日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Safety, pharmacokinetics, and pharmacodynamics of MK-6194, an IL-2 mutein designed to selectively activate regulatory T cells: single ascending dose and multiple ascending dose trial data.

MK-6194(一种旨在选择性激活调节性 T 细胞的 IL-2 突变体)的安全性、药代动力学和药效学:单次递增剂量和多次递增剂量试验数据

Scheid Johannes F, Cunningham-Bussel Kiki, Kim Nancy, Agarwal Shiuli, Nieddu Garrett, Cote Josee, Lemoine Lieselotte, Decaesteker Tatjana, Mendez Luis, Paul Erina, Love-Gregory Latisha, Contreras Alejandra Virginia, Zhao Xuemei, Franco-Dilone Lucia, Pang Ling, Baltus Gretchen A, Beaumont Maribel, Shah Ketal, Higginson-Scott Nathan, Kis-Toth Katalin, Otipoby Kevin L, Viney Joanne L, Sicard Eric, Rottey Sylvie, Sundy John S, Van Dyck Kristien, Laethem Tine, Larson Patrick, Sutradhar Santosh, Wnek Richard, Bueters Tjerk, Lai Eseng, Stoch S Aubrey, Iwamoto Marian, Robbins Jonathan A

Successful Treatment of Refractory Autoimmune Enteropathy With Ustekinumab

乌司奴单抗成功治疗难治性自身免疫性肠病

Scheid, Johannes F; Misdraji, Joseph; Nath, Barbara J; Yarze, Joseph C

HIV-1 Neutralizing Antibody Signatures and Application to Epitope-Targeted Vaccine Design

HIV-1中和抗体特征及其在表位靶向疫苗设计中的应用

Bricault, Christine A; Yusim, Karina; Seaman, Michael S; Yoon, Hyejin; Theiler, James; Giorgi, Elena E; Wagh, Kshitij; Theiler, Maxwell; Hraber, Peter; Macke, Jennifer P; Kreider, Edward F; Learn, Gerald H; Hahn, Beatrice H; Scheid, Johannes F; Kovacs, James M; Shields, Jennifer L; Lavine, Christy L; Ghantous, Fadi; Rist, Michael; Bayne, Madeleine G; Neubauer, George H; McMahan, Katherine; Peng, Hanqin; Chéneau, Coraline; Jones, Jennifer J; Zeng, Jie; Ochsenbauer, Christina; Nkolola, Joseph P; Stephenson, Kathryn E; Chen, Bing; Gnanakaran, S; Bonsignori, Mattia; Williams, LaTonya D; Haynes, Barton F; Doria-Rose, Nicole; Mascola, John R; Montefiori, David C; Barouch, Dan H; Korber, Bette

Structural Repertoire of HIV-1-Neutralizing Antibodies Targeting the CD4 Supersite in 14 Donors

14名捐献者体内靶向CD4超位点的HIV-1中和抗体的结构谱

Zhou, Tongqing; Lynch, Rebecca M; Chen, Lei; Acharya, Priyamvada; Wu, Xueling; Doria-Rose, Nicole A; Joyce, M Gordon; Lingwood, Daniel; Soto, Cinque; Bailer, Robert T; Ernandes, Michael J; Kong, Rui; Longo, Nancy S; Louder, Mark K; McKee, Krisha; O'Dell, Sijy; Schmidt, Stephen D; Tran, Lillian; Yang, Zhongjia; Druz, Aliaksandr; Luongo, Timothy S; Moquin, Stephanie; Srivatsan, Sanjay; Yang, Yongping; Zhang, Baoshan; Zheng, Anqi; Pancera, Marie; Kirys, Tatsiana; Georgiev, Ivelin S; Gindin, Tatyana; Peng, Hung-Pin; Yang, An-Suei; Mullikin, James C; Gray, Matthew D; Stamatatos, Leonidas; Burton, Dennis R; Koff, Wayne C; Cohen, Myron S; Haynes, Barton F; Casazza, Joseph P; Connors, Mark; Corti, Davide; Lanzavecchia, Antonio; Sattentau, Quentin J; Weiss, Robin A; West, Anthony P Jr; Bjorkman, Pamela J; Scheid, Johannes F; Nussenzweig, Michel C; Shapiro, Lawrence; Mascola, John R; Kwong, Peter D

HIV antibodies. Antigen modification regulates competition of broad and narrow neutralizing HIV antibodies

HIV抗体。抗原修饰调节广谱和窄谱中和HIV抗体的竞争。

McGuire, Andrew T; Dreyer, Anita M; Carbonetti, Sara; Lippy, Adriana; Glenn, Jolene; Scheid, Johannes F; Mouquet, Hugo; Stamatatos, Leonidas

Structural insights on the role of antibodies in HIV-1 vaccine and therapy

关于抗体在HIV-1疫苗和治疗中的作用的结构性见解

West, Anthony P Jr; Scharf, Louise; Scheid, Johannes F; Klein, Florian; Bjorkman, Pamela J; Nussenzweig, Michel C

Antibodies in HIV-1 vaccine development and therapy

HIV-1疫苗研发和治疗中的抗体

Klein, Florian; Mouquet, Hugo; Dosenovic, Pia; Scheid, Johannes F; Scharf, Louise; Nussenzweig, Michel C

Engineering HIV envelope protein to activate germline B cell receptors of broadly neutralizing anti-CD4 binding site antibodies

通过基因工程改造HIV包膜蛋白,激活广谱中和抗CD4结合位点抗体的生殖系B细胞受体。

McGuire, Andrew T; Hoot, Sam; Dreyer, Anita M; Lippy, Adriana; Stuart, Andrew; Cohen, Kristen W; Jardine, Joseph; Menis, Sergey; Scheid, Johannes F; West, Anthony P; Schief, William R; Stamatatos, Leonidas

Broadly neutralizing antibodies that inhibit HIV-1 cell to cell transmission

能抑制HIV-1细胞间传播的广谱中和抗体

Malbec, Marine; Porrot, Françoise; Rua, Rejane; Horwitz, Joshua; Klein, Florian; Halper-Stromberg, Ari; Scheid, Johannes F; Eden, Caroline; Mouquet, Hugo; Nussenzweig, Michel C; Schwartz, Olivier

Broadly neutralizing antibodies developed by an HIV-positive elite neutralizer exact a replication fitness cost on the contemporaneous virus

由HIV阳性精英中和者产生的广谱中和抗体对同期病毒的复制适应性造成了显著影响。

Sather, D Noah; Carbonetti, Sara; Kehayia, Jenny; Kraft, Zane; Mikell, Iliyana; Scheid, Johannes F; Klein, Florian; Stamatatos, Leonidas