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Severe Consequences of SAC3/FIG4 Phosphatase Deficiency to Phosphoinositides in Patients with Charcot-Marie-Tooth Disease Type-4J

SAC3/FIG4磷酸酶缺乏对夏科-马里-图斯病4J型患者磷脂酰肌醇的严重影响

期刊:Molecular Neurobiology

影响因子:4.3

doi:10.1007/s12035-019-01693-8

Shisheva, Assia; Sbrissa, Diego; Hu, Bo; Li, Jun

发表日期：2019

文献求助收藏

Apilimod, a candidate anticancer therapeutic, arrests not only PtdIns(3,5)P2 but also PtdIns5P synthesis by PIKfyve and induces bafilomycin A1-reversible aberrant endomembrane dilation

Apilimod 是一种候选抗癌疗法，它不仅能抑制 PtdIns(3,5)P2 的合成，还能抑制 PIKfyve 介导的 PtdIns5P 的合成，并诱导巴弗洛霉素 A1 可逆的异常内膜扩张。

期刊:PLoS One

影响因子:2.6

doi:10.1371/journal.pone.0204532

Sbrissa, Diego; Naisan, Ghassan; Ikonomov, Ognian C; Shisheva, Assia

Active vacuolar H+ ATPase and functional cycle of Rab5 are required for the vacuolation defect triggered by PtdIns(3,5)P2 loss under PIKfyve or Vps34 deficiency

PIKfyve 或 Vps34 缺陷导致的 PtdIns(3,5)P2 丢失会引发空泡化缺陷，而活性液泡 H+ ATPase 和 Rab5 的功能循环是必需的。

期刊:American Journal of Physiology-Cell Physiology

影响因子:4.7

doi:10.1152/ajpcell.00104.2016

Compton, Lauren M; Ikonomov, Ognian C; Sbrissa, Diego; Garg, Puneet; Shisheva, Assia

Rab5

发表日期：2016

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Plentiful PtdIns5P from scanty PtdIns(3,5)P2 or from ample PtdIns? PIKfyve-dependent models: Evidence and speculation (response to: DOI 10.1002/bies.201300012)

丰富的 PtdIns5P 是由稀少的 PtdIns(3,5)P2 产生，还是由充足的 PtdIns 产生？PIKfyve 依赖模型：证据与推测（回应：DOI 10.1002/bies.201300012）

期刊:Bioessays

影响因子:2.7

doi:10.1002/bies.201400129

Shisheva, Assia; Sbrissa, Diego; Ikonomov, Ognian

发表日期：2015

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The PIKfyve-ArPIKfyve-Sac3 triad in human breast cancer: Functional link between elevated Sac3 phosphatase and enhanced proliferation of triple negative cell lines.

PIKfyve-ArPIKfyve-Sac3 三联体在人类乳腺癌中的作用：Sac3 磷酸酶升高与三阴性细胞系增殖增强之间的功能联系

期刊:Biochemical and Biophysical Research Communications

影响因子:2.2

doi:10.1016/j.bbrc.2013.09.080

Ikonomov Ognian C, Filios Catherine, Sbrissa Diego, Chen Xuequn, Shisheva Assia

Functional dissociation between PIKfyve-synthesized PtdIns5P and PtdIns(3,5)P2 by means of the PIKfyve inhibitor YM201636

利用PIKfyve抑制剂YM201636实现PIKfyve合成的PtdIns5P与PtdIns(3,5)P2之间的功能性分离

期刊:American Journal of Physiology-Cell Physiology

影响因子:4.7

doi:10.1152/ajpcell.00105.2012

Sbrissa, Diego; Ikonomov, Ognian C; Filios, Catherine; Delvecchio, Khortnal; Shisheva, Assia

发表日期：2012

文献求助收藏

ArPIKfyve-PIKfyve interaction and role in insulin-regulated GLUT4 translocation and glucose transport in 3T3-L1 adipocytes

ArPIKfyve-PIKfyve相互作用及其在3T3-L1脂肪细胞中胰岛素调节的GLUT4转位和葡萄糖转运中的作用

期刊:Experimental Cell Research

影响因子:3.5

doi:10.1016/j.yexcr.2007.03.024

Ikonomov, Ognian C; Sbrissa, Diego; Dondapati, Rajeswari; Shisheva, Assia

A mammalian ortholog of Saccharomyces cerevisiae Vac14 that associates with and up-regulates PIKfyve phosphoinositide 5-kinase activity

