日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Distinct tau filament folds in human MAPT mutants P301L and P301T

人类MAPT突变体P301L和P301T中tau蛋白丝的独特折叠

Schweighauser, Manuel; Shi, Yang; Murzin, Alexey G; Garringer, Holly J; Vidal, Ruben; Murrell, Jill R; Erro, M Elena; Seelaar, Harro; Ferrer, Isidro; van Swieten, John C; Ghetti, Bernardino; Scheres, Sjors H W; Goedert, Michel

Tau filaments with the Alzheimer fold in human MAPT mutants V337M and R406W

人类 MAPT 突变体 V337M 和 R406W 中具有阿尔茨海默病折叠的 Tau 丝

Qi, Chao; Lövestam, Sofia; Murzin, Alexey G; Peak-Chew, Sew; Franco, Catarina; Bogdani, Marika; Latimer, Caitlin; Murrell, Jill R; Cullinane, Patrick W; Jaunmuktane, Zane; Bird, Thomas D; Ghetti, Bernardino; Scheres, Sjors H W; Goedert, Michel

GSK3β phosphorylated tau filaments are probably not like those from AD brains

GSK3β磷酸化的tau蛋白丝可能与阿尔茨海默病脑组织中的tau蛋白丝不同。

Scheres, Sjors H W

Cryo-EM structure of the vault from human brain reveals symmetry mismatch at its caps

人脑穹窿的冷冻电镜结构揭示其顶部存在对称性不匹配

Lövestam, Sofia; Scheres, Sjors H W

Seeding biosensor cell line that reproduces the Alzheimer tau fold.

建立能够重现阿尔茨海默病 tau 折叠的生物传感器细胞系。

Katsinelos Taxiarchis, Lövestam Sofia, Qi Chao, Ryskeldi-Falcon Benjamin, Macdonald Jennifer A, Stephenson Gabriel, Ghetti Bernardino, McKee Ann, Scheres Sjors H W, Goedert Michel

Serial amplification of tau filaments using Alzheimer's brain homogenates and C322A or C322S recombinant tau

利用阿尔茨海默病脑匀浆和C322A或C322S重组tau蛋白进行tau蛋白丝的连续扩增

Santambrogio, Alessia; Lövestam, Sofia; Metrick, Michael A 2nd; Löhr, Thomas; Xu, Peifeng; Gallagher, Nicholas C T; Ghetti, Bernardino; Caughey, Byron; Scheres, Sjors H W; Vendruscolo, Michele

Automated model building and protein identification in cryo-EM maps

冷冻电镜图谱中的自动模型构建和蛋白质鉴定

Jamali, Kiarash; Käll, Lukas; Zhang, Rui; Brown, Alan; Kimanius, Dari; Scheres, Sjors H W

DynaMight: estimating molecular motions with improved reconstruction from cryo-EM images

DynaMight:利用改进的冷冻电镜图像重建技术估算分子运动

Schwab, Johannes; Kimanius, Dari; Burt, Alister; Dendooven, Tom; Scheres, Sjors H W

Data-driven regularization lowers the size barrier of cryo-EM structure determination

数据驱动的正则化降低了冷冻电镜结构测定的尺寸限制

Kimanius, Dari; Jamali, Kiarash; Wilkinson, Max E; Lövestam, Sofia; Velazhahan, Vaithish; Nakane, Takanori; Scheres, Sjors H W

Tau filaments with the chronic traumatic encephalopathy fold in a case of vacuolar tauopathy with VCP mutation D395G

在伴有VCP基因突变D395G的空泡性tau蛋白病病例中,tau蛋白丝与慢性创伤性脑病褶皱相连。

Qi, Chao; Kobayashi, Ryota; Kawakatsu, Shinobu; Kametani, Fuyuki; Scheres, Sjors H W; Goedert, Michel; Hasegawa, Masato