日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

14-3-3ζ interacts with DNA-binding domain of FOXO3a and competitively dissociates DNA by dual-motif tethering

14-3-3ζ 与 FOXO3a 的 DNA 结合域相互作用，并通过双基序束缚竞争性地解离 DNA。

期刊:Nature Communications
影响因子:15.7
doi:10.1038/s41467-026-69203-8
Enomoto, Shota; Kuwayama, Tomoya; Nakatsuka, Shoichi; Yokogawa, Mariko; Kawatsu, Kosaku; Nakamura, Risa; Kimura, Tomomi; Tanabe, Mikio; Senda, Toshiya; Saito, Jun; Saya, Hideyuki; Osawa, Masanori
FOXO3
发表日期：2026
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Rapid Drug Sensitivity Profiling via a Novel High-Success-Rate Culture Method for Patient-Derived Pancreatic Cancer: An Exploratory Preclinical Platform for Advancing Clinical Applications and Drug Development

利用新型高成功率培养方法对患者来源的胰腺癌细胞进行快速药物敏感性分析：一个用于推进临床应用和药物开发的探索性临床前平台

期刊:Cells
影响因子:5.2
doi:10.3390/cells15040313
Kato, Yu; Yamamoto, Naoki; Uchida, Yuichiro; Hiramatsu, Noriko; Ozeki, Takato; Minobe, Yukari; Hasegawa, Yukika; Kawabe, Sho; Yabuuchi, Hikaru; Yamada, Seiji; Hata, Yuko; Sugihara, Eiji; Takimoto, Tetsuya; Saito, Kuniaki; Takahara, Takeshi; Suda, Koichi; Nagano, Osamu; Saya, Hideyuki
胰腺癌
肿瘤
肿瘤免疫
细胞生物学
发表日期：2026
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Genomic Profiling in Localized Prostate Cancer: Associations With Biochemical Recurrence and Response to Salvage Radiotherapy

局限性前列腺癌的基因组分析：与生化复发和挽救性放疗反应的关联

期刊:Cancer Science
影响因子:4.3
doi:10.1111/cas.70367
Zennami, Kenji; Takimoto, Tetsuya; Nukaya, Takuhisa; Sumitomo, Makoto; Takeda, Mayu; Sugihara, Eiji; Saya, Hideyuki; Shiroki, Ryoichi
肿瘤
肿瘤免疫
前列腺癌
发表日期：2026
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Drug Repurposing Screen Identifies Pimozide as a ROS-Inducing Therapy With Anti-Tumor Efficacy in HNSCC PDX Models

药物再利用筛选发现匹莫齐特是一种ROS诱导疗法，在头颈部鳞状细胞癌PDX模型中具有抗肿瘤疗效

期刊:Cancer Science
影响因子:4.3
doi:10.1111/cas.70253
Okazaki, Shogo; Nakamura, Shintaro; Soma, Tomoya; Yoshikawa, Momoko; Asoda, Seiji; Nakajima, Yurika; Tsuchihashi, Kenji; Ohmura, Mitsuyo; Goitsuka, Ryo; Imai, Kenichi; Saya, Hideyuki; Nagano, Osamu; Ozawa, Hiroyuki
细胞生物学
肿瘤
肿瘤免疫
发表日期：2026
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Depleting HIF‑1α attenuates the progression of osteosarcoma, but tumorigenicity is sustained through HIF‑independent pathways

抑制HIF-1α可减缓骨肉瘤的进展，但肿瘤发生仍可通过非HIF依赖性途径维持。

期刊:Oncology Reports
影响因子:3.9
doi:10.3892/or.2026.9099
Kunishima, Ayaka; Shimizu, Takatsune; Takimoto, Tetsuya; Sagara, Atsunobu; Nobusue, Hiroyuki; Hasuwa, Hidetoshi; Hasegawa, Shinya; Tamaoki, Yuka; Miyake, Hitomi; Fukuchi, Yumi; Saya, Hideyuki; Muto, Akihiro
肿瘤
骨肉瘤
肿瘤免疫
发表日期：2026
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Establishment of a Large-Scale PDX Library of Head and Neck Cancers for Functional Precision Oncology

