Dual inactivation of Akt and ERK by TIC10 signals Foxo3a nuclear translocation, TRAIL gene induction, and potent antitumor effects
TIC10 使 Akt 和 ERK 双重失活,发出 Foxo3a 核易位、TRAIL 基因诱导和有效的抗肿瘤作用
期刊:Science Translational Medicine
影响因子:15.8
doi:10.1126/scitranslmed.3004828
Joshua E Allen, Gabriel Krigsfeld, Patrick A Mayes, Luv Patel, David T Dicker, Akshal S Patel, Nathan G Dolloff, Evangelos Messaris, Kimberly A Scata, Wenge Wang, Jun-Ying Zhou, Gen Sheng Wu, Wafik S El-Deiry