日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Nucleophile-triggered prodrug release from polymer hydrogels

亲核试剂触发聚合物水凝胶中前药的释放

Klemm, Benjamin; Tavasso, Magherita; Piergentili, Irene; Satijn, Max; Brevé, Tobias G; Boukany, Pouyan E; Eelkema, Rienk

Rational selection of the monoclonal α-synuclein antibody amlenetug (Lu AF82422) for the treatment of α-synucleinopathies.

合理选择单克隆α-突触核蛋白抗体amlenetug(Lu AF82422)用于治疗α-突触核蛋白病

Kallunki Pekka, Sotty Florence, Willén Katarina, Lubas Michal, David Laurent, Ambjørn Malene, Bergström Ann-Louise, Buur Louise, Malik Ibrahim, Nyegaard Steffen, Eriksen Thomas Thiilmark, Krogh Berit O, Stavenhagen Jeffrey B, Andersen Kathrine J, Pedersen Lars Ø, Cholak Ersoy, van den Brink Edward N, Rademaker Rik, Vink Tom, Satijn David, Parren Paul W H I, Christensen Søren, Olsen Line R, Søderberg Josefine N, Vergo Sandra, Jensen Allan, Egebjerg Jan, Wulff-Larsen Pernille Gry, Harndahl Mikkel N, Damlund Dina S M, Bjerregaard-Andersen Kaare, Fog Karina

A hexamerization-enhanced, Fc-silenced agonistic CD27 antibody amplifies T-cell effector functions as single agent and in combination with PD-1 blockade

一种经六聚化增强、Fc沉默的激动性CD27抗体,可作为单药或与PD-1阻断剂联合使用,增强T细胞效应功能。

Işıl Altıntaş ,Kristina B Nürmberger ,Andrea Imle ,Anna-Lena Krause ,Marike M van Beuge ,Aras Toker ,Andreea Ioan-Facsinay ,Jordan Blum ,Alexander Muik ,Frank J Beurskens ,Rob N de Jong ,David P E Satijn ,Friederike Gieseke ,Bart-Jan de Kreuk ,Maarten van der Kroef ,Sina Fellermeier-Kopf ,Tahamtan Ahmadi ,Özlem Türeci ,Esther C W Breij ,Uğur Şahin

Preclinical Characterization and Phase I Trial Results of a Bispecific Antibody Targeting PD-L1 and 4-1BB (GEN1046) in Patients with Advanced Refractory Solid Tumors

针对晚期难治性实体瘤患者的靶向PD-L1和4-1BB的双特异性抗体(GEN1046)的临床前特征和I期试验结果

Alexander Muik,Elena Garralda,Isil Altintas,Friederike Gieseke,Ravit Geva,Eytan Ben-Ami,Corinne Maurice-Dror,Emiliano Calvo,Patricia M LoRusso,Guzman Alonso,Maria E Rodriguez-Ruiz,Kristina B Schoedel,Jordan M Blum,Bianca Sänger,Theodora W Salcedo,Saskia M Burm,Eliana Stanganello,Dennis Verzijl,Fulvia Vascotto,Angelica Sette,Juliane Quinkhardt,Theo S Plantinga,Aras Toker,Edward N van den Brink,Mark Fereshteh,Mustafa Diken,David Satijn,Sebastian Kreiter,Esther C W Breij,Gaurav Bajaj,Eleni Lagkadinou,Kate Sasser,Özlem Türeci,Ulf Forssmann,Tahamtan Ahmadi,Uğur Şahin #,Maria Jure-Kunkel #,Ignacio Melero #

DuoBody-CD40x4-1BB induces dendritic-cell maturation and enhances T-cell activation through conditional CD40 and 4-1BB agonist activity

DuoBody-CD40x4-1BB 通过条件性 CD40 和 4-1BB 激动剂活性诱导树突状细胞成熟并增强 T 细胞活化。

Alexander Muik ,Homer C Adams 3rd ,Friederike Gieseke ,Isil Altintas ,Kristina B Schoedel ,Jordan M Blum ,Bianca Sänger ,Saskia M Burm ,Eliana Stanganello ,Dennis Verzijl ,Vanessa M Spires ,Fulvia Vascotto ,Aras Toker ,Juliane Quinkhardt ,Mark Fereshteh ,Mustafa Diken ,David P E Satijn ,Sebastian Kreiter ,Tahamtan Ahmadi ,Esther C W Breij ,Özlem Türeci ,Kate Sasser ,Ugur Sahin ,Maria Jure-Kunkel

Mechanistic and pharmacodynamic studies of DuoBody-CD3x5T4 in preclinical tumor models

DuoBody-CD3x5T4 在临床前肿瘤模型中的机制和药效学研究

Kristel Kemper ,Ellis Gielen ,Peter Boross ,Mischa Houtkamp ,Theo S Plantinga ,Stefanie Ah de Poot ,Saskia M Burm ,Maarten L Janmaat ,Louise A Koopman ,Edward N van den Brink ,Rik Rademaker ,Dennis Verzijl ,Patrick J Engelberts ,David Satijn ,A Kate Sasser ,Esther Cw Breij

An Fc-inert PD-L1×4-1BB bispecific antibody mediates potent anti-tumor immunity in mice by combining checkpoint inhibition and conditional 4-1BB co-stimulation

Fc 惰性 PD-L1×4-1BB 双特异性抗体通过结合检查点抑制和条件性 4-1BB 共刺激在小鼠中介导强大的抗肿瘤免疫

Alexander Muik, Isil Altintas, Friederike Gieseke, Kristina B Schoedel, Saskia M Burm, Aras Toker, Theodora W Salcedo, Dennis Verzijl, David Eisel, Christian Grunwitz, Lena M Kranz, Mathias Vormehr, David P E Satijn, Mustafa Diken, Sebastian Kreiter, Kate Sasser, Tahamtan Ahmadi, Özlem Türeci, Esthe

IL-8 as antibody therapeutic target in inflammatory diseases: reduction of clinical activity in palmoplantar pustulosis

IL-8 作为炎症性疾病的抗体治疗靶点:降低掌跖脓疱病的临床活动性

Lone Skov, Frank J Beurskens, Claus O C Zachariae, Sakari Reitamo, Jessica Teeling, David Satijn, Kim M Knudsen, Elmieke P J Boot, Debra Hudson, Ole Baadsgaard, Paul W H I Parren, Jan G J van de Winkel

Galectin-1 is essential in tumor angiogenesis and is a target for antiangiogenesis therapy

半乳糖凝集素-1在肿瘤血管生成中至关重要,是抗血管生成治疗的靶点

Victor L J L Thijssen, Ruben Postel, Ricardo J M G E Brandwijk, Ruud P M Dings, Irina Nesmelova, Sietske Satijn, Nicole Verhofstad, Yusaku Nakabeppu, Linda G Baum, Jeroen Bakkers, Kevin H Mayo, Françoise Poirier, Arjan W Griffioen

Coexpression of BMI-1 and EZH2 polycomb group genes in Reed-Sternberg cells of Hodgkin's disease

霍奇金病里德-斯滕伯格细胞中BMI-1和EZH2多梳基因的共表达

Raaphorst, F M; van Kemenade, F J; Blokzijl, T; Fieret, E; Hamer, K M; Satijn, D P; Otte, A P; Meijer, C J