日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Reference-based chemical-genetic interaction profiling to elucidate small molecule mechanism of action in Mycobacterium tuberculosis

基于参考序列的化学-遗传相互作用分析阐明结核分枝杆菌中小分子的作用机制

Bond, Austin N; Orzechowski, Marek; Zhang, Shuting; Ben-Zion, Ishay; Lemmer, Allison; Garry, Nathaniel; Lee, Katie; Chen, Michael; Delano, Kayla; Gath, Emily; Golas, A Lorelei; Nietupski, Raymond; Fitzgerald, Michael; Ehrt, Sabine; Rubin, Eric J; Sassetti, Christopher M; Schnappinger, Dirk; Shoresh, Noam; Hunt, Diana K; Gomez, James E; Hung, Deborah T

Chemical genetic interactions elucidate pathways controlling tuberculosis antibiotic efficacy during infection.

化学遗传相互作用阐明了结核病感染期间控制抗生素疗效的途径

Oluoch Peter O, Koh Eun-Ik, Proulx Megan K, Reames Charlotte J, Papavinasasundaram Kadamba G, Murphy Kenan C, Zimmerman Matthew D, Dartois Véronique, Sassetti Christopher M

Impaired fatty acid import or catabolism in macrophages restricts intracellular growth of Mycobacterium tuberculosis

巨噬细胞内脂肪酸摄取或分解代谢受损会限制结核分枝杆菌的细胞内生长

Simwela, Nelson V; Jaecklein, Eleni; Sassetti, Christopher M; Russell, David G

Cross-species blood transcriptional correlates of BCG-mediated protection against tuberculosis include innate and adaptive immune processes

卡介苗介导的抗结核保护作用的跨物种血液转录相关性包括先天性和适应性免疫过程。

Bridges, Kate; Awany, Denis; Gela, Anele; Mwambene, Temwa-Dango; Kurtz, Sherry L; Baker, Richard E; Elkins, Karen L; Sassetti, Christopher M; Scriba, Thomas J; Lauffenburger, Douglas A

Frequently arising ESX-1-associated phase variants influence Mycobacterium tuberculosis fitness in the presence of host and antibiotic pressures.

频繁出现的 ESX-1 相关相变异体影响结核分枝杆菌在宿主和抗生素压力下的适应性

Luna Michael J, Oluoch Peter O, Miao Jiazheng, Culviner Peter, Papavinasasundaram Kadamba, Jaecklein Eleni, Shell Scarlet S, Ioerger Thomas R, Fortune Sarah M, Farhat Maha R, Sassetti Christopher M

Cross-species transcriptomics translation reveals a role for the unfolded protein response in Mycobacterium tuberculosis infection

跨物种转录组学翻译揭示了未折叠蛋白反应在结核分枝杆菌感染中的作用

Pullen, Krista M; Finethy, Ryan; Ko, Seung-Hyun B; Reames, Charlotte J; Sassetti, Christopher M; Lauffenburger, Douglas A

BCG induced innate immune response heterogeneity and susceptibility to pediatric tuberculosis

卡介苗诱导的先天免疫反应异质性和儿童结核病易感性

Anterasian, Christine; Gela, Anele; Mwambene, Temwa-Dango; Shah, Javeed A; Ivie, Josh; Dill-McFarland, Kimberly A; Hanekom, Willem A; Kiritsy, Michael C; Sassetti, Christopher M; Musvosvi, Munyaradzi; Hatherill, Mark; Scriba, Thomas J; Hawn, Thomas R

The Mycobacterium tuberculosis Transposon Sequencing Database (MtbTnDB): A Large-Scale Guide to Genetic Conditional Essentiality

结核分枝杆菌转座子测序数据库(MtbTnDB):大规模遗传条件必需性指南

Jinich, Adrian; Zaveri, Anisha; DeJesus, Michael A; Spencer, Amanda; Almada-Monter, Ricardo; Flores-Bautista, Emanuel; Smith, Clare M; Sassetti, Christopher M; Rock, Jeremy M; Ehrt, Sabine; Schnappinger, Dirk; Ioerger, Thomas R; Rhee, Kyu Y

Mycobacterium tuberculosis virulence lipid PDIM inhibits autophagy in mice.

结核分枝杆菌毒力脂质PDIM抑制小鼠自噬

Mittal Ekansh, Prasad G V R Krishna, Upadhyay Sandeep, Sadadiwala Jully, Olive Andrew J, Yang Guozhe, Sassetti Christopher M, Philips Jennifer A

Genome-wide screen of Mycobacterium tuberculosis-infected macrophages revealed GID/CTLH complex-mediated modulation of bacterial growth.

对结核分枝杆菌感染的巨噬细胞进行全基因组筛选,发现 GID/CTLH 复合物介导了细菌生长的调节

Simwela Nelson V, Johnston Luana, Bitar Paulina Pavinski, Jaecklein Eleni, Altier Craig, Sassetti Christopher M, Russell David G