日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Dissociation kinetics of G proteins from G protein-coupled receptors and effects of allosteric modulation

G蛋白与G蛋白偶联受体的解离动力学及变构调节效应

Wang, Jinan; Nguyen, Anh T N; Adediwura, Victor A; Lu, Cam Sinh; McNeill, Samantha M; Jörg, Manuela; Scammells, Peter J; Christopoulos, Arthur; May, Lauren T; Miao, Yinglong

Structure-based discovery of positive allosteric modulators of the A(1) adenosine receptor

基于结构的A(1)腺苷受体正向变构调节剂的发现

Nguyen, Anh T N; Panel, Nicolas; Vo, Duc Duy; Thai, Bui San; Chia, Ling Yeong; Lu, Cam Sinh; Hellyer, Shane D; Langiu, Monica; Jörg, Manuela; Gregory, Karen J; Kihlberg, Jan; White, Paul J; Scammells, Peter J; Christopoulos, Arthur; Carlsson, Jens; May, Lauren T

Structure-guided allosteric modulation of the delta opioid receptor

结构导向的δ阿片受体变构调节

Mobbs, Jesse I; Nguyen, M Deborah; Deo, Owindeep; Bartuzi, Damian; Venugopal, Hariprasad; Alvi, Sadia; Pham, Vi; Barnes, Nick; Christopoulos, Arthur; Poole, Daniel P; Carbone, Simona E; Jörg, Manuela; Capuano, Ben; Carlsson, Jens; Gondin, Arisbel B; Scammells, Peter J; Valant, Celine; Thal, David M

Ligand-Directed Labeling of the Adenosine A1 Receptor in Living Cells

活细胞中腺苷 A1 受体的配体指导标记

Eleonora Comeo, Joëlle Goulding, Chia-Yang Lin, Marleen Groenen, Jeanette Woolard, Nicholas D Kindon, Clare R Harwood, Simon Platt, Stephen J Briddon, Laura E Kilpatrick, Peter J Scammells, Stephen J Hill, Barrie Kellam

Chemoproteomics validates selective targeting of Plasmodium M1 alanyl aminopeptidase as an antimalarial strategy

化学蛋白质组学验证了选择性靶向疟原虫 M1 丙氨酰氨基肽酶作为抗疟策略

Carlo Giannangelo #, Matthew P Challis #, Ghizal Siddiqui, Rebecca Edgar, Tess R Malcolm, Chaille T Webb, Nyssa Drinkwater, Natalie Vinh, Christopher Macraild, Natalie Counihan, Sandra Duffy, Sergio Wittlin, Shane M Devine, Vicky M Avery, Tania De Koning-Ward, Peter Scammells, Sheena McGowan, Darren

Genetic and chemical validation of Plasmodium falciparum aminopeptidase Pf A-M17 as a drug target in the hemoglobin digestion pathway

恶性疟原虫氨基肽酶 Pf A-M17 作为血红蛋白消化途径药物靶点的遗传和化学验证

Rebecca C S Edgar, Ghizal Siddiqui, Katheryn Hjerrild, Tess R Malcolm, Natalie B Vinh, Chaille T Webb, Clare Holmes, Christopher A MacRaild, Hope C Chernih, Willy W Suen, Natalie A Counihan, Darren J Creek, Peter J Scammells, Sheena McGowan, Tania F de Koning-Ward

Biocompatible Cationic Lipoamino Acids as Counterions for Oral Administration of API-Ionic Liquids

生物相容性阳离子脂氨基酸作为口服给药API离子液体的抗衡离子

Lai, Anthony; Leong, Nathania; Zheng, Dan; Ford, Leigh; Nguyen, Tri-Hung; Williams, Hywel D; Benameur, Hassan; Scammells, Peter J; Porter, Christopher J H

Positive allosteric mechanisms of adenosine A1 receptor-mediated analgesia

腺苷A1受体介导镇痛的正变构机制

Christopher J Draper-Joyce, Rebecca Bhola, Jinan Wang, Apurba Bhattarai, Anh T N Nguyen, India Cowie-Kent, Kelly O'Sullivan, Ling Yeong Chia, Hariprasad Venugopal, Celine Valant, David M Thal, Denise Wootten, Nicolas Panel, Jens Carlsson, Macdonald J Christie, Paul J White, Peter Scammells, Lauren T

The effect of two selective A1 -receptor agonists and the bitopic ligand VCP746 on heart rate and regional vascular conductance in conscious rats

两种选择性 A1 受体激动剂和双位配体 VCP746 对清醒大鼠心率和局部血管传导的影响

Samantha L Cooper, Julie March, Andrea R Sabbatini, Stephen J Hill, Manuela Jörg, Peter J Scammells, Jeanette Woolard

API ionic liquids: probing the effect of counterion structure on physical form and lipid solubility

API 离子液体:探究反离子结构对物理形态和脂质溶解度的影响

Leigh Ford, Erin Tay, Tri-Hung Nguyen, Hywel D Williams, Hassan Benameur, Peter J Scammells, Christopher J H Porter