建立用于功能性精准肿瘤学的大规模头颈癌PDX模型库

期刊:Cancer Medicine
影响因子:3.1
doi:10.1002/cam4.71521
Yanagi, Hisano; Kuki, Tomoki; Takimoto, Tetsuya; Takabayashi, Miki; Yamada, Seiji; Yagi, Chikako; Kiryu, Yoshitake; Kurimoto, Maki; Ishikawa, Miho; Yoshida, Arisa; Mizutani, Yasuyoshi; Enomoto, Atsushi; Suzuki, Motoshi; Kawada, Kenji; Kato, Hisayuki; Tateya, Ichiro; Saya, Hideyuki; Watanabe, Takashi
肿瘤
肿瘤免疫
头颈癌
发表日期：2026
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Flopropione, a Cysteine Conjugate β-Lyase 1 Inhibitor, for Prevention of Cisplatin-Induced Nephrotoxicity: Protocol for a Randomized, Open-Label, Proof-of-Concept Phase 1 and 2a Trial

氟丙酮（一种半胱氨酸结合物β-裂解酶1抑制剂）用于预防顺铂引起的肾毒性：一项随机、开放标签、概念验证性1期和2a期试验方案

期刊:JMIR Research Protocols
影响因子:1.5
doi:10.2196/87907
Koseki, Takenao; Kondo, Masashi; Fujigaki, Hidetsugu; Kikuchi, Kayoko; Oya, Yuko; Kato, Hiroshi; Mizuno, Tomohiro; Tsuboi, Naotake; Kawada, Kenji; Goto, Yasuhiro; Hashimoto, Naozumi; Imaizumi, Kazuyoshi; Kada, Akiko; Yabuuchi, Hikaru; Saito, Kuniaki; Saya, Hideyuki
毒理研究
发表日期：2026
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Benzaldehyde suppresses epithelial-mesenchymal plasticity and overcomes treatment resistance in cancer by targeting the interaction of 14-3-3ζ with H3S28ph

苯甲醛通过靶向14-3-3ζ与H3S28ph的相互作用，抑制上皮-间质可塑性并克服癌症治疗耐药性。

期刊:British Journal of Cancer
影响因子:6.8
doi:10.1038/s41416-025-03006-4
Saito, Jun; Onishi, Nobuyuki; Yamasaki, Juntaro; Koike, Naoyoshi; Hata, Yukie; Kimura, Kiyomi; Otsuki, Yuji; Nobusue, Hiroyuki; Sampetrean, Oltea; Shimizu, Takatsune; Okazaki, Shogo; Sugihara, Eiji; Saya, Hideyuki
肿瘤
肿瘤免疫
治疗耐药
发表日期：2025
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Significance of homologous recombinant deficiency as a biomarker for drug sensitivity in colorectal cancer.

同源重组缺陷作为结直肠癌药物敏感性生物标志物的意义

期刊:British Journal of Cancer
影响因子:6.8
doi:10.1038/s41416-025-02950-5
Kato Yujin, Seishima Ryo, Hattori Kaoru, Kato Hirochika, Ishida Hiroki, Shigeta Kohei, Okabayashi Koji, Sugihara Eiji, Takimoto Tetsuya, Nakamura Kohei, Nishihara Hiroshi, Saya Hideyuki, Kitagawa Yuko
肿瘤
肠癌
发表日期：2025
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Targeting distinct amino acid metabolic vulnerabilities in IDH-mutant and IDH-wildtype gliomas

针对IDH突变型和IDH野生型胶质瘤中不同的氨基酸代谢脆弱性进行治疗

期刊:Acta Neuropathologica Communications
影响因子:5.7
doi:10.1186/s40478-025-02193-8
Ohba, Shigeo; Hirayama, Akiyoshi; Teranishi, Takao; Hitachi, Keisuke; Yamaguchi, Hisateru; Murayama, Kazuhiro; Natsumeda, Manabu; Tateishi, Kensuke; Tsuchida, Kunihiro; Wakimoto, Hiroaki; Saya, Hideyuki; Pieper, Russell; Hirose, Yuichi
氨基酸代谢
胶质瘤
代谢
发表日期：2025
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