酿酒酵母Vac14的哺乳动物同源物，可与PIKfyve磷脂酰肌醇5-激酶结合并上调其活性。

期刊:Molecular and Cellular Biology

影响因子:2.7

doi:10.1128/MCB.24.23.10437-10447.2004

Sbrissa, Diego; Ikonomov, Ognian C; Strakova, Jana; Dondapati, Rajeswari; Mlak, Krzysztof; Deeb, Robert; Silver, Robert; Shisheva, Assia

信号转导

发表日期：2004

文献求助收藏

PIKfyve controls fluid phase endocytosis but not recycling/degradation of endocytosed receptors or sorting of procathepsin D by regulating multivesicular body morphogenesis

PIKfyve 通过调节多泡体形态发生来控制液相内吞作用，但不控制内吞受体的回收/降解或前体组织蛋白酶 D 的分选。

期刊:Molecular Biology of the Cell

影响因子:2.7

doi:10.1091/mbc.e03-04-0222

Ikonomov, Ognian C; Sbrissa, Diego; Foti, Michelangelo; Carpentier, Jean-Louis; Shisheva, Assia

信号转导

发表日期：2003

文献求助收藏

A Novel Interaction between Chemokine and Phosphoinositide Signaling in Metastatic Prostate Cancer

转移性前列腺癌中趋化因子与磷脂酰肌醇信号通路的新型相互作用

Severe Consequences of SAC3/FIG4 Phosphatase Deficiency to Phosphoinositides in Patients with Charcot-Marie-Tooth Disease Type-4J

SAC3/FIG4磷酸酶缺乏对夏科-马里-图斯病4J型患者磷脂酰肌醇的严重影响

Apilimod, a candidate anticancer therapeutic, arrests not only PtdIns(3,5)P2 but also PtdIns5P synthesis by PIKfyve and induces bafilomycin A1-reversible aberrant endomembrane dilation

Apilimod 是一种候选抗癌疗法，它不仅能抑制 PtdIns(3,5)P2 的合成，还能抑制 PIKfyve 介导的 PtdIns5P 的合成，并诱导巴弗洛霉素 A1 可逆的异常内膜扩张。

Active vacuolar H+ ATPase and functional cycle of Rab5 are required for the vacuolation defect triggered by PtdIns(3,5)P2 loss under PIKfyve or Vps34 deficiency

PIKfyve 或 Vps34 缺陷导致的 PtdIns(3,5)P2 丢失会引发空泡化缺陷，而活性液泡 H+ ATPase 和 Rab5 的功能循环是必需的。

Plentiful PtdIns5P from scanty PtdIns(3,5)P2 or from ample PtdIns? PIKfyve-dependent models: Evidence and speculation (response to: DOI 10.1002/bies.201300012)

丰富的 PtdIns5P 是由稀少的 PtdIns(3,5)P2 产生，还是由充足的 PtdIns 产生？PIKfyve 依赖模型：证据与推测（回应：DOI 10.1002/bies.201300012）

The PIKfyve-ArPIKfyve-Sac3 triad in human breast cancer: Functional link between elevated Sac3 phosphatase and enhanced proliferation of triple negative cell lines.

PIKfyve-ArPIKfyve-Sac3 三联体在人类乳腺癌中的作用：Sac3 磷酸酶升高与三阴性细胞系增殖增强之间的功能联系

Functional dissociation between PIKfyve-synthesized PtdIns5P and PtdIns(3,5)P2 by means of the PIKfyve inhibitor YM201636

利用PIKfyve抑制剂YM201636实现PIKfyve合成的PtdIns5P与PtdIns(3,5)P2之间的功能性分离

ArPIKfyve-PIKfyve interaction and role in insulin-regulated GLUT4 translocation and glucose transport in 3T3-L1 adipocytes

ArPIKfyve-PIKfyve相互作用及其在3T3-L1脂肪细胞中胰岛素调节的GLUT4转位和葡萄糖转运中的作用

A mammalian ortholog of Saccharomyces cerevisiae Vac14 that associates with and up-regulates PIKfyve phosphoinositide 5-kinase activity

酿酒酵母Vac14的哺乳动物同源物，可与PIKfyve磷脂酰肌醇5-激酶结合并上调其活性。

PIKfyve controls fluid phase endocytosis but not recycling/degradation of endocytosed receptors or sorting of procathepsin D by regulating multivesicular body morphogenesis

PIKfyve 通过调节多泡体形态发生来控制液相内吞作用，但不控制内吞受体的回收/降解或前体组织蛋白酶 D 的分选。