A; Prinjha, Rab K; Huntly, Brian J P; Sasca, Daniel; Fish, Lauren A; Canchi, Saranya; Telpoukhovskaia, Maria; Luquez, Tain; Algoo, Jonathan; Hadad, Niran; Gurdon, Brianna; Dai, Miko; Ouellette, Andrew R; Neuner, Sarah M; Dunn, Amy R; Willcox, Jon A L; Wu, Yiyang; Dumitrescu, Logan; Bellur, Orhan; Zhang, Jigang; O'Connell, Kristen MS; Dammer, Eric B; Seyfried, Nicholas T; Muzumdar, Sukalp; Gillis, Jesse; Robson, Paul; Arnold, Matthias; Hohman, Timothy J; Philip, Vivek M; Menon, Vilas; Kaczorowski, Catherine C; Lahiri, Debomoy K; Wang, Ruizhi; Maloney, Bryan; Ghetti, Bernardino; Nho, Kwangsik; Farlow, Martin R; Saykin, Andrew J; White, Fletcher A; Sambamurti, Kumar; Counts, Scott E; Rosene, Matthew J; Lopez, Abraham; Ahmad, Adeeb; Romero, Skarleth Cardenas; Lai, Mei‐Yu; Benitez, Bruno A; Tish, Margaret M; Gao, Lauren; Ou, Zihui; Weinshenker, David; Birey, Fikri; Lahiri, Debomoy K; Wang, Ruizhi; Maloney, Bryan; Ghetti, Bernardino; Nho, Kwangsik; Farlow, Martin R; Saykin, Andrew J; White, Fletcher A; Sambamurti, Kumar; Counts, Scott E

Minor Visual Phenomena in Lewy Body Disease: A Systematic Review

路易体病轻微视觉现象:系统性综述

Capogna, Elettra; Pollarini, Virginia; Quinzi, Alessia; Guidi, Lucia; Sambati, Luisa; Criante, Maria Sasca; Mengoli, Elena; Venneri, Annalena; Lodi, Raffaele; Tonon, Caterina; Mitolo, Micaela

HOXA9 forms a repressive complex with nuclear matrix-associated protein SAFB to maintain acute myeloid leukemia

HOXA9 与核基质相关蛋白 SAFB 形成抑制复合物,以维持急性髓系白血病。

Agrawal-Singh, Shuchi; Bagri, Jaana; Giotopoulos, George; Azazi, Dhoyazan M A; Horton, Sarah J; Lopez, Cecile K; Anand, Shubha; Bach, Anne-Sophie; Stedham, Frances; Antrobus, Robin; Houghton, Jack W; Vassiliou, George S; Sasca, Daniel; Yun, Haiyang; Whetton, Anthony D; Huntly, Brian J P

Menin inhibitor ziftomenib (KO-539) synergizes with drugs targeting chromatin regulation or apoptosis and sensitizes acute myeloid leukemia with MLL rearrangement or NPM1 mutation to venetoclax

Menin抑制剂ziftomenib (KO-539) 与靶向染色质调控或细胞凋亡的药物具有协同作用,并能增强MLL重排或NPM1突变的急性髓系白血病对维奈托克的敏感性。

Rausch, Johanna; Dzama, Margarita M; Dolgikh, Nadezda; Stiller, Hanna L; Bohl, Stephan R; Lahrmann, Catharina; Kunz, Kerstin; Kessler, Linda; Echchannaoui, Hakim; Chen, Chun-Wei; Kindler, Thomas; Döhner, Konstanze; Burrows, Francis; Theobald, Matthias; Sasca, Daniel; Kühn, Michael W M

Mutational synergy during leukemia induction remodels chromatin accessibility, histone modifications and three-dimensional DNA topology to alter gene expression

白血病诱导过程中的突变协同作用重塑了染色质的可及性、组蛋白修饰和三维 DNA 拓扑结构,从而改变了基因表达

Haiyang Yun, Nisha Narayan, Shabana Vohra, George Giotopoulos, Annalisa Mupo, Pedro Madrigal, Daniel Sasca, David Lara-Astiaso, Sarah J Horton, Shuchi Agrawal-Singh, Eshwar Meduri, Faisal Basheer, Ludovica Marando, Malgorzata Gozdecka, Oliver M Dovey, Aracely Castillo-Venzor, Xiaonan Wang, Paolo Gal

Pandemic Spread of COVID-19 Mutant Variants Will Facilitate Next-generation Sequencing Capacities for Personalised Medicine in Urologic Oncology

COVID-19 变异株的全球传播将促进泌尿肿瘤个性化医疗领域下一代测序技术的发展

Borgmann, Hendrik; Höfner, Thomas; Sasca, Daniel; Porubsky, Stefan; Tsaur, Igor; Haferkamp, Axel; Dotzauer, Robert

Synergistic targeting of FLT3 mutations in AML via combined menin-MLL and FLT3 inhibition

通过联合抑制menin-MLL和FLT3,协同靶向治疗AML中的FLT3突变

Dzama, Margarita M; Steiner, Marlene; Rausch, Johanna; Sasca, Daniel; Schönfeld, Jonas; Kunz, Kerstin; Taubert, Martha C; McGeehan, Gerard M; Chen, Chun-Wei; Mupo, Annalisa; Hähnel, Patricia; Theobald, Matthias; Kindler, Thomas; Koche, Richard P; Vassiliou, George S; Armstrong, Scott A; Kühn, Michael W M

Cohesin-dependent regulation of gene expression during differentiation is lost in cohesin-mutated myeloid malignancies

在黏连蛋白突变的髓系恶性肿瘤中,分化过程中黏连蛋白依赖的基因表达调控丧失

Daniel Sasca, Haiyang Yun, George Giotopoulos, Jakub Szybinski, Theo Evan, Nicola K Wilson, Moritz Gerstung, Paolo Gallipoli, Anthony R Green, Robert Hills, Nigel Russell, Cameron S Osborne, Elli Papaemmanuil, Berthold Göttgens, Peter Campbell, Brian J P Huntly

Contrasting requirements during disease evolution identify EZH2 as a therapeutic target in AML

疾病发展过程中的对比要求确定 EZH2 是 AML 的治疗靶点

Faisal Basheer, George Giotopoulos, Eshwar Meduri, Haiyang Yun, Milena Mazan, Daniel Sasca, Paolo Gallipoli, Ludovica Marando, Malgorzata Gozdecka, Ryan Asby, Olivia Sheppard, Monika Dudek, Lars Bullinger, Hartmut Döhner, Richard Dillon, Sylvie Freeman, Oliver Ottmann, Alan Burnett, Nigel Russell, E