日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Discovery of EGT710, an Oral Nonpeptidomimetic Reversible Covalent SARS-CoV-2 Main Protease Inhibitor

发现 EGT710,一种口服非肽模拟可逆共价 SARS-CoV-2 主蛋白酶抑制剂

Papillon, Julien P N; Yuan, Jun; Hesse, Matthew J; Zhang, Lei; Robinson, Richard I; Ware, Nathaniel F; Hornak, Viktor; Karki, Rajeshri G; Kirrane, Tom; Garland, Keira; Joseph, Sajan; Moquin, Stephanie A; Lakshminarayana, Suresh B; Tandeske, Laura; Dovala, Dustin; Knapp, Mark; Ornelas, Elizabeth; Fuller, Daniel; Ho, Pei-I; Xie, Xuping; Vulic, Katarina; Skolnik, Suzanne M; Gao, Jinhai; Zambrowski, Mark; Spiess, Meike; Duca, José S; Busby, Scott A; Schirle, Markus; Robinson, Michael; Shi, Pei-Yong; Moser, Heinz E; Sarko, Christopher; Bradner, James E; Diagana, Thierry T; Tallarico, John A

Light-Activated Reactivity of Nitrones with Amino Acids and Proteins

硝酮与氨基酸和蛋白质的光激活反应

Skakuj, Kacper; Iglhaut, Maximilian; Shao, Qian; Garcia, Francisco J; Huang, Bo-Yang; Brittain, Scott M; Nesvizhskii, Alexey I; Schirle, Markus; Nomura, Daniel K; Toste, F Dean

Targeted Transcriptional Repression by Induced Proximity

诱导邻近效应介导的靶向转录抑制

Stieger, Christian E; Chen, Xinru; Dovala, Dustin; Wu, Fabian; Pizzato, Nicolas; McKenna, Jeffrey; Johannessen, Cory; Fodor, Barna D; Schirle, Markus; Nomura, Daniel K

Sulfinyl Aziridines as Stereoselective Covalent Destabilizing Degraders of the Oncogenic Transcription Factor MYC.

亚磺酰基氮丙啶作为致癌转录因子MYC的立体选择性共价去稳定化降解剂

Rosen Hannah T, Li Kelvin, Li Erin L, Currier Brynne, Brittain Scott M, Garcia Francisco J, Beard Diana C, Haenni-Holzinger Sandra, Dovala Dustin, McKenna Jeffrey M, Schirle Markus, Maimone Thomas J, Nomura Daniel K

Author Correction: DCAF1-based PROTACs with activity against clinically validated targets overcoming intrinsic- and acquired-degrader resistance

作者更正:基于 DCAF1 的 PROTAC 具有针对临床验证靶点的活性,可克服内在和获得性降解剂耐药性。

Schröder, Martin; Renatus, Martin; Liang, Xiaoyou; Meili, Fabian; Zoller, Thomas; Ferrand, Sandrine; Gauter, Francois; Li, Xiaoyan; Sigoillot, Frederic; Gleim, Scott; Stachyra, Therese-Marie; Thomas, Jason R; Begue, Damien; Khoshouei, Maryam; Lefeuvre, Peggy; Andraos-Rey, Rita; Chung, BoYee; Ma, Renate; Pinch, Benika; Hofmann, Andreas; Schirle, Markus; Schmiedeberg, Niko; Imbach, Patricia; Gorses, Delphine; Calkins, Keith; Bauer-Probst, Beatrice; Maschlej, Magdalena; Niederst, Matt; Maher, Rob; Henault, Martin; Alford, John; Ahrne, Erik; Tordella, Luca; Hollingworth, Greg; Thomä, Nicolas H; Vulpetti, Anna; Radimerski, Thomas; Holzer, Philipp; Carbonneau, Seth; Thoma, Claudio R

Rational Chemical Design of Molecular Glue Degraders

分子胶降解剂的合理化学设计

Toriki, Ethan S; Papatzimas, James W; Nishikawa, Kaila; Dovala, Dustin; Frank, Andreas O; Hesse, Matthew J; Dankova, Daniela; Song, Jae-Geun; Bruce-Smythe, Megan; Struble, Heidi; Garcia, Francisco J; Brittain, Scott M; Kile, Andrew C; McGregor, Lynn M; McKenna, Jeffrey M; Tallarico, John A; Schirle, Markus; Nomura, Daniel K

Correction to "Rational Chemical Design of Molecular Glue Degraders"

对“分子胶降解剂的合理化学设计”的更正

Toriki, Ethan S; Papatzimas, James W; Nishikawa, Kaila; Dovala, Dustin; Frank, Andreas O; Hesse, Matthew J; Dankova, Daniela; Song, Jae-Geun; Bruce-Smythe, Megan; Struble, Heidi; Garcia, Francisco J; Brittain, Scott M; Kile, Andrew C; McGregor, Lynn M; McKenna, Jeffrey M; Tallarico, John A; Schirle, Markus; Nomura, Daniel K

Donor-Acceptor Pyridinium Salts for Photo-Induced Electron-Transfer-Driven Modification of Tryptophan in Peptides, Proteins, and Proteomes Using Visible Light

利用可见光,通过供体-受体吡啶盐进行光诱导电子转移驱动的肽、蛋白质和蛋白质组中色氨酸的修饰

Hoopes, Caleb R; Garcia, Francisco J; Sarkar, Akash M; Kuehl, Nicholas J; Barkan, David T; Collins, Nicole L; Meister, Glenna E; Bramhall, Taylor R; Hsu, Chien-Hsiang; Jones, Michael D; Schirle, Markus; Taylor, Michael T

Photo-Brook rearrangement of acyl silanes as a strategy for photoaffinity probe design

光-布鲁克重排酰基硅烷作为光亲和探针设计策略

Page, Annika C S; Scholz, Spencer O; Keenan, Katherine N; Spradlin, Jessica N; Belcher, Bridget P; Brittain, Scott M; Tallarico, John A; McKenna, Jeffrey M; Schirle, Markus; Nomura, Daniel K; Toste, F Dean

An Activity-Based Probe Targeting Non-Catalytic, Highly Conserved Amino Acid Residues within Bromodomains

一种靶向溴结构域内非催化性、高度保守氨基酸残基的活性探针

D'Ascenzio, Melissa; Pugh, Kathryn M; Konietzny, Rebecca; Berridge, Georgina; Tallant, Cynthia; Hashem, Shaima; Monteiro, Octovia; Thomas, Jason R; Schirle, Markus; Knapp, Stefan; Marsden, Brian; Fedorov, Oleg; Bountra, Chas; Kessler, Benedikt M; Brennan, Paul E