日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Combining a rhesus cytomegalovirus/SIV vaccine with neutralizing antibody to protect against SIV challenge in rhesus macaques

将恒河猴巨细胞病毒/SIV疫苗与中和抗体结合,以保护恒河猴免受SIV攻击

Coppola, Jessica; Parren, Mara; Bastidas, Raiza; Saye-Francisco, Karen; Malvin, Jacqueline; Jardine, Joseph G; Gilbride, Roxanne M; Ojha, Sohita; Feltham, Shana; Morrow, David; Barber-Axthelm, Aaron; Bochart, Rachele; Fast, Randy; Oswald, Kelli; Shoemaker, Rebecca; Lifson, Jeffrey D; Picker, Louis J; Burton, Dennis R; Hansen, Scott G

Engineering HIV antibodies with enhanced breadth and potency of neutralization through multistate affinity maturation

通过多态亲和力成熟工程改造HIV抗体,增强其中和广度和效力

Kędzior, Mateusz; Phulera, Swastik; Fernández-Quintero, Monica L; Loeffler, Johannes R; Joyce, Collin; Woehl, Jordan; Abbasi, Abdolrahim; Karimi, Maryam; Aslanabadi, Arash; Hojabri, Mahsa; Zareidoodeji, Roza; Atkinson, Ben; Burgos, Eduar Fernando Pinzon; Heredia, Alonso; Saye-Francisco, Karen; Tran, Quoc; Kim, Yoojin; Acosta-Puente, Fernando; Shahin, Lara; Zhou, Amelia; Altman, Pilar X; Felbinger, Nathaniel R; Pierce, Brian G; Sok, Devin; Seaman, Michael S; Burton, Dennis R; DeVico, Anthony L; Ward, Andrew B; Ozorowski, Gabriel; Sajadi, Mohammad M; Jardine, Joseph G

Synthetic development of a broadly neutralizing antibody against snake venom long-chain α-neurotoxins

合成开发一种针对蛇毒长链α-神经毒素的广谱中和抗体

Khalek, Irene S; Senji Laxme, R R; Nguyen, Yen Thi Kim; Khochare, Suyog; Patel, Rohit N; Woehl, Jordan; Smith, Jessica M; Saye-Francisco, Karen; Kim, Yoojin; Misson Mindrebo, Laetitia; Tran, Quoc; Kędzior, Mateusz; Boré, Evy; Limbo, Oliver; Verma, Megan; Stanfield, Robyn L; Menzies, Stefanie K; Ainsworth, Stuart; Harrison, Robert A; Burton, Dennis R; Sok, Devin; Wilson, Ian A; Casewell, Nicholas R; Sunagar, Kartik; Jardine, Joseph G

Immunization of cows with HIV envelope trimers generates broadly neutralizing antibodies to the V2-apex from the ultralong CDRH3 repertoire

用 HIV 包膜三聚体对奶牛进行免疫接种,可产生针对超长 CDRH3 库中的 V2-apex 的广泛中和抗体

Pilar X Altman, Gabriel Ozorowski, Robyn L Stanfield, Jeremy Haakenson, Michael Appel, Mara Parren, Wen-Hsin Lee, Huldah Sang, Jordan Woehl, Karen Saye-Francisco, Leigh M Sewall, Collin Joyce, Ge Song, Katelyn Porter, Elise Landais, Raiees Andrabi, Ian A Wilson, Andrew B Ward, Waithaka Mwangi, Vaugh

Immunization of cows with HIV envelope trimers generates broadly neutralizing antibodies to the V2-apex from the ultralong CDRH3 repertoire

用 HIV 包膜三聚体免疫奶牛,可产生针对超长 CDRH3 库中 V2 顶端的广谱中和抗体。

Altman, Pilar X; Ozorowski, Gabriel; Stanfield, Robyn L; Haakenson, Jeremy; Appel, Michael; Parren, Mara; Lee, Wen-Hsin; Sang, Huldah; Woehl, Jordan; Saye-Francisco, Karen; Joyce, Collin; Song, Ge; Porter, Katelyn; Landais, Elise; Andrabi, Raiees; Wilson, Ian A; Ward, Andrew B; Mwangi, Waithaka; Smider, Vaughn V; Burton, Dennis R; Sok, Devin

Rapid and Focused Maturation of a VRC01-Class HIV Broadly Neutralizing Antibody Lineage Involves Both Binding and Accommodation of the N276-Glycan

VRC01类HIV广谱中和抗体谱系的快速且集中的成熟涉及N276-糖基化的结合和容纳。

Jeffrey Umotoy ,Bernard S Bagaya ,Collin Joyce ,Torben Schiffner ,Sergey Menis ,Karen L Saye-Francisco ,Trevor Biddle ,Sanjay Mohan ,Thomas Vollbrecht ,Oleksander Kalyuzhniy ,Sharon Madzorera ,Dale Kitchin ,Bronwen Lambson ,Molati Nonyane ,William Kilembe ,William R Schief ,Dennis R Burton ,Ben Murrell ,Penny L Moore ,Bryan Briney ,Devin Sok ,Elise Landais

HIV-1 vaccine design through minimizing envelope metastability

通过最小化包膜亚稳态来设计 HIV-1 疫苗

Linling He, Sonu Kumar, Joel D Allen, Deli Huang, Xiaohe Lin, Colin J Mann, Karen L Saye-Francisco, Jeffrey Copps, Anita Sarkar, Gabrielle S Blizard, Gabriel Ozorowski, Devin Sok, Max Crispin, Andrew B Ward, David Nemazee, Dennis R Burton, Ian A Wilson, Jiang Zhu

Rapid elicitation of broadly neutralizing antibodies to HIV by immunization in cows

通过对奶牛进行免疫接种快速诱发艾滋病毒广泛中和抗体

Devin Sok, Khoa M Le, Melissa Vadnais, Karen L Saye-Francisco, Joseph G Jardine, Jonathan L Torres, Zachary T Berndsen, Leopold Kong, Robyn Stanfield, Jennifer Ruiz, Alejandra Ramos, Chi-Hui Liang, Patricia L Chen, Michael F Criscitiello, Waithaka Mwangi, Ian A Wilson, Andrew B Ward, Vaughn V Smider

Hidden Lineage Complexity of Glycan-Dependent HIV-1 Broadly Neutralizing Antibodies Uncovered by Digital Panning and Native-Like gp140 Trimer

通过数字淘选和类天然gp140三聚体揭示糖基依赖性HIV-1广谱中和抗体的隐藏谱系复杂性

He, Linling; Lin, Xiaohe; de Val, Natalia; Saye-Francisco, Karen L; Mann, Colin J; Augst, Ryan; Morris, Charles D; Azadnia, Parisa; Zhou, Bin; Sok, Devin; Ozorowski, Gabriel; Ward, Andrew B; Burton, Dennis R; Zhu, Jiang

Lipid interactions and angle of approach to the HIV-1 viral membrane of broadly neutralizing antibody 10E8: Insights for vaccine and therapeutic design

广谱中和抗体 10E8 与 HIV-1 病毒膜的脂质相互作用和接近角度:疫苗和治疗设计的见解

Adriana Irimia, Andreia M Serra, Anita Sarkar, Ronald Jacak, Oleksandr Kalyuzhniy, Devin Sok, Karen L Saye-Francisco, Torben Schiffner, Ryan Tingle, Michael Kubitz, Yumiko Adachi, Robyn L Stanfield, Marc C Deller, Dennis R Burton, William R Schief, Ian A Wilson