日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Reduction of RAD23A extends lifespan and mitigates pathology in a mouse model of TDP-43 proteinopathy.

RAD23A 的减少可延长 TDP-43 蛋白病小鼠模型的寿命并减轻病理。

Guo Xueshui, Prajapati Ravindra Singh, Chun Jiyeon, Byun Insuk, Gebis Kamil K, Wang Yi-Zhi, Ling Karen, Dalton Casey, Blair Jeff A, Hamidianjahromi Anahid, Bachmann Gemma, Rigo Frank, Jafar-Nejad Paymaan, Savas Jeffrey N, Lee Min Jae, Sreedharan Jemeen, Kalb Robert G

Soluble α2δ-1, altered in disease CSF, modulates network homeostasis and rescues deficits in a neuropsychiatric mouse model

疾病脑脊液中可溶性α2δ-1的改变,能够调节网络稳态并挽救神经精神疾病小鼠模型中的缺陷。

Dos Santos, Marc; Forrest, Marc P; Bomba-Warczak, Ewa; Dey, Soumil; Parnell, Euan; Christiansen, Jessica M; Edassery, Seby L; Yang, Kun; Hayes, Lindsay N; Coughlin, Jennifer M; Eckman, Blair L; Lammert, Catherine R; Martin-de-Saavedra, M Dolores; Barbolina, Maria V; Martina, Marco; Sawa, Akira; Savas, Jeffrey N; Penzes, Peter

Levetiracetam prevents Aβ production through SV2a-dependent modulation of APP processing in Alzheimer's disease models

左乙拉西坦通过SV2a依赖性调节APP加工来抑制阿尔茨海默病模型中Aβ的产生。

Rao, Nalini R; Santiago-Marrero, Ivan; DeGulis, Olivia; Nomura, Toshihiro; Goyal, Kritika; Lee, SeungEun; Hark, Timothy J; Dynes, Justin C; Dexter, Emily X; Dulewicz, Maciej; Ge, Junyue; Upadhyay, Arun; Fornasiero, Eugenio F; Vassar, Robert; Hanrieder, Jörg; Contractor, Anis; Savas, Jeffrey N

N-acetyl-l-leucine lowers α-synuclein levels and improves synaptic function in Parkinson's disease models.

N-乙酰-L-亮氨酸可降低α-突触核蛋白水平,并改善帕金森病模型中的突触功能。

Song Pingping, Chen Chuyu, Franchini Rossella, Duong Bryan, Wang Yi-Zhi, Coukos Robert, Xie Zhong, Savas Jeffrey N, Zhou Yueqin, Bertoldi Mariarita, Surmeier D James, Parisiadou Loukia, Krainc Dimitri

Response dynamics of discrete subiculum→retrosplenial cortex projections underlying trace fear conditioning.

离散的下托→后扣带皮层投射的反应动力学,是痕迹恐惧条件反射的基础。

Bassett Thomas E, Wang Yi-Zhi, Wood Elizabeth M, Zhang Hui, Petrovic Zorica, Prifti Vivien, Jovasevic Vladimir, Yamawaki Naoki, Ren Lynn, Khalatyan Natalia, Grayson Viktoriya, Savas Jeffrey N, Radulovic Jelena, Cicvaric Ana

In Vivo Screen of Parkinson's Disease GWAS Risk Genes Identifies ARIH2 as a Novel Regulator of α-Synuclein Toxicity in Dopaminergic Neurons

帕金森病全基因组关联研究风险基因的体内筛选发现ARIH2是多巴胺能神经元中α-突触核蛋白毒性的新型调节因子

Armakola, Maria; Wilen, Anika P; Bustos, Bernabe I; Song, Pingping; Wang, Yi-Zhi; Thomas, Adeyemi K; Belur, Nandkishore R; Mazzulli, Joseph R; Savas, Jeffrey N; Kalb, Robert G; Krainc, Dimitri

Ubiquitin Proteasome System Components, RAD23A and USP13, Modulate TDP-43 Solubility and Neuronal Toxicity.

泛素蛋白酶体系统成分 RAD23A 和 USP13 调节 TDP-43 溶解度和神经元毒性。

Dalton Casey, Mojsilovic-Petrovic Jelena, Safren Nathaniel, Snoznik Carley, Gebis Kamil K, Wang Yi-Zhi, Sutter Alexandra B, Lamitina Todd, Savas Jeffrey N, Kalb Robert G

A pathogenic AMPA receptor gating mutation disrupts synapse-mitochondrion axis and stalls synapse maturation

致病性AMPA受体门控突变会破坏突触-线粒体轴并阻碍突触成熟。

Xu, Jian; Wang, Yi-Zhi; Nomura, Toshihiro; Van, Han; Zhu, Yiwen; Castillon, Charlotte C M; Marshall, John J; Armstrong, John N; Zhu, Yongling; Savas, Jeffrey N; Contractor, Anis

DELTA: a method for brain-wide measurement of synaptic protein turnover reveals localized plasticity during learning.

DELTA:一种用于测量全脑突触蛋白周转率的方法,揭示了学习过程中的局部可塑性

Mohar Boaz, Michel Gabriela, Wang Yi-Zhi, Hernandez Veronica, Grimm Jonathan B, Park Jin-Yong, Patel Ronak, Clarke Morgan, Brown Timothy A, Bergmann Cornelius, Gebis Kamil K, Wilen Anika P, Liu Bian, Johnson Richard, Graves Austin, Tchumatchenko Tatjana, Savas Jeffrey N, Fornasiero Eugenio F, Huganir Richard L, Tillberg Paul W, Lavis Luke D, Svoboda Karel, Spruston Nelson

The UNC5C T835M mutation associated with Alzheimer's disease leads to neurodegeneration involving oxidative stress and hippocampal atrophy in aged mice.

与阿尔茨海默病相关的 UNC5C T835M 突变会导致老年小鼠出现涉及氧化应激和海马萎缩的神经退行性变

Karunakaran Devi Krishna Priya, Ley Makenna, Guo Joanna, Khatri Ammaarah, Sadleir Katherine, Popovic Jelena, Upadhyay Arun Kumar, Savas Jeffrey, Procissi Daniele, Atwal Jasvinder, Vassar Robert