日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Discovery of Selective and Orally Bioavailable Heterobifunctional Degraders of Cyclin-Dependent Kinase 2

发现选择性且口服生物利用度高的细胞周期蛋白依赖性激酶2异双功能降解剂

Collier, Philip N; Zheng, Xiaozhang; Ford, Melissa; Weiss, Matthew; Chen, Dapeng; Li, Kunhua; Growney, Joseph D; Yang, Annan; Sathappa, Murugappan; Breitkopf, Susanne B; Enerson, Brad; Liang, Tong; Paul, Atanu; Sawant, Rupa; Su, Lijing; Aversa, Robert J; Howarth, Charles; Sharma, Kirti; Williams, Juliet; Kwiatkowski, Nicholas P

Identification of small molecule inhibitors of PPM1D using an integrated drug discovery platform.

利用综合药物发现平台鉴定PPM1D小分子抑制剂

Shaw Subrata, Jiang Wei, Rush Jason, Dumont Nancy, Kim John, Singh Ritu, Skepner Adam, Khodier Carol, Raffier Cerise, Murphy Zachary, Yan Ni, Schluter Cameron, Yu Xiao, Szuchnicki Mateusz, Sathappa Murugappan, Kahn Josephine, Sperling Adam S, Wagner Florence, McKinney David C, Gould Alexandra E, Garvie Colin W, Miller Peter G

Identification of Small Molecule Inhibitors of PPM1D Using a Novel Drug Discovery Platform

利用新型药物发现平台鉴定 PPM1D 小分子抑制剂

Wei Jiang, Subrata Shaw, Jason Rush, Nancy Dumont, John Kim, Ritu Singh, Adam Skepner, Carol Khodier, Cerise Raffier, Ni Yan, Cameron Schluter, Xiao Yu, Mateusz Szuchnicki, Murugappan Sathappa, Josephine Kahn, Adam S Sperling, David C McKinney, Alexandra E Gould, Colin W Garvie, Peter G Miller

Molecular interaction of metastasis suppressor genes and tumor microenvironment in breast cancer

乳腺癌转移抑制基因与肿瘤微环境的分子相互作用

Supuramanian, Sathammai Sathappa; Dsa, Sid; Harihar, Sitaram

Allosteric inhibition of PPM1D serine/threonine phosphatase via an altered conformational state

通过改变构象状态对 PPM1D 丝氨酸/苏氨酸磷酸酶进行变构抑制

Peter G Miller #, Murugappan Sathappa #, Jamie A Moroco #, Wei Jiang, Yue Qian, Sumaiya Iqbal, Qi Guo, Andrew O Giacomelli, Subrata Shaw, Camille Vernier, Besnik Bajrami, Xiaoping Yang, Cerise Raffier, Adam S Sperling, Christopher J Gibson, Josephine Kahn, Cyrus Jin, Matthew Ranaghan, Alisha Caliman

Defining the landscape of ATP-competitive inhibitor resistance residues in protein kinases

定义蛋白激酶中 ATP 竞争性抑制剂抗性残基的概况

N S Persky, D Hernandez #, M Do Carmo #, L Brenan #, O Cohen, S Kitajima, U Nayar, A Walker, S Pantel, Y Lee, J Cordova, M Sathappa, C Zhu, T K Hayes, P Ram, P Pancholi, T S Mikkelsen, D A Barbie, X Yang, R Haq, F Piccioni, D E Root, C M Johannessen

Multimodal small-molecule screening for human prion protein binders

人类朊病毒蛋白结合剂的多模式小分子筛选

Andrew G Reidenbach, Michael F Mesleh, Dominick Casalena, Sonia M Vallabh, Jayme L Dahlin, Alison J Leed, Alix I Chan, Dmitry L Usanov, Jenna B Yehl, Christopher T Lemke, Arthur J Campbell, Rishi N Shah, Om K Shrestha, Joshua R Sacher, Victor L Rangel, Jamie A Moroco, Murugappan Sathappa, Maria Cris

The mitochondria-targeted peptide SS-31 binds lipid bilayers and modulates surface electrostatics as a key component of its mechanism of action

靶向线粒体的肽SS-31通过结合脂质双层并调节表面静电作用,发挥其关键作用机制。

Mitchell, Wayne; Ng, Emily A; Tamucci, Jeffrey D; Boyd, Kevin J; Sathappa, Murugappan; Coscia, Adrian; Pan, Meixia; Han, Xianlin; Eddy, Nicholas A; May, Eric R; Szeto, Hazel H; Alder, Nathan N

Ionization Properties of Phospholipids Determined by Zeta Potential Measurements

通过 Zeta 电位测量确定磷脂的电离特性

Murugappan Sathappa, Nathan N Alder