日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Investigational eIF2B activator DNL343 modulates the integrated stress response in preclinical models of TDP-43 pathology and individuals with ALS in a randomized clinical trial

在随机临床试验中,研究性 eIF2B 激活剂 DNL343 可调节 TDP-43 病理临床前模型和 ALS 患者的整合应激反应。

Brittany N Flores # ,Seungyoon B Yu # ,Isaac V Cohen # ,Melania H Fanok # ,Wei Luan ,Romeo D Maciuca ,Linus D Sun ,Richard M Tsai ,Maurits Vissers ,Lars Smits ,Tommy M Bunte ,Anna Bakardjiev ,Srijana Balasundar ,Meredith E K Calvert ,Marcus Y Chin ,Sarah K Dobbins ,William E Dowdle ,Meng Fang ,Jules A A C Heuberger ,Connie L Ha ,Fen Huang ,Takashi Miyamoto ,Maksim Osipov ,Lidia Madrid San Martin ,Katie Saund ,David Tatarakis ,Anthony Q Vu ,Chenling Xiong ,Gene W Yeo ,Geert Jan Groeneveld ,Leonard H van den Berg ,Shyeilla Dhuria ,Anthony A Estrada ,Danna Jennings ,Thomas Sandmann ,Carole Ho ,Kimberly Scearce-Levie ,Ernie Yulyaningsih ,Adam K Walker ,Gilbert Di Paolo ,Lesley A Kane ,Matthew D Troyer ,Joseph W Lewcock

The brain trancytosome: pooled in vivo screening of 1000s of biologics discovers novel “portal” receptors and mechanisms for macromolecule CNS delivery

脑内转运体:对数千种生物制剂进行体内联合筛选,发现新型“门户”受体和大分子中枢神经系统递送机制

Gong, Tao; Liu, Yubo; Chen, Yufan; Lin, Liangjie; Lin, Youting; Wang, Guangbin; Scearce‐Levie, Kimberly; Ogden, Pierce; Albuja, Isabel; Anam, Fabliha; Anand, Anisha; Avera, John; Braun, Allie; Carroll, Sean; Case, Marshall; Duffy, Karen; Garcia, Alvaro; Gerew, Alex; Gourdeau, Jack; Haddad, Hala; Hauk, Glenn; Ho‐Rath, Yendee; Kuznetsov, Gleb; Lofgren, Shane; Malekoltojari, Ainaz; Mehmood, Roasa; Mehta, Naveen; Nichols, Mike; Prescott, Maggie; Ravichandran, Supriva; Reis, Alex; Shah, Manan; Sun, Tianxiao; Swanson, Erik; Wipke, Brian; Nudel, Kate

A Pentavalent HIV-1 Subtype C Vaccine Containing Computationally Selected gp120 Strains Improves the Breadth of V1V2 Region Responses

含有经计算机筛选的gp120毒株的五价HIV-1 C亚型疫苗可提高V1V2区免疫应答的广度

Shen, Xiaoying; Korber, Bette; Spreng, Rachel L; Sawant, Sheetal S; deCamp, Allan; McMillan, Arthur S; Mathura, Ryan; Zolla-Pazner, Susan; Pinter, Abraham; Parks, Robert; Bowman, Cindy; Sutherland, Laura; Scearce, Richard; Yates, Nicole L; Montefiori, David C; Haynes, Barton F; Tomaras, Georgia D

Cellular signatures of vulnerability and resilience in Alzheimer's Disease brains

