日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

The Human Chk1 Inhibitor CHIR-124 Shows Multistage Activity Against Plasmodium falciparum via Dual Inhibition of PfArk1 and Hemozoin Formation

人源Chk1抑制剂CHIR-124通过双重抑制PfArk1和血红素形成,对恶性疟原虫表现出多阶段活性。

Wicht, Kathryn J; Woodland, John G; Garnie, Larnelle F; Langeveld, Henrico; Taylor, Dale; Godoy, Luiz C; Pasaje, Charisse Flerida A; de Souza, Mariana Laureano; Siqueira-Neto, Jair L; Ghidelli-Disse, Sonja; Lafuente-Monasterio, Maria Jose; Gamo, Francisco-Javier; Coertzen, Dina; Reader, Janette; van der Watt, Mariëtte; Bridgford, Jessica L; Girling, Gareth; Coyle, Rachael; Scheurer, Christian; Wittlin, Sergio; Lee, Marcus C S; Voss, Till S; Winzeler, Elizabeth A; Fidock, David A; Niles, Jacquin C; Birkholtz, Lyn-Marié; Coulson, Lauren B; Chibale, Kelly

Incomplete Plasmodium falciparum growth inhibition following piperaquine treatment translates into increased parasite viability in the in vitro parasite reduction ratio assay.

哌喹治疗后恶性疟原虫生长抑制不完全,导致体外寄生虫减少率试验中寄生虫存活率增加

Walz Annabelle, Sax Sibylle, Scheurer Christian, Tamasi Balint, Mäser Pascal, Wittlin Sergio

A Pyridyl-Furan Series Developed from the Open Global Health Library Block Red Blood Cell Invasion and Protein Trafficking in Plasmodium falciparum through Potential Inhibition of the Parasite's PI4KIIIB Enzyme

基于开放全球健康库开发的吡啶基呋喃系列化合物可通过潜在抑制寄生虫的PI4KIIIB酶,阻断恶性疟原虫的红细胞入侵和蛋白质运输。

Ling, Dawson B; Nguyen, William; Looker, Oliver; Razook, Zahra; McCann, Kirsty; Barry, Alyssa E; Scheurer, Christian; Wittlin, Sergio; Famodimu, Mufuliat Toyin; Delves, Michael J; Bullen, Hayley E; Crabb, Brendan S; Sleebs, Brad E; Gilson, Paul R

Antimalarial Dibenzannulated Medium-Ring Keto Lactams

抗疟疾二苯并环中环酮内酰胺类药物

Ren, Rongguo; Wang, Xiaofang; Leas, Derek A; Scheurer, Christian; Hoevel, Sarah; Cal, Monica; Chen, Gong; Zhong, Longjin; Katneni, Kasiram; Pham, Thao; Patil, Rahul; Sil, Diptesh; Walters, Matthias J; Schulze, Thomas T; Neville, Andrew J; Dong, Yuxiang; Wittlin, Sergio; Kaiser, Marcel; Davis, Paul H; Charman, Susan A; Vennerstrom, Jonathan L

Sorption of Nanomaterials to Sandstone Rock

纳米材料在砂岩上的吸附

Scheurer, Christian; Hincapie, Rafael E; Neubauer, Elisabeth; Metz, Astrid; Ness, Daniel

The 3-phosphoinositide-dependent protein kinase 1 is an essential upstream activator of protein kinase A in malaria parasites.

3-磷酸肌醇依赖性蛋白激酶 1 是疟原虫中蛋白激酶 A 的重要上游激活因子

Hitz Eva, Wiedemar Natalie, Passecker Armin, Graça Beatriz A S, Scheurer Christian, Wittlin Sergio, Brancucci Nicolas M B, Vakonakis Ioannis, Mäser Pascal, Voss Till S

Cytochrome P450-Mediated Metabolism and CYP Inhibition for the Synthetic Peroxide Antimalarial OZ439

合成过氧化物抗疟药OZ439的细胞色素P450介导代谢和CYP抑制

Shackleford, David M; Chiu, Francis C K; Katneni, Kasiram; Blundell, Scott; McLaren, Jenna; Wang, Xiaofang; Zhou, Lin; Sriraghavan, Kamaraj; Alker, André M; Hunziker, Daniel; Scheurer, Christian; Zhao, Qingjie; Dong, Yuxiang; Möhrle, Jörg J; Abla, Nada; Matile, Hugues; Wittlin, Sergio; Vennerstrom, Jonathan L; Charman, Susan A

In vitro activity of anti-malarial ozonides against an artemisinin-resistant isolate

抗疟臭素类化合物对青蒿素耐药分离株的体外活性

Baumgärtner, Fabian; Jourdan, Joëlle; Scheurer, Christian; Blasco, Benjamin; Campo, Brice; Mäser, Pascal; Wittlin, Sergio

Characterization of Novel Antimalarial Compound ACT-451840: Preclinical Assessment of Activity and Dose-Efficacy Modeling

新型抗疟化合物ACT-451840的特性研究:活性和剂量-疗效模型的临床前评估

Le Bihan, Amélie; de Kanter, Ruben; Angulo-Barturen, Iñigo; Binkert, Christoph; Boss, Christoph; Brun, Reto; Brunner, Ralf; Buchmann, Stephan; Burrows, Jeremy; Dechering, Koen J; Delves, Michael; Ewerling, Sonja; Ferrer, Santiago; Fischli, Christoph; Gamo-Benito, Francisco Javier; Gnädig, Nina F; Heidmann, Bibia; Jiménez-Díaz, María Belén; Leroy, Didier; Martínez, Maria Santos; Meyer, Solange; Moehrle, Joerg J; Ng, Caroline L; Noviyanti, Rintis; Ruecker, Andrea; Sanz, Laura María; Sauerwein, Robert W; Scheurer, Christian; Schleiferboeck, Sarah; Sinden, Robert; Snyder, Christopher; Straimer, Judith; Wirjanata, Grennady; Marfurt, Jutta; Price, Ric N; Weller, Thomas; Fischli, Walter; Fidock, David A; Clozel, Martine; Wittlin, Sergio

Identification and deconvolution of cross-resistance signals from antimalarial compounds using multidrug-resistant Plasmodium falciparum strains

利用多重耐药恶性疟原虫株鉴定和解卷积抗疟化合物的交叉耐药信号

Chugh, Monika; Scheurer, Christian; Sax, Sibylle; Bilsland, Elizabeth; van Schalkwyk, Donelly A; Wicht, Kathryn J; Hofmann, Natalie; Sharma, Anil; Bashyam, Sridevi; Singh, Shivendra; Oliver, Stephen G; Egan, Timothy J; Malhotra, Pawan; Sutherland, Colin J; Beck, Hans-Peter; Wittlin, Sergio; Spangenberg, Thomas; Ding, Xavier C