日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Design of potent and selective hybrid inhibitors of the mitotic kinase Nek2: structure-activity relationship, structural biology, and cellular activity

有丝分裂激酶 Nek2 的强效和选择性混合抑制剂的设计:结构-活性关系、结构生物学和细胞活性

Paolo Innocenti, Kwai-Ming J Cheung, Savade Solanki, Corine Mas-Droux, Fiona Rowan, Sharon Yeoh, Kathy Boxall, Maura Westlake, Lisa Pickard, Tara Hardy, Joanne E Baxter, G Wynne Aherne, Richard Bayliss, Andrew M Fry, Swen Hoelder

Aminopyrazine inhibitors binding to an unusual inactive conformation of the mitotic kinase Nek2: SAR and structural characterization

氨基吡嗪抑制剂与有丝分裂激酶 Nek2 的异常非活性构象结合:SAR 和结构表征

Daniel K Whelligan, Savade Solanki, Dawn Taylor, Douglas W Thomson, Kwai-Ming J Cheung, Kathy Boxall, Corine Mas-Droux, Caterina Barillari, Samantha Burns, Charles G Grummitt, Ian Collins, Rob L M van Montfort, G Wynne Aherne, Richard Bayliss, Swen Hoelder