日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Drug repurposing in amyotrophic lateral sclerosis (ALS)

肌萎缩侧索硬化症(ALS)的药物再利用

Carroll, Emily; Scaber, Jakub; Huber, Kilian V M; Brennan, Paul E; Thompson, Alexander G; Turner, Martin R; Talbot, Kevin

Cellular and axonal transport phenotypes due to the C9ORF72 HRE in iPSC motor and sensory neurons

iPSC运动和感觉神经元中C9ORF72 HRE引起的细胞和轴突运输表型

Scaber, Jakub; Thomas-Wright, Iona; Clark, Alex J; Xu, Yinyan; Vahsen, Björn F; Carcolé, Mireia; Dafinca, Ruxandra; Farrimond, Lucy; Isaacs, Adrian M; Bennett, David L; Talbot, Kevin

Dynactin-1 mediates rescue of impaired axonal transport due to reduced mitochondrial bioenergetics in amyotrophic lateral sclerosis motor neurons

Dynactin-1 介导修复肌萎缩侧索硬化症运动神经元中因线粒体生物能量减少而受损的轴突运输

Ruxandra Dafinca, Carlota Tosat-Bitrian, Emily Carroll, Björn F Vahsen, Javier Gilbert-Jaramillo, Jakub Scaber, Emily Feneberg, Errin Johnson, Kevin Talbot

C9orf72-ALS human iPSC microglia are pro-inflammatory and toxic to co-cultured motor neurons via MMP9

C9orf72-ALS 人类 iPSC 小胶质细胞通过 MMP9 具有促炎作用,并对共培养的运动神经元具有毒性

Björn F Vahsen, Sumedha Nalluru, Georgia R Morgan, Lucy Farrimond, Emily Carroll, Yinyan Xu, Kaitlyn M L Cramb, Benazir Amein, Jakub Scaber, Antigoni Katsikoudi, Ana Candalija, Mireia Carcolé, Ruxandra Dafinca, Adrian M Isaacs, Richard Wade-Martins, Elizabeth Gray, Martin R Turner, Sally A Cowley, K

Advantages of routine next-generation sequencing over standard genetic testing in the amyotrophic lateral sclerosis clinic

在肌萎缩侧索硬化症诊所中,常规二代测序相对于标准基因检测的优势

Scaber, Jakub; Thompson, Alexander G; Farrimond, Lucy; Feneberg, Emily; Proudfoot, Malcolm; Ossher, Lynn; Turner, Martin R; Talbot, Kevin

Human stem cell models of neurodegeneration: From basic science of amyotrophic lateral sclerosis to clinical translation

神经退行性疾病的人类干细胞模型:从肌萎缩侧索硬化症的基础科学到临床转化

Elisa Giacomelli, Björn F Vahsen, Elizabeth L Calder, Yinyan Xu, Jakub Scaber, Elizabeth Gray, Ruxandra Dafinca, Kevin Talbot, Lorenz Studer

Multicentre appraisal of amyotrophic lateral sclerosis biofluid biomarkers shows primacy of blood neurofilament light chain

多中心肌萎缩侧索硬化症生物体液标志物评估显示,血液神经丝轻链起主导作用

Thompson, Alexander G; Gray, Elizabeth; Verber, Nick; Bobeva, Yoana; Lombardi, Vittoria; Shepheard, Stephanie R; Yildiz, Ozlem; Feneberg, Emily; Farrimond, Lucy; Dharmadasa, Thanuja; Gray, Pamela; Edmond, Evan C; Scaber, Jakub; Gagliardi, Delia; Kirby, Janine; Jenkins, Thomas M; Fratta, Pietro; McDermott, Christopher J; Manohar, Sanjay G; Talbot, Kevin; Malaspina, Andrea; Shaw, Pamela J; Turner, Martin R

Human iPSC co-culture model to investigate the interaction between microglia and motor neurons

利用人诱导多能干细胞共培养模型研究小胶质细胞与运动神经元之间的相互作用

Björn F Vahsen ,Elizabeth Gray ,Ana Candalija ,Kaitlyn M L Cramb ,Jakub Scaber ,Ruxandra Dafinca ,Antigoni Katsikoudi ,Yinyan Xu ,Lucy Farrimond ,Richard Wade-Martins ,William S James ,Martin R Turner ,Sally A Cowley ,Kevin Talbot

Genetic testing in motor neurone disease

运动神经元疾病的基因检测

Dharmadasa, Thanuja; Scaber, Jakub; Edmond, Evan; Marsden, Rachael; Thompson, Alexander; Talbot, Kevin; Turner, Martin R

Impairment of Mitochondrial Calcium Buffering Links Mutations in C9ORF72 and TARDBP in iPS-Derived Motor Neurons from Patients with ALS/FTD

线粒体钙缓冲功能障碍与肌萎缩侧索硬化症/额颞叶痴呆症患者诱导多能干细胞来源的运动神经元中C9ORF72和TARDBP基因突变相关。

Ruxandra Dafinca ,Paola Barbagallo ,Lucy Farrimond ,Ana Candalija ,Jakub Scaber ,Nida'a A Ababneh ,Chaitra Sathyaprakash ,Jane Vowles ,Sally A Cowley ,Kevin Talbot