日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Targeting immune cells in the aged brain reveals that engineered cytokine IL-10 enhances neurogenesis and improves cognition.

针对老年大脑中的免疫细胞的研究表明,工程细胞因子 IL-10 可以增强神经发生并改善认知能力。

Navarro Negredo Paloma, You Justin, Hauptschein Max, Schroer Adam B, Richard Daniel J, Abhiraman Gita C, Tsai Andy P, Sun Eric D, Notarangelo Giulia, Ramirez-Matias Julliana, Zhou Olivia Y, Buckley Matthew T, Malacon Karen E, Xu Lucy, Sucharov Juliana, Ramirez Lopez Eduardo, Picton Lora, Wyss-Coray Tony, Saxton Robert A, Fernandes Ricardo A, Villeda Saul A, Garcia K Christopher, Brunet Anne

Structure of the interleukin-5 receptor complex exemplifies the organizing principle of common beta cytokine signaling.

白细胞介素-5受体复合物的结构体现了β细胞因子信号传导的组织原则

Caveney Nathanael A, Rodriguez Grayson E, Pollmann Christoph, Meyer Thomas, Borowska Marta T, Wilson Steven C, Wang Nan, Xiang Xinyu, Householder Karsten D, Tao Pingdong, Su Leon L, Saxton Robert A, Piehler Jacob, Garcia K Christopher

Emerging principles of cytokine pharmacology and therapeutics

细胞因子药理学和治疗学的新兴原理

Saxton, Robert A; Glassman, Caleb R; Garcia, K Christopher

Structural basis of Janus kinase trans-activation

Janus激酶反式激活的结构基础

Caveney, Nathanael A; Saxton, Robert A; Waghray, Deepa; Glassman, Caleb R; Tsutsumi, Naotaka; Hubbard, Stevan R; Garcia, K Christopher

Structure of a Janus kinase cytokine receptor complex reveals the basis for dimeric activation

Janus激酶细胞因子受体复合物的结构揭示了二聚体激活的基础

Glassman, Caleb R; Tsutsumi, Naotaka; Saxton, Robert A; Lupardus, Patrick J; Jude, Kevin M; Garcia, K Christopher

Cryo-EM structure of the IL-10 receptor complex provides a blueprint for ligand engineering

IL-10受体复合物的冷冻电镜结构为配体工程提供了蓝图。

Saxton, Robert A; Garcia, K Christopher

Structure-based decoupling of the pro- and anti-inflammatory functions of interleukin-10

基于结构的白细胞介素-10促炎和抗炎功能的解耦

Saxton, Robert A; Tsutsumi, Naotaka; Su, Leon L; Abhiraman, Gita C; Mohan, Kritika; Henneberg, Lukas T; Aduri, Nanda G; Gati, Cornelius; Garcia, K Christopher

SAMTOR is an S-adenosylmethionine sensor for the mTORC1 pathway

SAMTOR是mTORC1通路中的S-腺苷甲硫氨酸传感器。

Gu, Xin; Orozco, Jose M; Saxton, Robert A; Condon, Kendall J; Liu, Grace Y; Krawczyk, Patrycja A; Scaria, Sonia M; Harper, J Wade; Gygi, Steven P; Sabatini, David M

mTOR Signaling in Growth, Metabolism, and Disease

mTOR信号通路在生长、代谢和疾病中的作用

Saxton, Robert A; Sabatini, David M

The apo-structure of the leucine sensor Sestrin2 is still elusive

亮氨酸传感器Sestrin2的无配体结构仍然难以捉摸。

Saxton, Robert A; Knockenhauer, Kevin E; Schwartz, Thomas U; Sabatini, David M