日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Methods to accelerate PROTAC drug discovery

加速PROTAC药物发现的方法

Osman, Jeyan; Thompson, Philip E; Jörg, Manuela; Scanlon, Martin J

Exploring the Ligandability of 53BP1 through Fragment-Based Approaches

通过基于片段的方法探索53BP1的配体结合能力

Chiew, Beatrice; Gunzburg, Menachem J; Foley, Caroline A; Zeng, Hong; Dong, Aiping; Brown, Peter J; The, Juliana; Norris-Drouin, Jacqueline L; Cholensky, Stephanie H; Mohanty, Biswaranjan; Scanlon, Martin J; Headey, Stephen J; Doak, Bradley C; James, Lindsey I

Identification of an Allene Warhead That Selectively Targets a Histidine Residue in the Escherichia coli Oxidoreductase Enzyme DsbA

鉴定出一种能选择性靶向大肠杆菌氧化还原酶DsbA中组氨酸残基的丙二烯弹头

Tasdan, Yildiz; Balaji, Gautham R; Akhtar, Naureen; Ilyichova, Olga; Cunliffe, Taylor; Heras, Begoña; Strat, Loic Le; Murray, James; Capuano, Ben; Scanlon, Martin J; Doak, Bradley C

Evaluation of the Anti-Inflammatory Effects of Novel Fatty Acid-Binding Protein 4 Inhibitors in Microglia.

评价新型脂肪酸结合蛋白4抑制剂对小胶质细胞的抗炎作用

Low Yi Ling, Kreutzer Ethan, Chandrashekaran Indu R, Adams Luke A, Pun Jason, Doak Bradley C, Pan Yijun, Short Jennifer L, Scanlon Martin J, Nicolazzo Joseph A

Identification and characterization of two drug-like fragments that bind to the same cryptic binding pocket of Burkholderia pseudomallei DsbA

鉴定并表征了两种与类鼻疽伯克霍尔德菌DsbA蛋白同一隐蔽结合口袋结合的类药片段

Petit, Guillaume A; Mohanty, Biswaranjan; McMahon, Róisín M; Nebl, Stefan; Hilko, David H; Wilde, Karyn L; Scanlon, Martin J; Martin, Jennifer L; Halili, Maria A

Inhibition of Diverse DsbA Enzymes in Multi-DsbA Encoding Pathogens

抑制多种编码DsbA的病原体中的多种DsbA酶

Totsika, Makrina; Vagenas, Dimitrios; Paxman, Jason J; Wang, Geqing; Dhouib, Rabeb; Sharma, Pooja; Martin, Jennifer L; Scanlon, Martin J; Heras, Begoña

Production, biophysical characterization and initial crystallization studies of the N- and C-terminal domains of DsbD, an essential enzyme in Neisseria meningitidis

对脑膜炎奈瑟菌必需酶DsbD的N端和C端结构域进行了生产、生物物理表征和初步结晶研究。

Smith, Roxanne P; Whitten, Andrew E; Paxman, Jason J; Kahler, Charlene M; Scanlon, Martin J; Heras, Begoña

Neurokinin 1 receptor signaling in endosomes mediates sustained nociception and is a viable therapeutic target for prolonged pain relief

神经激肽1受体在内体中的信号传导介导持续性伤害感受,是延长疼痛缓解的有效治疗靶点。

Jensen, Dane D; Lieu, TinaMarie; Halls, Michelle L; Veldhuis, Nicholas A; Imlach, Wendy L; Mai, Quynh N; Poole, Daniel P; Quach, Tim; Aurelio, Luigi; Conner, Joshua; Herenbrink, Carmen Klein; Barlow, Nicholas; Simpson, Jamie S; Scanlon, Martin J; Graham, Bimbil; McCluskey, Adam; Robinson, Phillip J; Escriou, Virginie; Nassini, Romina; Materazzi, Serena; Geppetti, Pierangelo; Hicks, Gareth A; Christie, Macdonald J; Porter, Christopher J H; Canals, Meritxell; Bunnett, Nigel W

Binding of CFA/I Pili of Enterotoxigenic Escherichia coli to Asialo-GM1 Is Mediated by the Minor Pilin CfaE

产肠毒素大肠杆菌的CFA/I菌毛与Asialo-GM1的结合是由次要菌毛蛋白CfaE介导的。

Madhavan, T P Vipin; Riches, James D; Scanlon, Martin J; Ulett, Glen C; Sakellaris, Harry

The role of oxidoreductases in determining the function of the neisserial lipid A phosphoethanolamine transferase required for resistance to polymyxin

氧化还原酶在决定奈瑟菌脂质A磷酸乙醇胺转移酶的功能中的作用,该酶是多粘菌素耐药所必需的。

Piek, Susannah; Wang, Zhirui; Ganguly, Jhuma; Lakey, Adam M; Bartley, Stephanie N; Mowlaboccus, Shakeel; Anandan, Anandhi; Stubbs, Keith A; Scanlon, Martin J; Vrielink, Alice; Azadi, Parastoo; Carlson, Russell W; Kahler, Charlene M