日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Genetic evidence for PARP1 trapping as a driver of PARP inhibitor efficacy in BRCA mutant cancer cells.

遗传证据表明,PARP1 捕获是 BRCA 突变癌细胞中 PARP 抑制剂疗效的驱动因素。

Ribeiro Jonathan, Hansen Kjetil, van Beek Lotte, Stubbs Christopher, Frigola Joan, Talbot Sara, Bentouati Sabrina, Hall James, Wijnhoven Paul W G, Armenia Josh, Schimpl Marianne, Forment Josep V, Albertella Mark R, O'Connor Mark J, Illuzzi Giuditta

Synthetic chemistry enabling the discovery and development of a series of pyrazoles as HPK1 inhibitors

合成化学促进了一系列吡唑类化合物作为HPK1抑制剂的发现和开发

Metrano, Anthony J; Morrill, Lucas A; Bommakanti, Gayathri; Casella, Robert; Cook, Steve; Escobar, Randolph A; Giblin, Kathryn A; Gosselin, Eric; Grebe, Tyler; Hariparsad, Niresh; Howells, Rachel; Lamont, Gillian M; Mele, Deanna A; Pflug, Alexander; Proia, Theresa A; Rezaei, Hadi; Richter, Magdalena; Richards, Ryan; San Martin, Maryann; Schimpl, Marianne; Schuller, Alwin G; Sha, Li; Sheppeck, James E 2nd; Song, Kun; Tang, Haoran; Wagner, David J; Wang, Jianyan; Wu, Allan; Wu, Dedong; Wu, Ye; Xu, Kevin; Ye, Minwei; Shields, Jason D; Grimster, Neil P

Combining structural and coevolution information to unveil allosteric sites

结合结构和共进化信息揭示变构位点

La Sala, Giuseppina; Pfleger, Christopher; Käck, Helena; Wissler, Lisa; Nevin, Philip; Böhm, Kerstin; Janet, Jon Paul; Schimpl, Marianne; Stubbs, Christopher J; De Vivo, Marco; Tyrchan, Christian; Hogner, Anders; Gohlke, Holger; Frolov, Andrey I

Discovery of a Novel Benzodiazepine Series of Cbl-b Inhibitors for the Enhancement of Antitumor Immunity

发现新型苯二氮卓类Cbl-b抑制剂可增强抗肿瘤免疫力

Boerth, Jeffrey A; Chinn, Alex J; Schimpl, Marianne; Bommakanti, Gayathri; Chan, Christina; Code, Erin L; Giblin, Kathryn A; Gohlke, Andrea; Hansel, Catherine S; Jin, Meizhong; Kavanagh, Stefan L; Lamb, Michelle L; Lane, Jordan S; Larner, Carrie J B; Mfuh, Adelphe M; Moore, Rachel K; Puri, Taranee; Quinn, Taylor R; Ye, Minwei; Robbins, Kevin J; Gancedo-Rodrigo, Miguel; Tang, Haoran; Walsh, Jarrod; Ware, Jamie; Wrigley, Gail L; Reddy, Iswarya Karapa; Zhang, Yun; Grimster, Neil P

Dynamics of the HD regulatory subdomain of PARP-1; substrate access and allostery in PARP activation and inhibition

PARP-1 的 HD 调节子域的动力学;PARP 激活和抑制中的底物进入和变构

Tom E H Ogden, Ji-Chun Yang, Marianne Schimpl, Laura E Easton, Elizabeth Underwood, Philip B Rawlins, Michael M McCauley, Marie-France Langelier, John M Pascal, Kevin J Embrey, David Neuhaus

Fragment-Based Design of a Potent MAT2a Inhibitor and in Vivo Evaluation in an MTAP Null Xenograft Model

基于片段的有效 MAT2a 抑制剂设计以及在 MTAP 无效异种移植模型中的体内评估

Claudia De Fusco, Marianne Schimpl, Ulf Börjesson, Tony Cheung, Iain Collie, Laura Evans, Priyanka Narasimhan, Christopher Stubbs, Mercedes Vazquez-Chantada, David J Wagner, Michael Grondine, Matthew G Sanders, Sharon Tentarelli, Elizabeth Underwood, Argyrides Argyrou, James M Smith, James T Lynch, 

PARP Power: A Structural Perspective on PARP1, PARP2, and PARP3 in DNA Damage Repair and Nucleosome Remodelling

PARP 的作用:从结构角度探讨 PARP1、PARP2 和 PARP3 在 DNA 损伤修复和核小体重塑中的作用

van Beek, Lotte; McClay, Éilís; Patel, Saleha; Schimpl, Marianne; Spagnolo, Laura; Maia de Oliveira, Taiana

Fertilization and seasonality influence on the photochemical performance of tree legumes in forest plantation for area recovery in the Amazon

施肥和季节性对亚马逊地区森林人工林中豆科树木光化学性能的影响

Jaquetti, Roberto Kirmayr; Gonçalves, José Francisco de Carvalho; Nascimento, Henrique Eduardo Mendonça; da Costa, Karen Cristina Pires; Maia, Jair Max Furtunato; Schimpl, Flávia Camila

Mapping the binding sites of antibodies utilized in programmed cell death ligand-1 predictive immunohistochemical assays for use with immuno-oncology therapies

绘制程序性细胞死亡配体-1 预测免疫组织化学检测中所用抗体的结合位点,以用于免疫肿瘤疗法

Nicola L Lawson, Carly I Dix, Paul W Scorer, Christopher J Stubbs, Edmond Wong, Liam Hutchinson, Eileen J McCall, Marianne Schimpl, Emma DeVries, Jill Walker, Gareth H Williams, James Hunt, Craig Barker

Correction: Mapping the binding sites of antibodies utilized in programmed cell death ligand-1 predictive immunohistochemical assays for use with immuno-oncology therapies

更正:绘制用于免疫肿瘤疗法的程序性细胞死亡配体-1预测性免疫组织化学检测中所用抗体的结合位点

Lawson, Nicola L; Dix, Carly I; Scorer, Paul W; Stubbs, Christopher J; Wong, Edmond; Hutchinson, Liam; McCall, Eileen J; Schimpl, Marianne; DeVries, Emma; Walker, Jill; Williams, Gareth H; Hunt, James; Barker, Craig