阿尔茨海默病大脑中脆弱性和恢复力的细胞特征

Han, Jia; Bastian, Björn; Jorewitz, Marcel; Asmis, Knut R; Jin, Jiaye; Lin, Chien Hong; Chen, Shang Hung; Hsu, Chia‐Yu; Wang, Hui‐Chen; Su, Ih‐Jen; Zhou, Robin Ziyue; Gaunitz, Stefan; Skoldunger, Anders; Wimo, Anders; Winblad, Bengt; Fladby, Tormod; Weiss, Sophia Schedin; Tjernberg, Lars O; Scearce‐Levie, Kimberly; Ogden, Pierce; Albuja, Isabel; Anam, Fabliha; Anand, Anisha; Avera, John; Braun, Allie; Carroll, Sean; Case, Marshall; Duffy, Karen; Garcia, Alvaro; Gerew, Alex; Gourdeau, Jack; Haddad, Hala; Hauk, Glenn; Ho‐Rath, Yendee; Kuznetsov, Gleb; Lofgren, Shane; Malekoltojari, Ainaz; Mehmood, Roasa; Mehta, Naveen; Nichols, Mike; Prescott, Maggie; Ravichandran, Supriva; Reis, Alex; Shah, Manan; Sun, Tianxiao; Swanson, Erik; Wipke, Brian; Nudel, Kate; Pantoja, Anallely; Díaz‐Miranda, Sofía; Martínez‐Orozco, Humberto; Aguilar‐Vázquez, Azucena; Andrade‐Guerrero, Jesús; Hernández‐Puga, Ana Gabriela; Soto‐Rojas, Luis Oskar; Sonpee, Chanikarn; Ruchisrisarod, Chanida; Hemachudha, Pasin; Supharatpariyakorn, Thirawat; Luechaipanit, Watayuth; Saraya, Abhinbhen Wasontiwong; Thanapornsangsuth, Poosanu; Zhunussova, Alina; Loane, Clare; Kurt, Elif; Femminella, Grazia Daniela; Lenzoni, Sabrina; Duckett, Millie; Callaghan, Martina F; Weiskopf, Nikolaus; Dolan, Raymond J; Howard, Robert; Düzel, Emrah; Hämmerer, Dorothea; Baldasso, Gabriela Mantovani; Limberger, Christian; Salvadori, Sofia Gallo; Paes, Rodrigo Sebben; Bastiani, Marco Antônio De; Zimmer, Eduardo R

The brain trancytosome: pooled in vivo screening of 1000s of biologics discovers novel “portal” receptors and mechanisms for macromolecule CNS delivery

脑内转运体:对数千种生物制剂进行体内联合筛选,发现新型“门户”受体和大分子中枢神经系统递送机制

Ntais, Christos; Kontodimopoulos, Nikolaos; Fanourgiakis, John; Talias, Michael A; Scearce‐Levie, Kimberly; Ogden, Pierce; Albuja, Isabel; Anam, Fabliha; Anand, Anisha; Avera, John; Braun, Allie; Carroll, Sean; Case, Marshall; Duffy, Karen; Garcia, Alvaro; Gerew, Alex; Gourdeau, Jack; Haddad, Hala; Hauk, Glenn; Ho‐Rath, Yendee; Kuznetsov, Gleb; Lofgren, Shane; Malekoltojari, Ainaz; Mehmood, Roasa; Mehta, Naveen; Nichols, Mike; Prescott, Maggie; Ravichandran, Supriva; Reis, Alex; Shah, Manan; Sun, Tianxiao; Swanson, Erik; Wipke, Brian; Nudel, Kate

A TREM2-activating antibody with a blood-brain barrier transport vehicle enhances microglial metabolism in Alzheimer's disease models

一种带有血脑屏障转运载体的TREM2激活抗体可增强阿尔茨海默病模型中的小胶质细胞代谢。

Bettina van Lengerich # ,Lihong Zhan # ,Dan Xia # ,Darren Chan ,David Joy ,Joshua I Park ,David Tatarakis ,Meredith Calvert ,Selina Hummel ,Steve Lianoglou ,Michelle E Pizzo ,Rachel Prorok ,Elliot Thomsen ,Laura M Bartos ,Philipp Beumers ,Anja Capell ,Sonnet S Davis ,Lis de Weerd ,Jason C Dugas ,Joseph Duque ,Timothy Earr ,Kapil Gadkar ,Tina Giese ,Audrey Gill ,Johannes Gnörich ,Connie Ha ,Malavika Kannuswamy ,Do Jin Kim ,Sebastian T Kunte ,Lea H Kunze ,Diana Lac ,Kendra Lechtenberg ,Amy Wing-Sze Leung ,Chun-Chi Liang ,Isabel Lopez ,Paul McQuade ,Anuja Modi ,Vanessa O Torres ,Hoang N Nguyen ,Ida Pesämaa ,Nicholas Propson ,Marvin Reich ,Yaneth Robles-Colmenares ,Kai Schlepckow ,Luna Slemann ,Hilda Solanoy ,Jung H Suh ,Robert G Thorne ,Chandler Vieira ,Karin Wind-Mark ,Ken Xiong ,Y Joy Yu Zuchero ,Dolo Diaz ,Mark S Dennis ,Fen Huang ,Kimberly Scearce-Levie ,Ryan J Watts ,Christian Haass ,Joseph W Lewcock ,Gilbert Di Paolo ,Matthias Brendel ,Pascal E Sanchez ,Kathryn M Monroe

Novel App knock-in mouse model shows key features of amyloid pathology and reveals profound metabolic dysregulation of microglia

