日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

A Long Residence Time Enoyl-Reductase Inhibitor Explores an Extended Binding Region with Isoenzyme-Dependent Tautomer Adaptation and Differential Substrate-Binding Loop Closure

一种长停留时间烯酰还原酶抑制剂探索了具有同工酶依赖性互变异构体适应性和差异性底物结合环闭合的扩展结合区域

期刊:ACS Infectious Diseases
影响因子:3.8
doi:10.1021/acsinfecdis.0c00437
Eltschkner, Sandra; Kehrein, Josef; Le, Thien Anh; Davoodi, Shabnam; Merget, Benjamin; Basak, Sneha; Weinrich, Jonas D; Schiebel, Johannes; Tonge, Peter J; Engels, Bernd; Sotriffer, Christoph; Kisker, Caroline
发表日期：2021
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Structures of endothiapepsin-fragment complexes from crystallographic fragment screening using a novel, diverse and affordable 96-compound fragment library

利用新型、多样化且经济实惠的96种化合物片段库，通过晶体学片段筛选获得内皮硫肽酶-片段复合物的结构

期刊:Acta Crystallographica Section F-Structural Biology Communications
影响因子:1.1
doi:10.1107/S2053230X16004623
Huschmann, Franziska U; Linnik, Janina; Sparta, Karine; Ühlein, Monika; Wang, Xiaojie; Metz, Alexander; Schiebel, Johannes; Heine, Andreas; Klebe, Gerhard; Weiss, Manfred S; Mueller, Uwe
发表日期：2016
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Rational design of broad spectrum antibacterial activity based on a clinically relevant enoyl-acyl carrier protein (ACP) reductase inhibitor.

基于临床相关的烯酰-酰基载体蛋白（ACP）还原酶抑制剂的广谱抗菌活性的合理设计

期刊:Journal of Biological Chemistry
影响因子:3.9
doi:10.1074/jbc.M113.532804
Schiebel Johannes, Chang Andrew, Shah Sonam, Lu Yang, Liu Li, Pan Pan, Hirschbeck Maria W, Tareilus Mona, Eltschkner Sandra, Yu Weixuan, Cummings Jason E, Knudson Susan E, Bommineni Gopal R, Walker Stephen G, Slayden Richard A, Sotriffer Christoph A, Tonge Peter J, Kisker Caroline
免疫/内分泌
发表日期：2014
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Structural basis for the recognition of mycolic acid precursors by KasA, a condensing enzyme and drug target from Mycobacterium tuberculosis

结核分枝杆菌缩合酶和药物靶点 KasA 识别分枝菌酸前体的结构基础

期刊:Journal of Biological Chemistry
影响因子:3.9
doi:10.1074/jbc.M113.511436
Schiebel, Johannes; Kapilashrami, Kanishk; Fekete, Agnes; Bommineni, Gopal R; Schaefer, Christin M; Mueller, Martin J; Tonge, Peter J; Kisker, Caroline
发表日期：2013
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Rational optimization of drug-target residence time: insights from inhibitor binding to the Staphylococcus aureus FabI enzyme-product complex.

合理优化药物靶点停留时间：从抑制剂与金黄色葡萄球菌 FabI 酶-产物复合物的结合中获得的启示

期刊:Biochemistry
影响因子:3
doi:10.1021/bi400413c
Chang Andrew, Schiebel Johannes, Yu Weixuan, Bommineni Gopal R, Pan Pan, Baxter Michael V, Khanna Avinash, Sotriffer Christoph A, Kisker Caroline, Tonge Peter J
微生物学
发表日期：2013
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