日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Ageing promotes microglial accumulation of slow-degrading synaptic proteins.

衰老会促进小胶质细胞中缓慢降解的突触蛋白的积累。

Guldner Ian H, Wagner Viktoria P, Moran-Losada Patricia, Shi Sophia M, Golub Sophia W, Hevler Johannes F, Chen Kelly, Meese Barbara T, Ghoochani Ali, Pulido Ernst, Oh Hamilton Se-Hwee, Le Guen Yann, Lu Nannan, Wong Pui Shuen, To Ning-Sum, Garceau Dylan, Guo Zimin, Luo Jian, Bertozzi Carolyn R, Lundberg Emma, Abu-Remaileh Monther, Sasner Michael, Keller Andreas, Yang Andrew C, Cheung Tom H, Wyss-Coray Tony

Author Correction: Perivascular cells induce microglial phagocytic states and synaptic engulfment via SPP1 in mouse models of Alzheimer's disease

作者更正:在阿尔茨海默病小鼠模型中,血管周围细胞通过SPP1诱导小胶质细胞吞噬状态和突触吞噬。

De Schepper, Sebastiaan; Ge, Judy Z; Sierksma, Annerieke; Crowley, Gerard; Ferreira, Laís S S; Garceau, Dylan; Toomey, Christina E; Sokolova, Dimitra; Rueda-Carrasco, Javier; Shin, Sun-Hye; Kim, Jung-Seok; Childs, Thomas; Lashley, Tammaryn; Burden, Jemima J; Sasner, Michael; Sala Frigerio, Carlo; Jung, Steffen; Hong, Soyon

Exploring connectedness as a source of cognitive resilience in Black middle‐aged and older adults: Social support, plasma p‐tau217, and cognition

探索联结感作为黑人中老年人认知韧性的来源:社会支持、血浆p-tau217和认知

Sanchiz-Calvo, María; Coccia, Elena; Cawthorne, Christopher; Morrone Parfitt, Gustavo; Torre-Muruzabal, Teresa; Tsafaras, George; Van Laere, Koen; Cabezudo, Diego; Cascalho, Ana; Van den Haute, Chris; Vangheluwe, Peter; Blanchard, Joel; Bentea, Eduard; Baekelandt, Veerle; Howell, Gareth R; Garceau, Dylan; Kotredes, Kevin P; Pandey, Ravi S; Spruce, Catrina; Burman, Alison; Carter, Gregory W; Sasner, Michael; Zuelsdorff, Megan L

Examining comprehensive spatial and temporal amyloid deposition in brain and retina of hAbeta(SAA) knockin mice

对hAβ(SAA)敲入小鼠的大脑和视网膜中淀粉样蛋白沉积进行全面的时空分析

Watanabe, Memi; Shrivastava, Raj K; Balchandani, Priti; Palta, Priya; Pike, James Russell; Lu, Yifei; Walker, Keenan A; Sullivan, Kevin J; Windham, Gwen Gwen; Thyagarajan, Bharat; Mielke, Michelle M; Lutsey, Pamela L; Hughes, Timothy M; Knopman, David S; Sharrett, A Richey; Gottesman, Rebecca F; Mosley, Thomas H Jr; Coresh, Josef; Reagan, Alaina M; Marola, Olivia J; Sasner, Michael; Howell, Gareth R

Multi‐Omics analysis identifies that different genetic perturbations affect various molecular mechanisms underlying Alzheimer's Disease (AD) in an age‐dependent manner

多组学分析表明,不同的基因扰动会以年龄依赖的方式影响阿尔茨海默病(AD)的各种分子机制。

Miki, Takafumi; Pandey, Ravi S; Kotredes, Kevin P; Garceau, Dylan; Spruce, Catrina; Shantaraman, Anantharaman; Duong, Duc M; Paisie, Carolyn; Seyfried, Nicholas T; Rangel‐Barajas, Claudia; Sasner, Michael; Oblak, Adrian L; Howell, Gareth R; Lamb, Bruce T; Carter, Gregory W

A1527G variant of ABCA7 increases soluble and insoluble Aβ40‐42 in an animal model for late‐onset Alzheimer's disease

ABCA7 的 A1527G 变体在晚发性阿尔茨海默病动物模型中增加可溶性和不溶性 Aβ40-42

Sampath, Nishanth; Raghavendra, Sunil Kapilavayi; Ratha, Vishwaraj; Sivakumar, Gomathi; Sankaran, Vijay; Suresh Bapu, K R; Bernabe, Cristian S; Kotredes, Kevin P; Pandey, Ravi S; Carter, Gregory W; Sasner, Michael; Oblak, Adrian L; Howell, Gareth R; Lamb, Bruce T; Territo, Paul R

Humanized Klotho variants cause widespread transcriptional changes in B6 mice

人源化Klotho变体导致B6小鼠出现广泛的转录变化

Mishra, Archana; Knerr, Boris; Paixão, Sónia; Kramer, Edgar R; Klein, Rüdiger; Tyler, Anna L; Garceau, Dylan; Kotredes, Kevin P; Preuss, Christoph; Sasner, Michael; Carter, Gregory W

Trem2(R47H) and reduced TREM2 expression both mimic human Alzheimer's disease signatures in mice

Trem2(R47H) 和 TREM2 表达降低均可在小鼠中模拟人类阿尔茨海默病特征。

Abel, Tamar R; Pandey, Ravi S; Haber, Annat; Garceau, Dylan; Sasner, Michael; Kotredes, Kevin P; Cary, Gregory A; Oblak, Adrian; Howell, Gareth R; Lamb, Bruce T; Carter, Gregory W

WSB.APP/PS1 mice develop age-dependent cerebral amyloid angiopathy, cerebrovascular deficits, and white matter damage, which are modified by humanized APOE alleles.

WSB.APP/PS1 小鼠会患上与年龄相关的脑淀粉样血管病、脑血管缺陷和白质损伤,而这些症状可以通过人源化 APOE 等位基因进行修饰。

Onos Kristen D, Marola Olivia J, Uyar Asli, Keezer Kelly J, Chong Chie Juan Antonio K, Elk Kevin, Bohn Phillip, Cullen Abigail E, Eldridge Kierra, Persohn Scott, Kanyinda Jonathan Nyandu, Kocalis Heidi K, Whitesell Jennifer D, Harris Julie A, Salama Paul, Walker Ashley E, Carter Gregory, Sasner Michael, Territo Paul R, Howell Gareth R

Synaptic proteins that aggregate and degrade slower with aging accumulate in microglia.

随着年龄增长,突触蛋白聚集和降解速度减慢,并在小胶质细胞中积累

Guldner Ian H, Wagner Viktoria P, Moran-Losada Patricia, Shi Sophia M, Chen Kelly, Meese Barbara T, Oh Hamilton, Le Guen Yann, Lu Nannan, Wong Pui Shuen, To Ning-Sum, Garceau Dylan, Guo Zimin, Luo Jian, Sasner Michael, Keller Andreas, Yang Andrew C, Cheung Tom, Wyss-Coray Tony