新型应用程序敲入小鼠模型展现了淀粉样蛋白病理的关键特征,并揭示了小胶质细胞严重的代谢紊乱。

Dan Xia # ,Steve Lianoglou # ,Thomas Sandmann ,Meredith Calvert ,Jung H Suh ,Elliot Thomsen ,Jason Dugas ,Michelle E Pizzo ,Sarah L DeVos ,Timothy K Earr ,Chia-Ching Lin ,Sonnet Davis ,Connie Ha ,Amy Wing-Sze Leung ,Hoang Nguyen ,Roni Chau ,Ernie Yulyaningsih ,Isabel Lopez ,Hilda Solanoy ,Shababa T Masoud ,Chun-Chi Liang ,Karin Lin ,Giuseppe Astarita ,Nathalie Khoury ,Joy Yu Zuchero ,Robert G Thorne ,Kevin Shen ,Stephanie Miller ,Jorge J Palop ,Dylan Garceau ,Michael Sasner ,Jennifer D Whitesell ,Julie A Harris ,Selina Hummel ,Johannes Gnörich ,Karin Wind ,Lea Kunze ,Artem Zatcepin ,Matthias Brendel ,Michael Willem ,Christian Haass ,Daniel Barnett ,Till S Zimmer ,Anna G Orr ,Kimberly Scearce-Levie ,Joseph W Lewcock ,Gilbert Di Paolo ,Pascal E Sanchez

Stabilized HIV-1 envelope immunization induces neutralizing antibodies to the CD4bs and protects macaques against mucosal infection

稳定的HIV-1包膜免疫可诱导产生针对CD4结合位点的中和抗体,并保护猕猴免受黏膜感染。

Saunders, Kevin O; Edwards, Robert J; Tilahun, Kedamawit; Manne, Kartik; Lu, Xiaozhi; Cain, Derek W; Wiehe, Kevin; Williams, Wilton B; Mansouri, Katayoun; Hernandez, Giovanna E; Sutherland, Laura; Scearce, Richard; Parks, Robert; Barr, Maggie; DeMarco, Todd; Eater, Chloe M; Eaton, Amanda; Morton, Georgeanna; Mildenberg, Benjamin; Wang, Yunfei; Rountree, R Wes; Tomai, Mark A; Fox, Christopher B; Moody, M Anthony; Alam, S Munir; Santra, Sampa; Lewis, Mark G; Denny, Thomas N; Shaw, George M; Montefiori, David C; Acharya, Priyamvada; Haynes, Barton F

Mouse and human antibodies bind HLA-E-leader peptide complexes and enhance NK cell cytotoxicity

小鼠和人类抗体与HLA-E-前导肽复合物结合,增强NK细胞的细胞毒性。

Dapeng Li # ,Simon Brackenridge # ,Lucy C Walters # ,Olivia Swanson ,Karl Harlos ,Daniel Rozbesky ,Derek W Cain ,Kevin Wiehe ,Richard M Scearce ,Maggie Barr ,Zekun Mu ,Robert Parks ,Max Quastel ,Robert J Edwards ,Yunfei Wang ,Wes Rountree ,Kevin O Saunders ,Guido Ferrari ,Persephone Borrow ,E Yvonne Jones ,S Munir Alam ,Mihai L Azoitei ,Geraldine M Gillespie ,Andrew J McMichael ,Barton F Haynes

Safety, pharmacokinetics and target engagement of novel RIPK1 inhibitor SAR443060 (DNL747) for neurodegenerative disorders: Randomized, placebo-controlled, double-blind phase I/Ib studies in healthy subjects and patients

新型RIPK1抑制剂SAR443060 (DNL747)治疗神经退行性疾病的安全性、药代动力学和靶点结合:在健康受试者和患者中进行的随机、安慰剂对照、双盲I/Ib期研究

Vissers, Maurits F J M; Heuberger, Jules A A C; Groeneveld, Geert Jan; Oude Nijhuis, Jerome; De Deyn, Peter Paul; Hadi, Salah; Harris, Jeffrey; Tsai, Richard M; Cruz-Herranz, Andres; Huang, Fen; Tong, Vincent; Erickson, Rebecca; Zhu, Yuda; Scearce-Levie, Kimberly; Hsiao-Nakamoto, Jennifer; Tang, Xinyan; Chang, Megan; Fox, Brian M; Estrada, Anthony A; Pomponio, Robert J; Alonso-Alonso, Miguel; Zilberstein, Moshe; Atassi, Nazem; Troyer, Matthew D; Ho, Carole