Complete inhibition of ABCB1 and ABCG2 at the blood-brain barrier by co-infusion of erlotinib and tariquidar to improve brain delivery of the model ABCB1/ABCG2 substrate [11C]erlotinib
通过同时输注厄洛替尼和他利奎达,完全抑制血脑屏障上的 ABCB1 和 ABCG2,从而改善模型 ABCB1/ABCG2 底物 [11C] 厄洛替尼的脑内输送
期刊:Journal of Cerebral Blood Flow and Metabolism
影响因子:4.9
doi:10.1177/0271678X20965500
Nicolas Tournier, Sebastien Goutal, Severin Mairinger, Irene Hernández-Lozano, Thomas Filip, Michael Sauberer, Fabien Caillé, Louise Breuil, Johann Stanek, Anna F Freeman, Gaia Novarino, Charles Truillet, Thomas Wanek, Oliver Langer