日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Assay Identifies Nilotinib as an Inhibitor of Inflammation in Acute Myeloid Leukemia

基质辅助激光解吸/电离飞行时间分析证实尼洛替尼是急性髓系白血病炎症抑制剂

José Luis Marín-Rubio, Rachel E Peltier-Heap, Maria Emilia Dueñas, Tiaan Heunis, Abeer Dannoura, Joseph Inns, Jonathan Scott, A John Simpson, Helen J Blair, Olaf Heidenreich, James M Allan, Jessica E Watt, Mathew P Martin, Barbara Saxty, Matthias Trost

Novel Macrocyclic Antagonists of the CGRP Receptor Part 2: Stereochemical Inversion Induces an Unprecedented Binding Mode

CGRP受体的新型大环拮抗剂(第二部分):立体化学反转诱导了一种前所未有的结合模式

Southall, Stacey M; Banerjee, Joydeep; Brown, Jason; Butkovic, Kristina; Cansfield, Andrew D; Cansfield, Julie E; Congreve, Miles S; Cseke, Gabriella; Deflorian, Francesca; Hunjadi, Martina Petrovic; Hutinec, Antun; Inturi, Trinadh Kumar; Rupcic, Renata; Saxty, Gordon; Watson, Stephen P

ULK1 inhibition promotes oxidative stress-induced differentiation and sensitizes leukemic stem cells to targeted therapy

ULK1抑制促进氧化应激诱导的分化,并使白血病干细胞对靶向治疗更加敏感

Angela Ianniciello ,Martha M Zarou ,Kevin M Rattigan ,Mary Scott ,Amy Dawson ,Karen Dunn ,Zuzana Brabcova ,Eric R Kalkman ,Colin Nixon ,Alison M Michie ,Mhairi Copland ,David Vetrie ,Martin Ambler ,Barbara Saxty ,G Vignir Helgason

Allosteric activation of MALT1 by its ubiquitin-binding Ig3 domain

MALT1 通过其泛素结合 Ig3 结构域进行变构激活

Rebekka Schairer, Gareth Hall, Ming Zhang, Richard Cowan, Roberta Baravalle, Frederick W Muskett, Peter J Coombs, Chido Mpamhanga, Lisa R Hale, Barbara Saxty, Justyna Iwaszkiewicz, Chantal Décaillet, Mai Perroud, Mark D Carr, Margot Thome

Pharmacological inhibition of ULK1 kinase blocks mammalian target of rapamycin (mTOR)-dependent autophagy

ULK1 激酶的药理抑制可阻断哺乳动物雷帕霉素靶蛋白 (mTOR) 依赖性自噬

Katy J Petherick, Owen J L Conway, Chido Mpamhanga, Simon A Osborne, Ahmad Kamal, Barbara Saxty, Ian G Ganley

Pharmacological inhibition of ULK1 kinase blocks mammalian target of rapamycin (mTOR)-dependent autophagy

ULK1激酶的药理学抑制可阻断哺乳动物雷帕霉素靶蛋白(mTOR)依赖性自噬

Petherick, Katy J; Conway, Owen J L; Mpamhanga, Chido; Osborne, Simon A; Kamal, Ahmad; Saxty, Barbara; Ganley, Ian G

Substituted aminopyrimidine protein kinase B (PknB) inhibitors show activity against Mycobacterium tuberculosis

取代氨基嘧啶蛋白激酶B (PknB) 抑制剂对结核分枝杆菌显示出活性

Chapman, Timothy M; Bouloc, Nathalie; Buxton, Roger S; Chugh, Jasveen; Lougheed, Kathryn E A; Osborne, Simon A; Saxty, Barbara; Smerdon, Stephen J; Taylor, Debra L; Whalley, David

The purification of a cysteine-dependent NAD+ glycohydrolase activity from bovine erythrocytes and evidence that it exhibits a novel ADP-ribosyltransferase activity

从牛红细胞中纯化出一种半胱氨酸依赖性NAD+糖苷水解酶活性,并证实其具有新型ADP-核糖基转移酶活性。

Saxty, B A; van Heyningen, S